Pediatrician by profession, Explorer of rabbit holes by nature! (she/her) | Atheist | Feminist|

India
Joined June 2015
Dr Vanathi Sethupathi retweeted
This is one of the biggest geopolitical mysteries of the year: why did China just save the world economy? Because, make no mistake, it absolutely did. Analysts are pretty much unanimous on this: had China not dramatically - and I mean dramatically - reduced its oil imports this year, the price of crude oil would have gone through the roof and dragged the global economy down with it. For proof, read how Javier Blas from Bloomberg - widely recognized as one of the world’s top energy analysts - explains what China did to Jake Sullivan and Jon Finer on their podcast “The Long Game” (thelonggame.substack.com/p/t…). As Blas puts it, China went “from 11, 12 million barrels a day to less than 6 million barrels a day” of seaborne crude imports, and that “freed a lot of oil for other countries, particularly in Asia.” India, Japan, Korea and Southeast Asia “could buy the barrels that China was not buying.” To be clear, China wasn’t the only factor - surging US exports and the IEA’s emergency release helped too - but it was by far the biggest: JPMorgan reckons China accounted for about 74% of the fall in global crude trade (fortune.com/2026/06/10/oil-p…). So it's no exaggeration to say that it is China, first and foremost, that saved the world economy this year. If you remember the early days of the Iran war, none of this is what was predicted. In fact some US think tankers, such as the (always horrendous) Zineb Riboua from the Hudson Institute, were even cheering the war as being “all about China… the opening act in the larger contest against China,” the moment the US would crack “the central pillar of a regional order that Beijing has assembled” (thefp.com/p/the-iran-strike-…). Seven months on, what actually happened is that not only did China come out of the war unscathed economically, and strengthened strategically, it also ended up shielding the world economy, America’s included, from the fallout of the very war that was supposed to be its undoing. Breaking news: if you do something that’s supposed to be a “blow” to someone else - some sort of 3D chess move to gain the upper hand - and they end up having to rescue you from the fallout, maybe it wasn’t such a brilliant strategic move after all. So how did China pull it off? And, more intriguingly, why did it choose to rescue countries, including the US, from a war that Washington’s own hawks were openly selling as a strike against China itself? And why do this when it effectively dampened Iran's leverage considerably, even though they're supposed to be China's "ally" (which, as we'll see, is false)? This is the topic of my latest article. I went very deep researching all the Chinese sources I could find on this, looking at the exact legal mechanisms, and at what officials, oil refiners and state media actually said. The answer turns out to be far stranger than I expected: no-one in Beijing actually ever ordered an import cut. China, effectively, seems to have saved the world economy incidentally, as a by-product of its own domestic policy to protect Chinese consumers. Which is the real story here: China has become so large and so important it can just rescue the world economy as a mere side effect. In fact what I discovered, hilariously, is that the Chinese were just as surprised as anyone else: it’s only weeks after Western media started crediting China with saving the world economy that Chinese media picked up the story. And even then, CCTV’s first take in July (chinanews.com.cn/gj/2026/07-…) presented it as something 外媒称 (wàiméi chēng, “foreign media claim”) 🤣 Almost like a giant suddenly waking up to its own powers. Because, that's the thing: intentions fade, consequences stay. Intentional or not, as Igor Sechin, the head of Rosneft, Russia’s largest oil company, put it (reuters.com/business/aerospa…), the consequence is that it's now China, not OPEC, who calls the shots on global energy markets. The valve of global oil pricing is now in Shandong, not in Zhongdong anymore (Zhongdong, 中东, is the Middle East in Chinese). Full article here, with how China’s 20-year strategic nightmare, the “Malacca dilemma”, has now effectively become its leverage over the rest of the world: arnaudbertrand.substack.com/…
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"If we get good rainfall of about 5 cm every 15 days, we will be able to save the crops without depending on water from the Mettur Dam. If that doesn't happen, we will have to brace for a severe crisis,” said 'Cauvery' S Dhanapalan.
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Dr Vanathi Sethupathi retweeted
🧵 800-odd service postgraduates who completed MD/MS were given temporary postings without counselling or following seniority. Govt drs said this was a departure from the practice followed in the past few yrs, when vacancy lists were notified & counselling held for postings.
