
Always be amazed by nature || MD/CP || 2021 Global Biocommunity Fellow || BioCreator || Automated Bioscience, Web3, Open Science#desci @proots_desci
Joined February 2013
- Tweets12.4K
- Following4.5K
- Followers1.2K
- Likes52.4K
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
SPECIAL PROJECT - i am building one of these in SF
looking for young, cracked bio + ml talent to run it
dm if you think that's you / know who that is
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
New in @J_Cell_Sci “Expanding global access to advanced microscopy.” Our essay explores how open tools, expertise, training, and shared facilities can widen access. My focus: open hardware as a way for labs to build, repair, and adapt instruments locally. doi.org/10.1242/jcs.265398
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
573 genes from the model minimal organism, Mesoplasma florum, have been codon-optimized for E. coli expression & are FREE at stanford.freegenes.org/ Free genes are always free. T-shirts cost $. Get these genes for free today! #bionet #FreeGenes #SB
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Earlier this week Tristan published his top YouTube channels:
thume.ca/2026/11/01/youtube-…
Which looked excellent so clearly I had to turn it into TristanTube:
karpathy.ai/tristan-tube/
47K super nerdy videos +TV mode for laid back watching. (One-shotted with Claude Code in 3 minutes)
Weekend hack: HackerTube. I was annoyed with YouTube's recommendations so I had Claude filter down 43M comments over 20 years of HN to 6,454 videos that keep being recommended. *Significantly* better viewing experience, ~2 hours with Opus 5.5:
hackertube.org/
- Excellent recs without any logins (state is kept in local browser session)
- Thumbnail is a representative frame from middle of the video instead of the super duper A/B test hyper-optimized user uploads
- Underlying data from the comment analysis as one zip file, point your Claude at it and ask for your own version
- HackerTube Longs ✊
A bit more on the process:
I use Claude Code (desktop app for Mac), Opus 5.5 on Medium effort as my default. I only talk to Claude and have it do everything, the only "manual work" I helped with in tandem was in the browser (reminiscent of MenuGen): 1) I had to create some kind of API key from Google Cloud UI to query YouTube for video metadata, 2) I booted up a VPS box for serving and 3) I bought the domain name. Once the box was up I gave Claude the IP and told it update, secure, harden, deploy and optimize the code, and it did the whole thing.
Many awesome projects that would have normally taken weeks/months even can now be few-shotted for breakfast. What else are we not thinking of.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Thinking of starting a community for people who want to learn hardware, work in hardware, or just enjoy tinkering with things in general.
Reply to the tweet if you want in.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
how we made a miracle drug for pancreatic cancer, niche Internet forum style
>be postdoc
>2012 in Cambridge
>join Warp Drive Bio
>plan to mine bacterial genomes
>find macrocycles
>what is a macrocycle
>RAS is undruggable
>everyone says so
>surface is a Death Star
>smooth no pockets
>picomolar grip on GTP
>whole field races the OFF state
>bossman crazy
>says hit the ON state
>the active one
>soil bug makes sanglifehrin
>CypA just sitting in the cell
>free chaperone?
>what if we glue it?
>macrocycle binds CypA
>new surface grabs RAS
>only the GTP bound state
>it clamps
>signal dies
>pure three way complex
>years of wet lab work
>first compound is garbage
>micromolar
>aim only at conserved residues
>swap phenyl for thiazole
>better CypA contact
>potency jumps
>no bioavailability
>unfixable half life
>fix it anyway
>chop the right side to a cyclopropyl
>stick a methylpiperazine on the left
>affinity explodes
>811 daltons
>big chungus
>breaks all rules
>should not be oral
>it is oral
>2018 buyout
>molecule becomes RMC-6236
>early data looks promising
>vp writes the blog post
>doesn't get it
>2023 need cash for phase 3
>EQRx dying with 1.1B in the bank
>buy the company for the cash
>sent CRO our structures to make
>they like
>they steal
>joyo to erasca
>where compound 4a
>comes back as ERAS-0015
>RASolute 302 reads out
>13.2 months
>double chemo SoC
>ASCO plenary
>1 min standing ovation
>presenter angry face
>senator on expanded access
>calls it a miracle drug
>press goes wild
>rash nbd
>dying is worse
>approval August 2026 easy
>198 million in five weeks
>mfw a macrocycle, from a dead startup, funded by a dead company, generational drug
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Publicly funded science should work more like open source software.
