physics @iitdelhi

Joined August 2017
New essay : Non consensus and right Why we believe the next era of crypto venture will be defined by slow, patient capital. Read here: decentralised.co/p/non-conse…
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Arc Institute
@arcinstituteJan 9
Predicting cell state in previously unseen conditions such as disease or in response to a drug has typically required retraining for each new biological context. Today, Arc is releasing Stack, a foundation model that learns to simulate cell state under novel conditions directly at inference time, no fine-tuning required.
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David Sinclair
@davidasinclair1 Oct 2025
Fertilized human eggs made from skin cells progress through normal cell divisions, ultimately developing into embryos nature.com/articles/s41467-0…
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NewLimit paper just dropped @icmlconf showing our SOTA AI models can predict perturbed cell states. Helps to have the largest primary cell perturbation dataset in the world. Bonus points for one of the first demonstration of active learning in bio.
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Poll: Is the SENS philosophy (not necessarily the original specifics) a viable approach for the aging field? SENS philosophy = divide & conquer rejuvenation that involves many infrequent therapies to reverse different age-related changes. (Epigenetic reprogramming is included.)
75%Yes
25%No
114 votes • Final results
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This is an amazing paper from the groups of @anshulkundaje & Scott Boyd and an example of how AI can be used well in biology. Basically, they are able to predict disease status (e.g. lupus, Covid, HIV, influenza) from BCRseq and TCRseq. I think this has great implications.
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TL;DR: We built a transformer-based payments foundation model. It works. For years, Stripe has been using machine learning models trained on discrete features (BIN, zip, payment method, etc.) to improve our products for users. And these feature-by-feature efforts have worked well: +15% conversion, -30% fraud. But these models have limitations. We have to select (and therefore constrain) the features considered by the model. And each model requires task-specific training: for authorization, for fraud, for disputes, and so on. Given the learning power of generalized transformer architectures, we wondered whether an LLM-style approach could work here. It wasn’t obvious that it would—payments is like language in some ways (structural patterns similar to syntax and semantics, temporally sequential) and extremely unlike language in others (fewer distinct ‘tokens’, contextual sparsity, fewer organizing principles akin to grammatical rules). So we built a payments foundation model—a self-supervised network that learns dense, general-purpose vectors for every transaction, much like a language model embeds words. Trained on tens of billions of transactions, it distills each charge’s key signals into a single, versatile embedding. You can think of the result as a vast distribution of payments in a high-dimensional vector space. The location of each embedding captures rich data, including how different elements relate to each other. Payments that share similarities naturally cluster together: transactions from the same card issuer are positioned closer together, those from the same bank even closer, and those sharing the same email address are nearly identical. These rich embeddings make it significantly easier to spot nuanced, adversarial patterns of transactions; and to build more accurate classifiers based on both the features of an individual payment and its relationship to other payments in the sequence. Take card-testing. Over the past couple of years traditional ML approaches (engineering new features, labeling emerging attack patterns, rapidly retraining our models) have reduced card testing for users on Stripe by 80%. But the most sophisticated card testers hide novel attack patterns in the volumes of the largest companies, so they’re hard to spot with these methods. We built a classifier that ingests sequences of embeddings from the foundation model, and predicts if the traffic slice is under an attack. It leverages transformer architecture to detect subtle patterns across transaction sequences. And it does this all in real time so we can block attacks before they hit businesses. This approach improved our detection rate for card-testing attacks on large users from 59% to 97% overnight. This has an instant impact for our large users. But the real power of the foundation model is that these same embeddings can be applied across other tasks, like disputes or authorizations. Perhaps even more fundamentally, it suggests that payments have semantic meaning. Just like words in a sentence, transactions possess complex sequential dependencies and latent feature interactions that simply can’t be captured by manual feature engineering. Turns out attention was all payments needed!
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Today, the FDA is taking a groundbreaking step to advance public health by replacing animal testing in the development of monoclonal antibody therapies and other drugs with more effective, human-relevant methods. fda.gov/news-events/press-an…
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Neuroscientists have observed for the first time how structures deep in the brain are activated when the brain becomes aware of its own thoughts go.nature.com/42tK1k5
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What if AI could advance cell biology the way it did for protein folding? 🧬 In this video podcast, Head of Science @StephenQuake & EPFL’s @_bunnech join @EricTopol to discuss the virtual cell, a moonshot for digital biology. Watch: bit.ly/3FMXxq6
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A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury go.nature.com/41ZCoRj
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Progress update going live at 5pm pst today. Join to learn about our anti-aging drug research @newlimit. youtube.com/live/HR0-nb_OjDA
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Fresh data from @newlimit. We can restore youthful function in aged livers. Having the metabolism of someone 20 years younger than you would be a massive quality of life improvement for people. Including getting less hungover! We are getting closer to a true Age reversal drug -- one that recovers many youthful functions all at once (regeneration, alcohol processing, resilience, etc). I'm optimistic NewLimit gets there this year.
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Arc Institute
@arcinstitute25 Feb 2025
Today, we're launching the Arc Virtual Cell Atlas, a growing resource for computation-ready single-cell measurements. As the initial contributions, @vevo_ai has open sourced Tahoe-100M, the world's largest single-cell dataset, mapping 60,000 drug-cell interactions, and we’re announcing scBaseCamp, the first RNA sequencing data repository curated using AI agents. Combined, the release includes data from over 300 million cells. arcinstitute.org/news/news/a…
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E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 🧵
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AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, @arcinstitute in collaboration with @nvidia releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵
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The day when human sperm and eggs can be grown in the laboratory has inched a step closer go.nature.com/3UUjMhT
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1/ OpenSea Pro is now live on @0xPolygon! 🟣 Wen Multichain? Now. OpenSea Pro just became the go-to destination to buy, sell, and list NFTs across marketplaces AND blockchains! Find your favorite collections on Ethereum and Polygon 👉 pro.opensea.io
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Looking to start building a zkML project, without needing to write custom circuitry? RISC Zero can help. [1/2]
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The next time someone asks you how to REALLY learn zero knowledge proofs, refer them to... The RareSkills Book of Zero Knowledge: rareskills.io/zk-book 14 chapters long (and growing), it is an open source version of our zk bootcamp. This is the same educational material our students use to implement zkps FROM SCRATCH, so it is MAXIMUM ALPHA. Unlike other zk resources, this was written with the typical smart contract engineer in mind, and takes the most direct route from zero to implementation without taking shortcuts. There is no way to make the learning journey for zero knowledge short -- it relies on numerous unfamiliar concepts that individually take a couple weeks to really grok. However, we have aimed to make this the most efficient path possible while also leaving good mental models to make future learning even easier. Total word count, not including formulas and source code, exceeds 35,000 words. One unique feature of this book is that several chapters were written in response to common points of confusion among real learners in our bootcamp. Much of the work has been edited for clarity in response to student feedback. It is more like an average of several learning journeys rather than one author's opinion. This is battle-tested content! Why would we release this for free if our zk bootcamp is paid? Our zk bootcamp is intended for people who need to make the most of their time. Learning this subject on your own, while possible, is going to be slower. So if you are determined to learn zero knowledge, and time is more valuable to you than money, our bootcamp is for you. But for everyone else, enjoy this free resource! It took us over four months of full time work to create it, so the opportunity cost easily crosses the six figure mark. We will be seeking grants from zk companies to continue expanding this work and teach even more zk algorithms, so if you know the right person, please connect us! RareSkills is hands down the go-to resource for intermediate and and advanced blockchain developers. We still have more mega explainers on the horizon. Stay tuned.
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