Artificial Intelligence-assisted Endoscopic Diagnosis of Upper Gastrointestinal Precancerous...

Upper gastrointestinal precancerous lesions are important targets for cancer screening and prevention. This study evaluated the diagnostic accuracy of artificial intelligence (AI)-assisted endoscopy...

Metabolically Enhanced pH-Dependent Conformational Switching of Polymers for Selective Chemotherapy...

The selectivity of chemotherapy remains limited by systemic toxicity. pH-sensitive polymeric nanocarriers exploit the acidic extracellular environment of solid tumors as a drug-release trigger, but...

LDL Desialylation as a Trigger of Atherogenesis: Sialidase Inhibition as a Novel Anti-atheroscler...

Integrated Single-cell and Bulk Transcriptome Analysis Characterizes a Candidate Ccl4/Lgals3/Egr1...

Traumatic brain injury (TBI) induces neuroimmune activation and metabolic reprogramming in microglia, but the transcriptional regulators underlying these responses remain unclear. This study aimed to...

Biliary Duct Invasion in Colorectal Liver Metastases: Prevalence and Clinicopathologic Correlation...

Biliary duct invasion (BDI) is an underrecognized growth pattern of colorectal cancer (CRC) liver metastases that can mimic intrahepatic cholangiocarcinoma or intraductal papillary neoplasm of the...

Reporting Completeness of Biliary Atresia Organoid Studies: A Scoping Review and Structured Audit

Biliary atresia (BA) is the leading cause of pediatric obstructive cholestasis and a major indication for liver transplantation in infants. Organoid models are increasingly used to investigate BA...

Standardization Matters: Optimizing Ultrasound Attenuation Imaging for Reliable Quantification of...

Explainable Ensemble Machine Learning Framework for Lung Cancer Status Classification: A Retrospe...

Machine-learning approaches that combine predictive performance with model interpretability may improve lung cancer status classification. This study aimed to develop and internally evaluate an...

The Role of Macrophages in Atherosclerosis Development

Atherosclerosis is a chronic inflammatory vascular disease in which macrophages play central roles in lipid uptake, foam cell formation, plaque progression, plaque instability and, under certain...

Bridging Consensus and Precision: Interpreting the Chinese Pediatric Low-grade Glioma Guidelines

Sex and Self-reported Race: Factors Associated with Anal Mucosal Melanoma and Anal Mucosal Pigmen...

Anal canal melanoma (ACM) is a rare, aggressive malignancy with an ominous prognosis. However, its associated factors are largely unknown. Therefore, we investigated potential independent associati...

High Frequency of Circulating IL-4R+SELL+ Naïve B Cells Is Associated with Functional Cure in...

Although hepatitis B surface antigen (HBsAg)-specific B cells have been partially characterized in chronic hepatitis B (CHB), the role of naïve B cells and their potential relevance to functional...

Artificial Intelligence-driven Phenomics in Celiac Disease: Toward Precision Diagnosis

Celiac disease remains underdiagnosed despite an established diagnostic pathway, reflecting phenotypic heterogeneity, delayed recognition, and dependence on resource-intensive testing. This narrative...

The Role of Liquid Biopsy in the Detection, Risk Stratification, and Surveillance of Non-muscle-i...

Non-muscle-invasive bladder cancer (NMIBC) is characterized by a high recurrence rate and a substantial long-term surveillance burden. However, current detection and surveillance strategies rely...

Functional Interpretation of Differential Gene Expression in Cancer: From Lists to Mechanisms

High-throughput transcriptomic technologies have made differential gene expression analysis a cornerstone of cancer research by generating extensive lists of differentially expressed genes across...

Development of a Dysphagia Nursing Quality Evaluation Index System for Neurosurgical Inpatients...

Post-stroke dysphagia management research has primarily focused on screening, assessment, and intervention strategies, with limited objective indicators for evaluating nursing care quality. This...

Eosinophilic Esophagitis with Concurrent Gastric Helicobacter pylori Infection: An Underappreciated...

Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and ≥15 eosinophils/high-power field on biopsy. The specific clinicopathologic characteristics and therapeutic outcomes of...

Palmatine Induces TNNT1 Ubiquitination and Degradation to Potentiate Ferroptosis Sensitivity in...

Ferroptosis, an iron-dependent form of regulated cell death, serves as an important mechanism associated with cancer progression. Natural compounds, particularly alkaloids, have emerged as attractive...

On the Purpose of Artificial Intelligence in Critical Care Medicine

The modern intensive care unit (ICU) inundates clinicians with large volumes of data, leading to cognitive overload and a gap between data availability and actionable insight. While artificial...

Hepatitis Prevention and Control in Thailand: Current Challenges and Strategic Insights from...