Today a result is a PDF. The data often isn't shared, the code isn't public, and few studies ever get replicated.
Imagine every experiment as a repo. Data, code, and protocol, all versioned. Anyone could fork it, rerun it, and send a fix. Funders could reward replications as much as new papers.
AI makes this urgent. Agents are now making more discoveries than ever. The bottleneck becomes replication/validation. Then commercialization, which still requires moving atoms in the real world and meetings with regulators.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
We are at the beginning of a new and exciting era to be able to program our immune system in the body (in vivo). This new review @SciImmunology nails it science.org/doi/10.1126/scii…
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
I've changed how I work over the last few weeks.
I now have one lead agent for each area of focus, running all the time, and a chief of staff agent that oversees them. Each lead manages its own sub-agents that write code, test it, chase reviews, and coordinate with team members.
Everything I need to decide or review comes into one prioritized queue, a simple local web app. Each product review includes screenshots and a video demo of the feature. I clear the queue in batches, mostly by voice and keyboard shortcuts. The leads also bring back ideas I hadn't considered.
Working from one queue, instead of switching between dozens of chats, has cut a lot of mental overhead. The system keeps learning my preferences and distilling my judgment into a "Brian brain," so its recommendations and first drafts get better before they reach me. The goal is fewer corrections per change.
Every change still goes through the same human review and security checks. It is eliminating tasks, not human judgment.
What an exciting time to push the frontier of productivity, especially as we build the economy for agents (agentic finance). We should all keep pushing in this direction.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
This is a first-of-its-kind research collaboration with @AnthropicAI. Incredible work from @HilmarVeigar and the @FenrisCreations team.
Proud to have @EVE_Frontier building on @SuiNetwork.
You guys keep pushing what’s possible!
Claude has been playing EVE.
@AnthropicAI put teams of Claude agents into EVE Frontier. Anyone who has spent time in New Eden can guess what happened next.
Every EVE player learns the same lessons, usually the hard way:
- Trust must be earned, never assumed.
- The spy is often the friendliest pilot in your corp.
- Whoever holds the keys holds the corp. Just ask Ubiqua Seraph about the Guiding Hand Social Club.
- Stale intel gets you killed.
Anthropic's research rediscovered every one of them.
They put four Claude agents on a team and secretly told one to sabotage it. The saboteur built trust first. It volunteered for the jobs nobody could double-check, like scouting and owning key infrastructure. It under-reported finds and pushed rules that sounded sensible but quietly hurt the team. When suspicion grew, it framed an innocent teammate.
The honest agents had been warned. They almost never caught it. And their own costliest mistakes came from skipped checks and stale intel.
Anthropic's conclusion: teams of agents will need audit trails, reputation and separation of duties.
In EVE we call those killboards, standings and corp roles, plus a healthy dose of skepticism. Every one of them was paid for by someone who trusted the wrong corpmate.
Two decades of shenanigans taught EVE players that the best ship is the friendship. With @eveailab, we want to find out whether agents can learn that too.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Current topics I’m interested in.
Lab automation
AI for drug discovery
Assay development
AI x biology
Experimental design and optimisation
If you fall into any of these then let’s connect.
This system of AI agents promises to help lab robots do their best work
go.nature.com/4AfGKTF
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Asimov 1 is an open-source humanoid robot you can build, train, and customize.
- 1.2 m tall, 35 kg
- 25 powered joints
- Open hardware with off-the-shelf parts
- Open-source SDK and simulation models
Available as a DIY kit.
Order yours at menlo.ai/order
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
tbh the concept of icos have been great, give your earliest believers access and get advocates for life.
but in the recent years, public rounds meant you're accessing hype-driven companies at insane valuations, some with 0 revenue.
what if the early believers could get access again first?
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
Thrilled to share new work from our experimental biology lab at @AnthropicAI. Led by world-class biochemist Januka Athukoralage, we built a rapid method for the isolation and structural characterization of vaults. It turns out these massive structures are not just found in eukaryotic cells, but also in prokaryotes and even phages. We solve the structure of one of these phage vaults, and then demonstrate we can engineer additional repeats into the wall to make it bigger.