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Tamil Nadu may be staring at an acute water crisis in an El Niño year, with water storage at major reservoirs across the state dropping to a critical level of 35.36 per cent of their total aggregate capacity.
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Is there a delay going on with Greece Schengen visas from India? Asking for a friend who is due to travel in 2 weeks; been a full month since application. @outofofficedaku @TravelBluez any help?
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So does TN govt have any plans? Next year is looking very scary
Monsoon 2026 final results interpreted Legend: Yellow =. Severe Deficit Red = Deficit Green = Normal Light Blue = Excess Dark Blue = Super Excess
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Dr Vanathi Sethupathi retweeted
A coach who speaks 7 languages communicating by signs, a downpour that played spoilsport, a medal that didn't matter & a record that did. Here's how Vithya Ramraj smashed 🇮🇳 oldest track record - PT Usha’s 400m hurdles mark- at the Asian Games 2026. sportstar.thehindu.com/asian…
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Ballad of Homelanders! ☺️
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Fantastic! @sakie339 you should read this if you haven’t already!
University debate, "Were humans built to eat meat?", same two chairs, same clock. Vegan: "Anatomically we're closer to the gorilla than the lion. Flat molars, long gut. A gentle plant-eater with delusions." Paleoanthropologist: "Then explain the acid." Vegan: "Which acid?" Paleoanthropologist: "Your stomach runs at a pH of about 1.5. A lion's sits nearer 3.6. Yours is stronger than the animal you've just been contrasted with, by a factor of about a hundred." Vegan: "Stomach acid digests food." Paleoanthropologist: "A cow's rumen sits at about 6.5. That's a compost heap with a pulse. Yours strips the zinc off a coin. Why would a gentle plant-eater carry that?" Vegan: "Protection." Paleoanthropologist: "From what? Lettuce doesn't fight back." Vegan: "Bacteria." Paleoanthropologist: "Which bacteria live in a leaf at a level that needs a pH of 1.5? Name the salad." Vegan: "..." Paleoanthropologist: "The animals that run acid as low as ours are the scavengers. Vultures. Things that arrive at a carcass on the second day and need to kill what's already living in it. We're not built like the lion. We're built like the bird that waits for the lion to finish." Vegan: "Flattering." Paleoanthropologist: "It's a picture of a species with a rock, a sharp flake and no claws. You don't get the fresh kill. You get the femur nobody could open, forty hours late, and you'd better have the acid for it." Vegan: "Acid that strong is dangerous. Look how many people are on tablets for it." Paleoanthropologist: "The only animal on earth that pays to switch its stomach off. You've spent sixty years pouring cereal onto a carcass digester and now you're medicating the digester for doing its job." Vegan: "So your argument is that we're vultures." Paleoanthropologist: "My argument is a number. Yours is a feeling about gorillas. The gorilla eats for most of the day and its gut is a fermentation tank. Yours is done in a few hours and runs on acid. One of you is designed for leaves." Moderator: "Thirty seconds." Paleoanthropologist: "She can keep them. I'm still waiting on the salad."
