I keep seeing the same before-and-after with thiamine (b1). An elderly patient, deep in dementia, given high-dose B1, and a month later they are lucid again. It is not a miracle. It is the most predictable thing in the world once you understand what thiamine does in the brain. Your brain runs almost entirely on glucose, and glucose only becomes usable energy if it can pass through one cellular gate called PDH. Thiamine is the cofactor that opens that gate. Low thiamine severely impairs your fuel and energy. The most energy-hungry tissue you own is the first to take the hit. When researchers measured the brains of Alzheimer's patients directly, PDH activity was down 41% and the next enzyme in the chain was down 57%. The size of that drop tracked how severe the dementia was (Bubber 2005, Ann Neurol). The brain was STARVING at a gate that is dependent on thiamine. So why does the blood test say "normal"? I mean none of these people are 'deficient' on thiamine, right? No, blood is the wrong place to look. The body can be depleted of circulating thiamine while the standard blood tests still read normal. A normal result does not rule out a starving cell. So many unrelated conditions seem to get better when you make sure the body has sufficient thiamine, which is honestly pretty hard in the modern world. Many of my clients have improved so much energy-wise, I've seen many diabetics improve from it, I've seen incredible therapeutic effects in elderly patients.... I'm very bullish on thiamine.