@ucielp

Group Leader of the Computational RNA Biology Lab

 Barcelona, Spain
chorosteckilab.github.io/
Joined September 2010
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🌱 Here we are again! Excited to share our latest review in TIBS: “The Expanding Functional Landscape of Alternative Splicing in Plants” 🔓 Free access until Oct 8: authors.elsevier.com/a/1ndnx… And stay tuned… October has more to bring! 👀🌱 @TrendsBiochem @ifibyne @unibielefeld
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Today I am so incredibly excited to share with you a new tool from the lab, #RFviewJS (and its stand-alone version #RFview). Two tools I built to fill a gap that has frustrated me for years. #RNA secondary structure visualization (1/n)
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1/ Excited to share our new paper in PNAS! 🌱 How does a plant decide which RNA isoform to make? We show that Arabidopsis SF1 rewires 3′ splice-site choice in vivo, shaping alternative splicing programs that impact both the circadian clock and immunity. pnas.org/doi/10.1073/pnas.25…

In vivo binding by Arabidopsis SPLICING FACTOR 1 shifts 3′ splice-site choice, regulating circadian...

Alternative splicing expands proteome diversity and enables phenotypic plasticity across eukaryotes. In plants, mutations in spliceosomal component...

pnas.org
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Great talk from an incredible scientist at Ribored! #RiboRed2026
Sociedad Española del RNA@ribored_esMay 14
Second scientific session started with Myriam Gorospe's keynote speech. Thanks for joining our meeting to share your latest research in RNA regulation
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Second scientific session started with Myriam Gorospe's keynote speech. Thanks for joining our meeting to share your latest research in RNA regulation – at Sant Feliu de Guíxols, Spain
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RiboRed Meeting 2026 is about to start! Follow us to keep updated during these amazing days
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Our first scientific session topic is "Therapeutic RNAs and RNA in disease". Our speakers have covered several diseases and innovative treatments. Thanks to all of them! Marc Talló-Parra, Lorea Blázquez, Aarón Ramirez, Ángela Pérez and Julián Valero.
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RiboRed 2026 begins! Great openning talk from Rory Johnson in lncRNAs
Sociedad Española del RNA@ribored_esMay 13
First keynote talk has held by Dr. Rory Johnson. Thanks for your attendance to our meeting and your engaging speech about lncRNAs architecture
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(1/2) Interested in plant evolution? We are opening two PhD positions in my lab at QGG - Aarhus University, where you will combine comparative genomics and machine learning to better understand and improve crop traits. #PlantSciJob #evolution #genomics
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#NuncaMas – at Rosario, Argentina
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Proud to be part of this collaboration with such an amazing team! We investigated how food acts not just as nutrition but as a carrier of stable informational molecules. Findings show human milk sRNAs can modulate cellular stress responses.
Silvana Spinelli@Silvana34754466Feb 11
Human milk contains a previously underappreciated layer of stable extracellular RNAs. Our new study in non-coding RNA @MDPIOpenAccess explores their abundance, stability, and biological activity under stress. doi.org/10.3390/ncrna1201000…
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The Spanish RNA Society (RIBORED) is officially here! Led by Alfredo Berzal, Encarna Martínez-Salas and Carles Suñé Negre. Visit our web to know more about us and follow our new social media channels to catch updates. #RiboRed2026 #RNA #RNAbiology #RNAspain
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Here we use In-cell NMR to study degradation of misfolded proteins in the periplasm of live bacterial cells 👇👇 A fun project with @TatoVila_1962 @rpierattelli, FJH y LJG! @IBR_CONICET @Plabem1 @cerm_cirmmp @fbioyfunr nature.com/articles/s41467-0…

Periplasmic protein quality control at atomic level in live cells

Nature Communications - In-cell NMR reveals the molecular details of NDM-1 degradation, an enzyme linked to antibiotic resistance, and sheds light on protein quality control in the periplasm of...

nature.com
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Excited to share our latest advances in RNA structural discovery at Harvard Medical School, with my kids there to share the moment. Huge thanks to Fede and @silvirouskin for the invitation and their expert feedback! it was truly inspiring.
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Among the pioneers in discovering and characterizing light sensing and physiological responses in bacterial chemotrophic pathogens such as Acinetobacter baumannii, we now show that these microorganisms exhibit light-modulated circadian rhythms. rdcu.be/eIQzL
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Large language models are reshaping the way we do science, but how well do they actually understand plant molecular biology? ➡️We created MoBiPlant to answer this. 📝Preprint: biorxiv.org/content/10.1101/… 💾Dataset: huggingface.co/datasets/manu… (Thread below)
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🪴 🤖 New preprint: What do LLMs know about Plant Molecular Biology? Take a look at MoBiPlant, our new benchmark to measure LLMs performance built by more than 100 plant scientist from 19 countries! More info in this thread 👇 xitter.cf/manuFernandezBu/status…
Manuel Fernández@manuFernandezBu8 Sep 2025
Large language models are reshaping the way we do science, but how well do they actually understand plant molecular biology? ➡️We created MoBiPlant to answer this. 📝Preprint: biorxiv.org/content/10.1101/… 💾Dataset: huggingface.co/datasets/manu… (Thread below)
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🌱🧬New preprint: What do LLMs know about Plant Molecular Biology? Take a look at MoBiPlant, our new benchmark to measure LLMs performance built by more than 100 plant scientists from 19 countries! Amazing collaboration! 🚀 More info in this thread 👇 xitter.cf/manuFernandezBu/status…
Manuel Fernández@manuFernandezBu8 Sep 2025
Large language models are reshaping the way we do science, but how well do they actually understand plant molecular biology? ➡️We created MoBiPlant to answer this. 📝Preprint: biorxiv.org/content/10.1101/… 💾Dataset: huggingface.co/datasets/manu… (Thread below)
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Riboswitches are super cool and the next frontier in RNA therapeutics !
Ronald Breaker@RonBreaker13 Aug 2025
#Guanidine was known since the 1870s to affect muscle function. Vertebrates have guanidine-sensing #riboswitch RNAs linked to genes relevant to muscle disorders, including some for Ca2+ signaling and others relevant to #ataxia symptoms. @NatureComms nature.com/articles/s41467-0…
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🚨 Buscamos candidatxs para postular a beca doctoral CONICET 2025 🌱 Tema: Regulación del crecimiento en plantas 📍 IBR Rosario | Dirige: Dr. Ramiro Rodríguez 🔬 Genética, genómica, biol. molecular y celular 📩 [email protected]
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