@trpa1study

retweeting information on TRPA1 research.

 Japan
Joined September 2016
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TRP Channel Cooperation for Nociception: Therapeutic Opportunities pubmed.ncbi.nlm.nih.gov/3297…

TRP Channel Cooperation for Nociception: Therapeutic Opportunities - PubMed

Chronic pain treatment remains a sore challenge, and in our aging society, the number of patients reporting inadequate pain relief continues to grow. Current treatment options all have their drawba...

pubmed.ncbi.nlm.nih.gov
The Role of DNA Methylation in Transcriptional Regulation of Pro-Nociceptive Genes in Rat Trigeminal Ganglia pubmed.ncbi.nlm.nih.gov/3297…

The Role of DNA Methylation in Transcriptional Regulation of Pro-Nociceptive Genes in Rat Trigemi...

Epigenetic modulation by DNA methylation is associated with aberrant gene expression in sensory neurons, which consequently leads to pathological pain responses. In this study, we sought to investi...

pubmed.ncbi.nlm.nih.gov
Identification of a new class of non-electrophilic TRPA1 agonists by a structure-based virtual screening approach pubmed.ncbi.nlm.nih.gov/3224…

Identification of a new class of non-electrophilic TRPA1 agonists by a structure-based virtual...

Recent work has gradually been clarifying the binding site of non-electrophilic agonists on the transient receptor potential A1 (TRPA1). This study searched for non-electrophilic TRPA1 agonists by...

pubmed.ncbi.nlm.nih.gov
TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice pubmed.ncbi.nlm.nih.gov/3280…

TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice - PubMed

Oxidative stress is implicated in retinal cell injury associated with glaucoma and other retinal diseases. However, the mechanism by which oxidative stress leads to retinal damage is not completely...

pubmed.ncbi.nlm.nih.gov
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Gating and calcium-sensing mechanisms of TRPA1 channels revealed pubmed.ncbi.nlm.nih.gov/3285…
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Photoactivatable Odorants for Chemosensory Research pubmed.ncbi.nlm.nih.gov/3286…

Photoactivatable Odorants for Chemosensory Research - PubMed

The chemosensory system of any animal relies on a vast array of detectors tuned to distinct chemical cues. Odorant receptors and the ion channels of the TRP family are all uniquely expressed in...

pubmed.ncbi.nlm.nih.gov
Upregulation of TRPM3 in nociceptors innervating inflamed tissue pubmed.ncbi.nlm.nih.gov/3288…

Upregulation of TRPM3 in nociceptors innervating inflamed tissue - PubMed

Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown. We induced unilateral...

pubmed.ncbi.nlm.nih.gov
TRPA1 enhances cortical sensory processing bit.ly/3hzZnJF
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TRPA1 regulates macrophages phenotype plasticity and atherosclerosis progression. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3232…
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Topical transient receptor potential ankyrin 1 antagonist treatment attenuates nociception and inflammation in an ultraviolet B radiation-induced b... - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3198…
Hypersensitivity to cold stimulation associated with regional osteoporotic changes in tail-suspended mice. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3202…
Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3111…

Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform...

Transient receptor potential ankyrin 1 (TRPA1), a membrane protein ion channel, is known to mediate itch and pain in skin. The function of TRPA1, however, in psoriasiform dermatitis (PsD) is uncert...

pubmed.ncbi.nlm.nih.gov
Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3191…

Sensitization of small-diameter sensory neurons is controlled by TRPV1 and TRPA1 association -...

Unique features of sensory neuron subtypes are manifest by their distinct physiological and pathophysiological functions. Using patch-clamp electrophysiology, Ca2+ imaging, calcitonin gene-related...

pubmed.ncbi.nlm.nih.gov
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TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3194…
The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP). - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3195…
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3186…
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#PainModulation | a cell-penetrating scorpion toxin targeting a #ChemoSensory Ion Channel #TRPA1 | David Julius @UCSF @CellCellPress buff.ly/2L3nW31
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Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors (Am J Respir Crit Care Med. 2019 Jun 7). atsjournals.org/doi/abs/10.1…

American Thoracic Society Journals

American Thoracic Society Journals

academic.oup.com
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Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/3117…

Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic...

ClinicalTrials.gov NCT02591550 .

pubmed.ncbi.nlm.nih.gov
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Isothiocyanates and Glucosinolates from Sisymbrium officinale (L.) Scop. ("the Singers' Plant"): Isolation and in Vitro Assays on the Somatosensory and Pain Receptor TRPA1 Channel. dlvr.it/R0l7gQ
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