professor UBC

Vancouver, British Columbia
Joined August 2018
Gastropathy associated with losartan with parietal cell loss mimics autoimmune gastritis but there is no enterochromaffin-like cell hyperplasia. There is only mild antral inflammation. This case has a collagenous gastritis pattern of injury. Note the pseudopyloric metaplasia.
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Years ago, colleagues noted that paraganglia (NOT paragangliomas) can mimic prostate adenocarcinoma on prostate needle biopsies. In the gallbladder, the issue would be a neuroendocrine tumor! pubmed.ncbi.nlm.nih.gov/1497…
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Not a GIPS member (yet!)? You're still invited. Join GIPS and @pathologyCast tomorrow for a free eMasterClass on WHO GI Tumors, 6th Edition – What's New? ✅ Open to everyone ✅ Free to attend ✅ No registration required #Pathology #GIPathology #MedEd
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Cholangioblastic cholangiocarcinomas are really interesting - I am old so I like the old name! Hissong E, et al. NIPBL::NACC1 Fusion Hepatic Carcinoma. Am J Surg Pathol. 2024 Feb 1;48(2):183-193. PMID: 38047392; PMCID: PMC11238093.
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The gang in Miami sees plenty HPV-associated anal glandular lesions - but you might be missing them- check it out! Mirzabeigi Y, et al. Expanding the Spectrum of High-Risk Human Papilloma Virus (HPV)-Associated Glandular Neoplasms of the Anorectum. Mod Pathol. PMID: 42392453.
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Horrible treatment (radiation) associated epithelial changes in duodenal mucosa. The p53 can be ignored, probably reflecting upregulation rather thana mutational event. The same can be seen in the stomach. Hutchings DA, et al PMID: 36843539; PMCID: PMC10460459.
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Dr. W Path retweeted
🔬 Case of the Week 🔬 Can you diagnosis this “polyp” in a middle aged man? Bonus: What additional testing (ex. IHC and/or Molecular) can you get to confirm the diagnosis?
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Distal rectal polyp - HPV-associated glandular neoplasms are rare and mimic tubulovillous adenomas. The mucin is peculiar and apical apoptotic bodies can be plentiful (arrow). Voltaggio L, et al. Mod Pathol. 2020 May;33(5):944-952. PMID: 31857682.
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This beautiful case was courtesy of Dr. Monica Garcia from #UMiamiPath @MonicaGarciaBu2
It's a minority of cases, but esophageal squamous cell carcinoma is sometimes HPV-associated, which conveys a better outcome. This example of high grade dysplasia is! Read about it in Modern Pathology! Reynders C, et al PMID: 40738325.
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My gracious! A sneaky presentation of metastatic mammary lobular carcinoma as a pancreatic mass.
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Here's a curious case. 15mm lesion intimately associated with the parathyroid. The cells are negative for S100, DOG1, PTH, Mammoglobin, NOR1/NR4A3 but positive for CK7. This is the third case I've seen in the last five years of consultation pathology in parathryoids. I've read literature on these and seen them called all sorts of things (mostly salivary gland carcinomas such as acinic or secretory, or benign salivary gland adenomas such as striated duct adenomas). But in my experience these are negative for the defining molecular features of those entities and I actually think this is a 'new entity'. I suspect that they are remnants of Kürsteiner canals (third pharyngeal pouch remnants seen in parathryoid glands). They are usually just simple cysts, but I think they can sometimes be mass-like. I think these account for the nests of PTH negative microfollicles you sometimes encounter in the thymus. This case is new, but the two previous cases have not recurred after simple excision. Has anyone seen similar cases? If so re-tweet with pics and maybe we can put together a series. If I am wrong and you think this is something else, please let me know
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Breast - Secondary Angiosarcoma vs Atypical Vascular Lesion (AVL) AVL are consistently negative for MYC amplification and negative for PRAME IHC (recently reported) Dr. Bean - 2025 Contemporary Issues in Breast Pathology #USCAP #pathology #PathX
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Dr. W Path retweeted
Elon Musk
@elonmusk1 Oct 2025
Cancel Netflix
Libs of TikTok
@libsoftiktok1 Oct 2025
HOLY SHIT. Show on @Netflix “The Baby-Sitters Club" pushes TRANSGENDERISM on KIDS, shames characters for "misgendering" and demands hospital staff refer to and treat a boy as a girl. INSANITY This show is rated for CHILDREN CANCEL NETFLIX
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Dr. W Path retweeted
What do you think about these deep glands in the gastric bx? There is a population of atypical glands admixed with benign glands. #gipathology
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#GIpath Sent to me as 60 y/o man with short segment of Barretts. No mention of tumor. Opinion ?
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Replying to @Vik_deshpandeMD
WT p53 can be seen in subset of HGD (20-30%, depending on what criteria you use for positive staining). Table 5 PMID: 36458877
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Barrett's esophagus. How would you interpret this p53 stain? #p53 #Barrettssesophagus
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A NUT carcinoma from the anterior neck of a young adult. A bit of squamous differentiation is indicated (arrow) but the low magnification appearance suggests a desmoplastic small round cell tumor. #UMiamiPath
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Glycogenic hepatopathy. The patient had poorly controlled type 1 diabetes, eponymously termed Mauriac's syndrome. The patients present with elevated transaminases and alkaline phosphatase as well. The swollen hepatocytes compress the portal tracts. #UmiamiPath
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Dr. W Path retweeted
Polypoid lesion of sigmoid colon. Not a frequently seen one 🙃 #PathTwitter #GIpath #BeautyInBenign
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