TTM2 (2021) — In 1,861 unconscious adults after OHCA, hypothermia at 33 °C did not reduce all-cause mortality at 6 months compared with targeted normothermia (≤ 37.5 °C). trialsgram.com/trial/ttm2 #EBM #MedTwitter

RHAPSODY (2021) — In 86 patients with recurrent pericarditis and an elevated C-reactive protein level, continued weekly rilonacept prolonged time to first pericarditis recurrence compared with randomised withdrawal to placebo. trialsgram.com/trial/rhapsod… #EBM #MedTwitter

POST-4 (2021) — In 133 patients with recurrent vasovagal syncope and no serious comorbidity, midodrine reduced the proportion of patients with at least one syncope episode over 12 months compared with placebo. trialsgram.com/trial/post-4 #EBM #MedTwitter

LAAOS III (2021) — In 4,660 patients with atrial fibrillation undergoing cardiac surgery, surgical left atrial appendage occlusion reduced ischaemic stroke or systemic embolism compared with no occlusion. trialsgram.com/trial/laaos-i… #EBM #MedTwitter

EMPEROR-Preserved (2021) — In 5,988 patients with HFpEF (EF > 40 %), empagliflozin reduced HF hospitalisation or CV death compared with placebo. trialsgram.com/trial/emperor… #EBM #MedTwitter

EARLY-AF (2021) — In 303 patients with paroxysmal AF, first-line cryoballoon ablation reduced atrial arrhythmia recurrence compared with antiarrhythmic drugs. trialsgram.com/trial/early-a… #EBM #MedTwitter

DOREMI (2021) — In 192 patients with cardiogenic shock, milrinone produced similar rates of death and major complications compared with dobutamine. trialsgram.com/trial/doremi #EBM #MedTwitter

BIOSync CLS (2021) — In 127 patients aged 40 years or older with severe recurrent reflex syncope and tilt-induced asystole, a dual-chamber pacemaker with closed-loop stimulation reduced recurrence of syncope compared with the same… trialsgram.com/trial/biosync… #EBM #MedTwitter

ACST-2 (2021) — In 3,625 asymptomatic patients with severe carotid stenosis, carotid artery stenting produced similar rates of procedural death or disabling stroke and 5-year non-procedural stroke compared with carotid endarterectomy. trialsgram.com/trial/acst-2 #EBM #MedTwitter

VALOR-HCM (2022) — In 112 patients with obstructive HCM referred for septal reduction therapy, mavacamten reduced the need to proceed with or remain eligible for septal reduction therapy compared with placebo. trialsgram.com/trial/valor-h… #EBM #MedTwitter

STRONG-HF (2022) — In 1,078 patients recently hospitalised for acute heart failure, rapid up-titration of guideline-directed therapy with close follow-up reduced 180-day death or heart-failure readmission compared with usual care. trialsgram.com/trial/strong-… #EBM #MedTwitter

REVIVED-BCIS2 (2022) — In 700 patients with ischaemic LV dysfunction (LVEF ≤35%) and viable myocardium, PCI plus optimal medical therapy did not reduce all-cause death or HF hospitalisation compared with optimal medical therapy alone. trialsgram.com/trial/revived… #EBM #MedTwitter

PROTECTED TAVR (2022) — In 3,000 patients undergoing transcatheter aortic-valve replacement, the Sentinel cerebral embolic protection device did not reduce periprocedural stroke compared with no embolic protection. trialsgram.com/trial/protect… #EBM #MedTwitter

POISE-3 (2022) — In 9,535 patients undergoing non-cardiac surgery at risk of bleeding and cardiovascular events, intravenous tranexamic acid reduced life-threatening, major or critical-organ bleeding at 30 days, but non-inferiority for… trialsgram.com/trial/poise-3 #EBM #MedTwitter

FAME 3 (2022) — In 1,500 patients with 3-vessel coronary disease, FFR-guided PCI did not prove non-inferior for 1-year death, MI, stroke, or repeat revascularisation compared with CABG. trialsgram.com/trial/fame-3 #EBM #MedTwitter

DELIVER (2022) — In 6,263 patients with heart failure and an ejection fraction > 40 %, dapagliflozin reduced worsening heart failure or cardiovascular death compared with placebo. trialsgram.com/trial/deliver #EBM #MedTwitter

CHAP (2022) — In 2,408 pregnant women with mild chronic hypertension, antihypertensive treatment targeting a blood pressure below 140/90 mmHg reduced severe pre-eclampsia, medically indicated preterm birth, placental abruption or fetal… trialsgram.com/trial/chap #EBM #MedTwitter

BEST-CLI (2022) — In 1,830 patients with chronic limb-threatening ischaemia and infra-inguinal disease, surgical bypass reduced major adverse limb events or death compared with endovascular therapy, but only in those with an adequate… trialsgram.com/trial/best-cl… #EBM #MedTwitter

AVATAR (2022) — In 157 patients with asymptomatic severe aortic stenosis, early aortic valve replacement reduced death, MI, stroke, or HF hospitalisation compared with watchful waiting. trialsgram.com/trial/avatar #EBM #MedTwitter

TRILUMINATE (2023) — In 350 patients with severe symptomatic tricuspid regurgitation, transcatheter tricuspid repair improved quality of life compared with medical therapy. trialsgram.com/trial/trilumi… #EBM #MedTwitter