@weixgroup

Weix Group at UW-Madison. Primarily student run, with the occasional DJW tweet. Mostly group news. @weixgroup.bsky.social

 Madison, WI
Joined November 2017
  • Tweets203
  • Following98
  • Followers4.7K
105Media
Perhaps belatedly, we are shutting down on twitter - thank you to all the chemists out there who participated. It was pretty awesome while it lasted! Times change and so must we. Check out our website for the latest news as we change up how we share things. -DJW
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Congratulations Dr. Lauren Ehehalt on a fantastic thesis defense! We're so excited to see all your future work at @EastmanChemCo 🥳🎉🎓
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Our work on the translation of Nickel-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling to Non-Amide Solvents is now online in @JOC_OL! Congrats to Brett, Julianna, Michelle, and wonderful collaborators at @NovartisScience. Check it out! doi.org/10.1021/acs.orglett.…

Translation of Nickel-Catalyzed C(sp2)–C(sp3) Cross-Electrophile Coupling to Non-Amide Solvents

Abstract. The cross-electrophile coupling of organobromides is widely utilized in organic synthesis but generally requires undesirable amide solvents (e.g.

pubs.acs.org
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Honoring Excellence in Chemistry Teaching! Congratulations to our 2025 Chemistry Teaching Award winners! Thank you for all of your hard work! Learn more here loom.ly/J00JlKM
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Congrats to Julianna for receiving an Outstanding Chemistry Teaching Assistant Award for your work with Chem 636 and the NMR facilities! Well deserved! 🎉
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Cross-Electrophile Coupling to Form Sterically Hindered C(sp2)–C(sp3) Bonds: Ni and Co Afford Complementary Reactivity | Journal of the American Chemical Society @UWMadison @UWMadisonChem @weixgroup @TotalSyntheses pubs.acs.org/doi/10.1021/jac…

Cross-Electrophile Coupling to Form Sterically Hindered C(sp2)–C(sp3) Bonds: Ni and Co Afford...

Abstract. The formation of sterically hindered C­(sp2)–C­(sp3) bonds could be a useful synthetic tool but has been understudied in cross-electrophile coupl

pubs.acs.org
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Our work on Ni- and Co-catalyzed Cross-Electrophile Coupling to Form Sterically Hindered C(sp2)–C(sp3) Bonds is now online at @J_A_C_S! Congrats to Tianrui, Anthony, Kasturi, and our collaborators Madeline (@KozlowskiMarisa) and @NovartisScience doi.org/10.1021/jacs.4c16912
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Our work on in-situ generation of alkyl chlorides using Ghosez’s reagent and coupling with aryl chlorides is now online at @JOC_OL Congrats Ben! Check it out! doi.org/10.1021/acs.orglett.…
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Ni-Cat Cross-Electrophile Coupling of ArOTf/AlkHal: Mechanism-Informed Design of General Conditions | Journal of the American Chemical Society @UWMadisonChem @UWMadison @TotalSyntheses -optimal ligand selection & LiCl avoids deleterious transmetalation pubs.acs.org/doi/10.1021/jac…

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Alkyl Halides: Mechanism-Info...

Abstract. Aryl triflates make up a class of aryl electrophiles that are available in a single step from the corresponding phenol. Despite the known reactiv

pubs.acs.org
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Our work on Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Alkyl Halides is now online at @J_A_C_S Congrats to Seoyoung, Matt, Ben, and Daniel! Check it out! doi.org/10.1021/jacs.4c14769

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Alkyl Halides: Mechanism-Info...

Abstract. Aryl triflates make up a class of aryl electrophiles that are available in a single step from the corresponding phenol. Despite the known reactiv

pubs.acs.org
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Welcome to Abi! We're excited to see all your awesome work in the group! 🥳✌️
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Wondering "What is XEC"? Want to use XEC but don't know where to start? Check out our guide to XEC, which includes a flowchart comprised of all the data we compiled during the writing of our Chemical Reviews publication! weixgroup.chem.wisc.edu/xec-…
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We're incredibly proud to say that our review of Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis is now online and open access at @ACSChemRev! Congrats to the team for this labor of love (and data!) pubs.acs.org/doi/10.1021/acs…
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Question 5: What Organic Additive is most commonly used across all XEC?
47%TMSCl
11%Pyridine
9%Trifluoroacetic Acid
33%nBu4Br
66 votes • Final results
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The wide variety of organic additives used means that TMSCl represents the largest portion with only 12% of all organic additives used. Silane reagents like TMSCl can activate metal powder reductants or by playing a direct role in the reaction mechanism.
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Question 4: What Cation is most commonly employed when Inorganic Additives are used in XEC?
32%Mg 2+
21%Li 1+
14%Na 1+
33%Zn 2+
81 votes • Final results
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While Zn salts can be generated in situ over the course of an XEC reaction, alkali and alkaline earth metal salts predominate by one to two orders of magnitude over other salt additives. Among all salt additives, Mg Salts (eg. MgCl2 and MgBr2) are the most common (27%)
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Decarboxylative Cross-Coupling Enabled by Fe & Ni Metallaphotoredox Catalysis | JACS @UWMadisonChem @EmoryUniversity @EmoryChem @TotalSyntheses #Minisci #Decarboxylative #CrossCoupling #FeNi #Metalaalphotoredoc #Catalysis pubs.acs.org/doi/10.1021/jac…

Decarboxylative Cross-Coupling Enabled by Fe and Ni Metallaphotoredox Catalysis

Abstract. Decarboxylative cross-coupling of carboxylic acids and aryl halides has become a key transformation in organic synthesis to form C­(sp2)–C­(sp3)

pubs.acs.org
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Question 3: What percent of XEC reports form Csp2-Csp3 Bonds?
16%40
36%55
24%63
24%85
25 votes • Final results
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While Csp2-Csp3 bonds do make up 55% of all XEC publications reported, the remaining 45% is comprised of a wide variety of other coupling types, from Csp2-Csp2 and Csp3-Csp3 to alkene and alkyne difunctionalization, among many others!
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