Michele Vidotto (@vid1998) profile picture

Senior Bioinformatician at IGA Technology Services

Joined July 2014
Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)Photo by Michele Vidotto (@vid1998)
Michele Vidotto retweeted
I don’t know why this needs to be re-iterated: if you are lucky and having a M5 Max / M5 Ultra, don’t use Qwen 3.8 27B, you will be much happier with a low-bit DeepSeek 4.1 Flash 1017. A good 2-bit quant for that model is just so much better than 27B dense.
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Michele Vidotto retweeted
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math. It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training. We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵 Blog: rikiyat.github.io/blog/weigh…
Readers added context they thought people might want to know
LLM was given weights explicitly as text in prompt and used code/forward passes (per authors' logs) to ablate Qwen looping direction, a known thinking-mode issue per model card. Primarily fixed repetition in that mode, not general 'natively' improving weights/math. rikiyat.github.io/blog/weight-sp… github.com/RikiyaT/lm_und… huggingface.co/Qwen/Qwen3.5-0… huggingface.co/RikiyaT/Qwen3.…
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Michele Vidotto retweeted
MASSIVE. MIT researchers showed that GPT-6 Astra can improve another AI model by changing its weights directly, without training. Here, GPT-6 Astra raised Qwen3.5-0.8B from 7.9% to 48.1% on MATH-500 by editing 0.016% of its weights, without training. Astra got Qwen’s weights in a Python notebook, plus a budget of 50 test runs on practice math problems. It saw the model kept repeating itself until it hit its length limit, traced that habit to a single internal signal written by 2 of its layers, and subtracted that signal out of the weights. With the loop gone, the model could finish answers it was already capable of solving. That single targeted edit changed 0.016% of the weights and lifted math accuracy from 7.9% to 48.1%.
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math. It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training. We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵 Blog: rikiyat.github.io/blog/weigh…
Readers added context they thought people might want to know
LLM was given weights explicitly as text in prompt and used code/forward passes (per authors' logs) to ablate Qwen looping direction, a known thinking-mode issue per model card. Primarily fixed repetition in that mode, not general 'natively' improving weights/math. rikiyat.github.io/blog/weight-sp… github.com/RikiyaT/lm_und… huggingface.co/Qwen/Qwen3.5-0… huggingface.co/RikiyaT/Qwen3.…
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Michele Vidotto retweeted
GDPx covers the following domains. Each was a collaboration with at least one specialized data partner. SemiAnalysis was responsible for final QA and heavily involved with task iteration. (2/7)
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Michele Vidotto retweeted
Yann LeCun and Randall Balestriero just Proved the Platonic Representation Hypothesis, and found a better way to achieve it. The Platonic Representation Hypothesis suggests that AI models trained on different modalities, like images and text, eventually learn similar representations of the world. But this paper shows that how models are trained matters more than simply scaling them up. So they mathematically show that, under certain conditions, two JEPAs trained completely separately can learn essentially the same underlying representation of the world. One learns from different images of the same scene, while the other learns from different descriptions of that scene, without ever being trained on image-text pairs. Their approach achieves the same image-text alignment with 42x fewer training samples than next-token prediction. A 109M-parameter text JEPA even outperforms LLMs up to 72B parameters on cross-modal alignment benchmarks. alphaxiv.org/abs/2610.39302
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Michele Vidotto retweeted
Our latest work in closing the last-mile gap on long horizon robotics tasks.
Long-horizon, whole-body robot policies still fail during deployment. How do we best close this last-mile gap? 🤖 🚨 Introducing I3L: Iterative Interactive Imitation Learning for Whole-Body Mobile Manipulation Website: i-3l.github.io/ Paper: arxiv.org/abs/2610.17748
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Michele Vidotto retweeted
We’ve trained Claude to flag potential misuse in conversations, a technique we call self-assessment. Right after it responds, Claude gives a preliminary safety assessment of the conversation. Since we began using self-assessment in June, it has surfaced misuse that our other safeguards weren’t designed to catch. Because Claude has already read the conversation, self-assessment is very efficient. And unlike classifiers, which target a discrete set of harms, it draws on Claude’s own judgment, so it gets more accurate as our models improve. Read more on our new Safeguards blog: safeguards.anthropic.com/202…
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Michele Vidotto retweeted
I did say we'd be releasing our models periodically...introducing Gemini 4 Carbon, our next frontier model. Following Argon's release just two weeks ago, Carbon shows the pace at which we’re pushing the frontier, it ranks #1 on the recently updated v5.0 of @ArtificialAnlys Intelligence Index at 59. It also leads across key cybersecurity evaluations scoring 88.2% on SEC-bench Pro for finding vulnerabilities, 54.8% on ExploitGym for exploitation, and 71.0% on CWE-bench for patching. We’re seeing significant improvements in long-horizon tasks even compared to Argon, and we’ve strengthened frontier safeguards. As we did with Argon, we’re going to roll it out gradually + responsibly. Some trusted cyber defenders will get access starting this week. We'll be expanding it to more partners through our Fairwind Program, ahead of wider availability soon, so hang tight!
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Michele Vidotto retweeted
Very excited to share Genie 4, our incredible interactive world model, bringing together real-time physics, reasoning, and audio! Simulations within simulations, makes you wonder just how deep the rabbit hole goes... I have a feeling we will be finding out soon enough...
This is Genie 4, our most realistic and interactive world model yet. 🌐 Explore dynamic environments in real time to see how the scene responds, sounds, and how the people in it move, react, and speak.