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Dr Vanathi Sethupathi retweeted
I strongly encourage everyone to read the speech that Chan Chun Sing, Singapore's Defence Minister, just gave in Beijing: it's basically the polar opposite of a Hegseth speech - immensely wise and a refreshing proof that thoughtful statecraft still exists. You can find the speech here: mindef.gov.sg/news-and-event… Below a summary of the best parts of the speech, in my opinion. Much of the speech addresses the crucial question of the so-called "security dilemma", a key concept in international relations theory whereby one country's efforts to make itself safer almost inevitably make others feel less safe, triggering a spiral where everyone ends up more insecure. As Chan Chun Sing puts it in his speech: "The true test of statecraft is this: how do we strengthen our own security without weakening the security of others, or without aggravating the insecurity of others?" He says there are "three fundamental principles worth bearing in mind" in this regard, but that, first and foremost, it raises the question of "what 'winning' means": to him, defining "winning" as "outgunning or outlasting a rival" isn't sensible, it ought to be defined as winning others through the "power of our example", rather than "the example of our power." It's extremely wise, when you think about it: do you actually "win" if you submit others by force, or do you merely prove that, for now, they simply lack the strength to resist? You've imposed your will, yes, but the principle you've imposed is that the strongest gets his way, and strength is expensive and it wanes. Chan Chun Sing quotes Mencius, the classic Chinese philosopher, to illustrate this: "Power may compel others to comply. But in the end, it is trust that truly wins others over" (which is a trimmed version of the true original citation: "Those who subdue others by force do not win their hearts; they submit only because their own strength falls short. Those who subdue others by virtue win hearts that are glad and sincerely submissive, as the seventy disciples submitted to Confucius," 以力服人者,非心服也,力不赡也;以德服人者,中心悦而诚服也,如七十子之服孔子也。) This is very core to Chinese strategic thinking (yes, Chan Chun Sing, as are most Singaporean leaders, is ethnically Chinese): the notion that legitimacy, not force, is the real currency of power. A state that has to coerce is following the "hegemonic way" (badao, 霸道) - which is brittle and unsustainable. The only sustainable long-term way to lead is the so-called "kingly way" (wangdao, 王道), where others follow you and emulate you voluntarily. Two concepts which incidentally come from Mencius too: "he who uses force while borrowing the name of benevolence is a hegemon (ba); he who practises benevolence through virtue is a true king (wang)." Concretely, Chan Chun Sing say that states should pursue the following 3 principles to apply this in practice. First of all, he points out that too many states "externalise domestic issues" as opposed to putting their own house in order. The idea being that a leadership confident at home doesn't need foreign enemies to hold itself together, and can therefore act in its "enlightened long-term interest" abroad. Whereby an insecure one uses foreign policy "for political gain." No prizes for guessing what country he is referring to here... The second principle is that "interdependence breeds stability" as opposed to being "a source of vulnerability." Which makes sense: mutual exposure turns competitors into stakeholders in each other's stability. Cut exposure in the name of "resilience" or "de-risking" and, really, the only thing you've achieved is to make confrontation and conflict cheaper. Lastly, and this is perhaps the most important principle: "first, do no harm." Chan Chun Sing again quotes famous Chinese sayings: "turn big problems into small ones, and small ones into nothing" (大事化小,小事化了), which is what happens when there's trust between states, versus "turn small problems into big ones, and make trouble out of nothing" (小事化大,无事生非), which is what happens when there isn't. The idea is that every unnecessary provocation, every "freedom of navigation" stunt, every gratuitous sanction is a withdrawal from a trust account that is very expensive to fill and, as he says, can be emptied "in a single instant." Chan Chun Sing ends his speech on what being a “responsible major country” - a key concept in contemporary Chinese international relations - means, and how, "the more responsible major powers are, the less concerned small countries will be." Besides the above three fundamental principles, he says that "strategic patience" is also crucial, defined as: "Not every capability needs to be advertised; not every advantage needs to be immediately pressed; and not every provocation demands an immediate response." In other words, true confidence doesn't need to prove itself and restraint is a form of strength: a great power that feels compelled to respond to everything is, in effect, letting its rivals set its agenda. And whoever needs to constantly show force is in fact projecting its own fear that without the show, nobody would believe it. As Margaret Thatcher once brilliantly put it (I hate to quote her but this is too good): "Being powerful is like being a lady. If you have to tell people you are, you aren't." That's it, if you want the rest, I truly encourage you to read the full speech: pure undistilled wisdom, from a man who runs the defence of a country smaller than Los Angeles and obviously understands power far better than the man in charge of the largest military on earth. Which is its own form of tragedy.
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Dr Vanathi Sethupathi retweeted
You can say what you want about Iran but they're definitely pretty unique in their communication: never seen a country threaten another with a math equation before 😅 For those who didn't get it: there is a famous monetary policy formula used by the Fed called the "Taylor rule" that says a central bank's policy rate (i) should equal the neutral real rate (r*) plus target inflation (π*), plus 1.5 times the inflation gap and 0.5 times the output gap (the "i = r* + π* + 1.5(π−π*) + 0.5(y−y*)" part of Ghalibaf's formula). Ghalibaf adds α(SOH−SOH*) and β(BEM−BEM*): SOH referring to the Strait Of Hormuz and BEM to Bab El-Mandeb. Both have positive coefficient, meaning the more those chokepoints are choked, the higher the rate the Fed would have to set to fight the resulting inflation. In a nutshell this is Ghalibaf trolling the Fed, telling them that Iran is - in a very real way - setting American monetary policy.
