@uknpsc

National Phenotypic Screening Centre: a leading collaborative initiative using physiological assays to probe disease & accelerate therapeutics discovery.

 Dundee | Oxford | Edinburgh
npsc.ac.uk
Joined May 2014
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  • Followers1.1K
273Media
Breaking News: Phenotypic Screening is now open for applications at the European Lead Factory. We are doing the complex high content and/or flow cytometry-based assays. This is a unique opp. to get high quality chemical hit matter from a unique library. europeanleadfactory.eu/node/…
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Today, members of the @EULeadFactory are meeting for the 2022 Annual Consortium Meeting. Special thanks to our partner @grunenthalgroup for hosting the event! A great opportunity to meet in person again, share progress updates & discuss the outlook for the coming year.
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Upcoming deadline for fully funded HCS screens for exciting targets via @EULeadFactory See europeanleadfactory.eu/drug-… Submit by Jan 21!!

Call for proposals | European Lead Factory

There are currently no calls open at the ELF

europeanleadfactory.eu
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Great news! The @uknpsc & @DDU_Dundee based in the School are working with Chris & his team on developing a male contraceptive. You can find out the most recent update on the project in their @eLife paper: buff.ly/33uUcVy
UoD Medicine@UoDMedicine19 Mar 2020
Professor Chris Barratt, a world-leading expert in male fertility, is to head an international task force to help tackle the global crisis in this area. Read more: buff.ly/2J0ZW02
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Professor Chris Barratt, a world-leading expert in male fertility, is to head an international task force to help tackle the global crisis in this area. Read more: buff.ly/2J0ZW02
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NPSC retweeted
NPSC@uknpsc14 Jan 2020
Breaking News: Phenotypic Screening is now open for applications at the European Lead Factory. We are doing the complex high content and/or flow cytometry-based assays. This is a unique opp. to get high quality chemical hit matter from a unique library. europeanleadfactory.eu/node/…
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<3 "All reviewers agreed that this manuscript reports an important advancement in the development of the tools aimed to provide an unbiased search for novel contraceptives….” Thanks @eLife
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There’s also a nice eLife Insight piece by Luke L McGoldrick and Jean-Ju Chung elifesciences.org/articles/5… #openscience #disruptivetechnology

Contraception: Stopping sperm in their tracks

An automated high-throughput platform can screen for molecules that change the motility of sperm cells and their ability to fertilize.

elifesciences.org
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Our @eLife paper is out properly now: A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity #malecontraception #malepill doi.org/10.7554/eLife.51739

A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive...

A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.

elifesciences.org
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Excellent topical documentary about #crispr & implications for society #Storyville #geneediting #crisprcas9 #genomeengineering The Gene Revolution: Changing Human Nature: bbc.co.uk/iplayer/episode/m0… via @bbciplayer

BBC Four - Storyville, The Gene Revolution: Changing Human Nature

The biggest tech revolution of the 21st century isn't digital, it's biological.

bbc.co.uk
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Nice to spend time thinking about art, science and visual thinking at the @LifeSpaceDundee @DJCAD @UoDLifeSciences future gazing workshop.
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Our Image and Science Writing competitions are both now open with entries due by 29th February 2020. Cash prizes! Details at bscb.org. Please enter!!
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Happy International Day of Women and Girls in Science! We're supporting #colleges and #universities to tackle gender imbalances in STEM subjects with our iGAP guidance bit.ly/2ShyVuI #WomenInScience
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Really interesting paper from ⁦@Novartis⁩ - 44 fluorescent chemical probes to interrogate cellular phenotypes in an unbiased way. Fluopack screening platform for unbiased cellular phenotype profiling | Scientific Reports nature.com/articles/s41598-0…
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Excellent job ⁦@eLife⁩ Science Forum: Ten common statistical mistakes to watch out for when writing or reviewing a manuscript | eLife elifesciences.org/articles/4…
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It was great to hear Ivan @iDikic2 talk about his research today. Very bold and innovative 👏🏽Fun to give him a tour of the lab afterwards too!
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Taking phenotyping deeper with network analytics and "reticulotypes"(patient's unique molecular network) in cardiovascular medicine jci.org/articles/view/129203 @jclinicalinvest by Jane Leopold @BrighamWomens and colleagues
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Here’s some natural marine beauty followers to offset some of the awful humans walking on this planet #wednesdaymood
Massimo
@Rainmaker19735 Feb 2020
Photographer Alexander Semenov captured this under-the-ice footage at the White Sea in March 2018: life is there, undisturbed, as confirmed by jellyfish and by this hovering sea angel [full video: buff.ly/3b7KFr3]
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Wow 👇🏽👇🏽👇🏽👏🏽👏🏽👏🏽👏🏽
Xavier Trepat@XavierTrepat4 Feb 2020
In case you’ve missed it, here’s a beautiful example of a closed mechanochemical feedback loop by Tsuyoshi Hirashima’s lab. Collective migration, waves, FRET sensors, #optogenetics... and some mechanical tools from our lab! biorxiv.org/content/10.1101/…
A recent article from @IMI_JU highlights the importance of Public-Private Partnerships in health. It discusses several important initiatives, including the #EuropeanLeadFactory, stressing the valuable role #PPPs play in furthering #drugdiscovery research: europeanleadfactory.eu/node/…
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#KCGS is live! Our #Kinase Chemogenomic Set is the most diverse and highly annotated publicly-available collection of kinase inhibitors that can be used for #drugdiscovery and scientific #innovation --> Order now at theKCGS.com
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