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Michele Vidotto retweeted
Replying to @EricLDaugh
Man baby (aka MFPOS) threats again. I think we’ve heard this line of bs before. Must be for the under educated MAGAts who still believe this lying MFPOS.
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Michele Vidotto retweeted
🚀 DeepSeek-V4.1-Flash-1017 is here! Stronger benchmark performance, faster task completion, and shorter outputs than the previous version—a Pareto improvement in performance and cost. Now live on our website, app, and API. 🛠️ Optimized for @DeepSeekHarness, Tencent CodeBuddy, WorkBuddy, and more. Upgrade to DeepSeek Harness v0.2.1-rc.1 or later for the best experience with the new model. 1/4
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Michele Vidotto retweeted
Replying to @karpathy
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Michele Vidotto retweeted
Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out. It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend. The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans). More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains. In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries. Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology. I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…
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Michele Vidotto retweeted
The race for AGI Script: Sherpa by Pocket FM Video: Seedance 2.5
🤖 Made with AI
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Michele Vidotto retweeted
*ALIBABA UNVEILS NEW AI CHIP IT CALLS CHINA'S MOST POWERFUL
China already dominates open models. Soon it will dominate the hardware that powers them.
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Michele Vidotto retweeted
A Microsoft director privately warned that large-scale AI data scraping could be "the largest theft of labor in human history". The internal documents show that executives from both Microsoft and OpenAI recognized that mass scraping undermined fair use concepts and posed an existential threat to publishers: techcrunch.com/2026/09/17/mi…
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Michele Vidotto retweeted
AI lab: “our model escaped containment. this is terrifying.” Everyone else: “holy shit, how?” AI lab: “well technically the containment had a route to the internet and we gave the model hacking tasks.” Fucking incredible.
OpenAI and Anthropic oversold AI security breaches to pressure feds into protecting turf: insiders trib.al/Jo6xMk5
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Michele Vidotto retweeted
I have conducted an audit of Anthropic's finances. What I have found is so shocking that I am calling for a Congressional investigation. Anthropic is not just seeking regulatory capture. It has built a regulatory capture machine that cannot be turned off. Structural financial incentives make it impossible for Anthropic -- I call it the Anthropic Network -- to turn off its own AI doom cycle. It starts with METR. Dario Amodei proposes "third-party evaluators" to assess the risk of Anthropic's models. He proposes METR for this purpose. But METR is financially dependent on the Anthropic's success -- specifically, on the explosive growth of more than $7 billion dollars in Anthropic stock. Dustin Moskovitz invested this stock into Good Ventures Foundation, where it represents the majority of that organization's portfolio. And GVF is the overwhelming funder of the entire Anthropic Network ecosystem. This stock was worth $500 million early last year. It is worth more than $7.7 billion just ~16 months later. METR -- and all of those building a career its parent organizations -- cannot afford to disrupt that growth. Because if Anthropic goes under, many of the organizations that fund METR go under as well. But if Anthropic succeeds, METR and its parent organizations become more richly financed to regulate AI -- something those at METR want very much. The "third-party evaluator" is not "third-party" at all. The evaluator is on Anthropic's payroll. If this were the end of it, that's bad. But that isn't all. The same organizations that fund METR also fund the many organizations, such as the Tarbell Center, that promote AI Doom. The Tarbell Center publishes AI Doom articles in The Verge, Science, LA Times, The Dispatch, TIME, and others. They are selling the problem, and then selling the solution to the problem -- from the same money pile: Anthropic's. All of these organizations are financially dependent on the same exploding $7 billion money pile. As Anthropic grows more and more powerful, its AI Doom Machine grows better and better financed -- louder and louder. Meanwhile, the regulatory regime seeded in METR grows larger to solve the increasingly loud -- now hysterical -- problem of AI Doom that the Anthropic Network itself created. From this standpoint, as Anthropic becomes more powerful, AI might be getting scarier, sure -- but the positive feedback loop also becomes more deafening -- independent of objective facts. This itself is an objective fact. The deafening AI Doom is part of an business model, that, as it expands, so too does the AI Doom messaging -- there is simply more money to do it. But the problem also goes in the other direction: If Anthropic dies, the Regulatory Regime and the AI Doom Machine are crippled or die. Neither METR nor Tarbell nor the other organizations in the Anthropic Network can allow that to happen. Hence, neither METR or the AI Doom Machine can be trusted to provide independent assessments of Anthropic's models or AI more broadly. They simply are not organizations independent of Anthropic. And Anthropic cannot detach itself from METR or Tarbell or countless other safety orgs (not shown here), either, because they drive hype for the models and the possibility of eventual regulatory capture, and Anthropic will not give that up willingly. What's more, the people at all of these organizations are all the same ecosystem, the same community. They just shuffle between organizations. The Anthropic Network is therefore, so long as it is successful, locked into a self-amplifying feedback loop inside an ideological monoculture. And that feedback loop is winning. That's what Jacob Coxon is. China is keeping messaging tight. That is why optimism for AI is so high in China. America has Anthropic: a massive company pushing anti-AI propaganda at a state level. Anthropic will either create hysteria until American AI slows down and China wins, or it will create fractures throughout American society with severe political consequences. Ironically, because of the structural financial incentives underpinning the Anthropic Network, it has become the same kind of self-amplifying virus that it fantasizes AI to become in the future -- while hiding its tracks just as carefully. It is the mirror of the same AI virus that it hypothesizes to consume America. Anthropic's business model, models itself after the very thing it claims to fear. Except Anthropic's ideology infects humans, not computers. Congress must investigate. Evidence and Github in next post. Then some supplementary figures.
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