Straits Taylor Rule: i = r* + π* + 1.5(π−π*) + 0.5(y−y*) + α(SOH−SOH*) + β(BEM−BEM*), α,β > 0 Let’s see if a hike could open SOH or produce a single barrel :) You can’t 25bp a chokepoint and r* isn’t neutral. It’s SOH risk premium, and We set it. Stay unanchored !
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பெரியாரைப் படிப்போம்; அவர் விதைத்த சிந்தனைகளை உலகெங்கும் விதைப்போம்; நாளைய உலகை பகுத்தறிவும் சமத்துவமும் நிறைந்த உலகாகப் படைப்போம்! #SocialJusticeDay #PeriyarForever
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Dr Vanathi Sethupathi retweeted
the whales do not give a fuck what you looked like in the 80’s and would rather you not destroy our planet so we have a chance to see what we might look like in the 30’s
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இன்று முதல் அவர் Vetri Putin !
CM விஜய்யும்... ரஷ்ய அதிபரும்! #CMVijay #Putin #ThanthiTV #தந்திடிவிடிஜிட்டல்
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Dr Vanathi Sethupathi retweeted
When CM Joseph Vijay announced that the Parandur airport will be scrapped, a lot of pro-TVK handles wrongly claimed “Vijay was taking on PM Modi by dropping an Adani project” when in reality, there was no connection between Parandur project & Adani. But here is an actual Adani project if someone wants to indulge in bravado. Adani Green Energy Limited has proposed setting up a 1,800-MW Alleri Pumped Storage Project, involving two reservoirs, dams, tunnels and an underground powerhouse in the hill, where 13 tribal villages are located.
The @TVKVijayHQ govt is on a spree to cancel projects announced by previous @arivalayam govt. People of Jawadhu hills hope against hope for this Adani project to go on the chopping block A dam plan & fear of doom: Jawadhu Hills tribal villages under the imposing shadow of Adani’s ambition. thesouthfirst.com/tamilnadu/…
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Dr Vanathi Sethupathi retweeted
முக்கிய அறிவிப்பு 🔈 அரசுப் பள்ளிகளில் படித்து 7.5 சதவீத அரசு ஒதுக்கீட்டில் தமிழகத்தில் உள்ள மருத்துவக் கல்லூரியில் மருத்துவம் பயில தேர்வாகி உள்ள மருத்துவ மாணவர்களுக்கு தமிழ் உறவுகள் வழிகாட்டி மருத்துவக் குழு கடந்த ஐந்து வருடங்களாக
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Dr Vanathi Sethupathi retweeted
Years ago at Vellore, Dr Paul Brand examined a young man affected by leprosy. When Brand simply touched him, the man broke down in tears. Why? Because after he developed leprosy, even his own family had stopped touching him. For years, fear and stigma had deprived him of something as basic as human contact. That was the social reality around leprosy, a disease surrounded by myths, fear, exclusion and superstition. And what did a progressive State do? In 1971, under Thalaivar Kalaignar, Tamil Nadu established rehabilitation homes for persons affected by leprosy not to legitimise fear, but to defeat it. The response was medical care, rehabilitation, vocational training, employment and social reintegration. When society feared touching a person with leprosy, the State did not build policy around that fear. It used science and social justice to dismantle it. That is what rational governance looks like. More than fifty years later, the TVK government now announces ₹1.5 crore for a "mandapam" for people affected by chickenpox. Kalaignar's Tamil Nadu confronted the stigma around disease with science, dignity and rehabilitation. Today's government appears determined to travel in the opposite direction. Governments have a very important obligation to separate faith from epidemiology and belief from evidence. A scientifically progressive state does not institutionalise beliefs as public health policy especially when it's about a very contagious infection. Tamil Nadu did not spend decades moving from superstition to science only for a government to spend ₹1.5 crore moving us backwards.