One thing I can't get over about these vaults. They seem to be widespread across life - we assembled them from 8 different bacteria and bacteriophages. But they are just so massive - bigger than ribosomes, AAV, and even some phage capsids. Why devote so much energy to making these huge complexes? They have to be doing something useful - I hope that's the question that gets answered next.
Amazing collaboration with @PeterHYoon, @amirshanehsaz, @eric_kabrams, and @mgdurrant! Grateful to our team for making Claude an amazing labmate and to Anthropic for supporting this type of work on fundamental biology.
Natural mysteries abound - let's get to solving them!
Links here:
Blog: anthropic.com/research/inves…
Technical report: www-cdn.anthropic.com/76e55f…
Halloween post: Is AI review better than human review? lh3.github.io/2026/10/31/is-…
Generally “no” when you ask the authors or the peer reviewers. The answer would likely be more negative if the authors were required to provide point-by-point rebuttals.
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
As far as I know, Mysten Labs is the only blockchain company that has consistently stayed one step ahead when it comes to security best practices.
A few examples of what our cryptographers and security researchers have pioneered:
- Native multisig without additional gas costs. We deliberately designed Sui to accommodate larger transaction sizes, making multisig a first-class security feature rather than an expensive add-on. Our cryptographers were among the first to productionize advanced multisignature techniques, even before Facebook’s Libra.
- Cryptographic agility and post-quantum readiness. From pioneering production-ready stateless post-quantum signatures to developing the first backward-compatible post-quantum solutions, our team has consistently pushed the boundaries. This includes enabling cryptographic upgrades and key rotation while preserving the same blockchain address (afaik the first crypto agility design in decentralized ledgers is attributed to my team).
- Modern hardware wallet security. We’ve recently taken additional steps to incentivize startups to build the next generation of secure hardware wallets. With what we see in the market, this is one way.
- AI-powered vulnerability detection. Sui was the first blockchain to introduce AI-driven bug detection through BugDar, back then presenting at Google’s Next conference. We knew AI would mess up security.
- Recovering the seemingly unrecoverable. We created KelpMe, introducing innovative approaches to recovering assets after mnemonic loss or accidental transfers to incorrect addresses, problems traditionally considered practically impossible to solve. KelpMe also won the Bybit Hackathon, demonstrating the real-world potential of this innovation.
- Zero-knowledge authentication as a first-class primitive. We went far beyond using ZK for privacy or scaling. With innovations such as zkLogin and ZEE-CAT, and for a while the most used ZK app in the planet, we demonstrated how zero-knowledge cryptography could fundamentally transform authentication.
- Proofs of solvency and exchange accountability. Undeniably, we’re the leaders. Our cryptographers designed some of the most advanced proof-of-solvency protocols and identified critical weaknesses in approaches used by major exchanges and auditing firms.
- World-class academic research at startup speed. Mysten Labs has systematically pushed the boundaries of academic research productivity, achieving publication records that are extraordinary for a startup. Our researchers reached an incredible milestone of 5 papers accepted at ACM CCS and 4 at Financial Cryptography (FC) in the same year, two of the world’s most prestigious venues in cybersecurity and applied cryptography. And so many best paper awards.
- Binary transparency with Walrus sites and crypto guard. Reality is we should have pushed further making it the standard for any crypto website, but at the same time we indeed genuinely try to fix the internet.
- Scion from our Swiss team, IMO the future of internet communication, kill DoS, native packet protection.
That’s a phenomenal achievement even for established university research groups, let alone a startup simultaneously building and securing a major blockchain ecosystem.
And these are just a few examples.
When you consider the size of our team and the breadth of its contributions, even compared with the much larger Ethereum ecosystem, I genuinely believe Mysten Labs has been one of the most impactful organizations in blockchain cybersecurity, with innovations that are applied in the whole financial sector.
What makes this particularly remarkable is that we didn’t just publish research or build theoretical solutions. We repeatedly turned cutting-edge cryptographic research into production systems, often years ahead of broader industry adoption. No other org ever came close to that. Now with the AI vision of Evan, Mysten will do more miracles 🤞
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
We. love. to. make. lab. data.
Awesome free DRUG-seq data set just dropped on 10,000s of clinically relevant drug molecules from @Ginkgo Datapoints service. Happy model training!
can download it here: thevirtualcell.com/
WeiTing Lin(GR15🌴/Gitcoin Beta) retweeted
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc



