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Dr Vanathi Sethupathi retweeted
🧬 HOW DOES A PERSONALIZED mRNA CANCER VACCINE ACTUALLY WORK? As an oncologist, and also as a university professor, I strongly believe that understanding how a new treatment works is often the best way to understand why it may eventually change our clinical practice. So, what exactly is a personalized mRNA cancer vaccine? The concept is both sophisticated and surprisingly intuitive. 1️⃣ Start with the patient's own tumor 🧬 Every cancer is genetically different. By sequencing tumor DNA and RNA, and comparing this information with normal tissue , we can identify tumor-specific mutations. Some of these mutations generate abnormal proteins that are not present in healthy cells. These are called neoantigens. And importantly, they can become molecular "flags" allowing the immune system to distinguish cancer cells from normal cells. 2️⃣ Select the best targets 🎯 Not every mutation will generate an effective immune response. Bioinformatic algorithms therefore analyze the patient's tumor and predict which neoantigens are most likely to be recognized by their immune system. In the case of intismeran autogene, up to 34 patient-specific neoantigens can be selected. 3️⃣ Build an individualized mRNA therapy 💉 Here comes the fascinating part. A synthetic mRNA sequence encoding those selected neoantigens is manufactured specifically for that individual patient. Think about what this means. We are no longer simply choosing the best available drug for a patient. We are manufacturing a treatment based on the molecular identity of that patient's own cancer. 4️⃣ Teach the immune system what to recognize 🛡️ After administration, the mRNA enters cells and provides the instructions to produce the selected neoantigens. These neoantigens are processed and presented to the immune system, activating tumor-specific CD4+ and CD8+ T cells. The objective is to generate an immune response capable of recognizing cells carrying those same neoantigens. 5️⃣ Let T cells search for the cancer 🔎 Those activated T cells can then recognize tumor cells displaying the corresponding antigens and potentially destroy them. This is why combining personalized vaccination with PD-1 blockade such as pembrolizumab makes so much biological sense: 🎯 The vaccine may teach the immune system WHAT to attack. 🔓 Checkpoint inhibition may help the immune system KEEP attacking it. And this is where, in my view, the concept becomes much bigger than one drug or one tumor type. For many years, we have defined precision oncology as: “the right treatment for the right patient.” Personalized mRNA vaccines introduce an even more ambitious paradigm: “a treatment designed and manufactured specifically from the molecular characteristics of one patient's cancer.” @OncoAlert @_SEOM @moderna_tx @GEPAC_ Figure adapted from: doi:10.3390/cancers17091408.
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Dr Vanathi Sethupathi retweeted
Moderna/Merck just ran a 1,137-patient Phase 3 trial where every single dose was unique to that patient's tumor. It worked. The pipeline: surgical resection → whole exome + RNA sequencing → ML neoantigen ranking → mRNA encoding up to 34 patient-specific targets → manufactured and shipped in 8 weeks. One drug, different sequence for every patient. The ML step is worth to note: the algorithm ingests WES + RNA-seq to identify somatic mutations, then predicts which of those will actually be immunogenic, ie, displayed on tumor cell surface and trigger a T-cell response. It's designed to keep learning from accumulated clinical and immunogenicity data across patients, not just per-patient. INTerpath-001 (Stage IIB-IV resected melanoma, 2:1 randomized): combination with pembrolizumab beat Keytruda alone on both primary (RFS) and key secondary (DMFS) at interim. Phase 2b at ASCO 2026 showed 49% reduction in recurrence/death, 59% in distant metastasis/death at 5 years. Phase 3 confirmed both. What this validates: — tumor-specific neoantigen prediction by ML works in a blinded trial at scale — 8-week personalized mRNA manufacturing is operationally real — effect is additive on PD-1 blockade, not redundant This is first positive Ph3 for individualized neoantigen therapy. First positive Ph3 for any mRNA cancer therapeutic. What a great time to live in!! This is the best time for AI & biotech!
Moderna and @Merck today announced positive topline results from the Phase 3 INTerpath-001 trial evaluating adjuvant treatment with intismeran autogene, a novel investigational mRNA-based individualized neoantigen therapy jointly developed by Merck and Moderna, in combination with KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, in patients with completely resected Stage IIB-IV melanoma. Read more:
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Dr Vanathi Sethupathi retweeted
Everyone should take the Flu vaccine this year.
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