@trefely

Studying metabolic compartmentalization and metabolite signaling to the nucleus @BabrahamInst

 Cambridge, England
Joined March 2015
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  • Following516
  • Followers990
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We have an exciting postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬 The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️ For more detail and to apply: babrahaminstitute.livevacanc…
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Calling metabolism enthusiasts looking for a PhD opportunity! We have an exciting project in partnership with DefiniGEN Applications close Nov 24th findaphd.com/phds/project/in…

Investigating the impact of short chain fatty acids on hepatocyte nutrient handling at Babraham...

PhD Project - Investigating the impact of short chain fatty acids on hepatocyte nutrient handling at Babraham Institute (Cambridge), listed on FindAPhD.com

findaphd.com
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📣Only 1 week left to submit an abstract for the UK's leading #immunometabolism event! #UKimmunomet24 will be packed with cutting-edge #research, plenty of networking & 'Bright Sparks' sessions for #ECRs 🌟 Submit your abstract by Friday 15 March 👉bit.ly/3TUBIKl
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Trefely Lab retweeted
FrezzaLab@FrezzaLab7 May 2023
Good morning all! A very Ac-CoA-rich summary of papers in #cancermetabolism and #mitochondrialbiology is out now, don't miss it: biomed.news/bims-camemi/2023… @Bims_BiomedNews “The truth is not always beautiful, nor beautiful words the truth.” ― Lao Tzu
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Can histone deacetylation fuel acetyl-CoA metabolism? We teamed up with Ioana Soaita @AranyLab @mzspectrum @WellenLab to answer this question. jbc.org/article/S0021-9258(2…

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA–dependent metabolism

The ability of cells to store and rapidly mobilize energy reserves in response to nutrient availability is essential for survival. Breakdown of carbon stores produces acetyl-CoA (AcCoA), which fuels...

jbc.org
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We didn't detect any release into extracellular acetate, so we checked 13C-labeling. We found that up to ~10% of the acetyl-CoA pool was derived from deacetylation, and this label was transmitted downstream into (iso)butyryl-CoA!
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So the contribution of deacetylation to whole cell acetyl-CoA metabolism appears limited 🥲Although the contribution may vary across subcellular compartments. Variation in the extent of deacetylation between different histone lysine sites suggests selectivity in this response:
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Our data are consistent with a model where acetate is preferentially mobilized to maintain other acetylation events (such as shown recently by Mendoza et al @berger_lab @GarciaLabMS) pubmed.ncbi.nlm.nih.gov/3506…

Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sites -...

Histone acetylation is governed by nuclear acetyl-CoA pools generated, in part, from local acetate by metabolic enzyme acetyl-CoA synthetase 2 (ACSS2). We hypothesize that during gene activation, a...

pubmed.ncbi.nlm.nih.gov
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Trefely Lab retweeted
The Arany lab@AranyLab4 May 2023
Is histone acetylation really a reservoir for 2-carbon units to make acetyl-CoA? We used 13C tracing to show that ... yes, but not that much. Acetylation is dynamic but contributes only a little to cellular AcCoA demand. @WellenLab @mzspectrum @trefely authors.elsevier.com/sd/arti…
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Looking forward to Metabolomics chats in London 💂‍♀️
Cristina Legido-Quigley@DrLegidoQuigley17 Apr 2023
This Friday! @LdnMetaboNet spring meeting: 👉🏼Eight fabulous speakers experts in metabolism with #metabolomics #lipidomics💡 👉🏼🎫 register for free, 20 seats available of 100 👉🏼early career, Master and PhD candidates, senior folk all welcome 👉🏼Venue @KingsCollegeLon the Strand the science starts 12pm 👉🏼 The free networking event 6 pm to 9 pm #LMN🍋
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Thrilled to host the inaugural PhD student symposium on Cells, Plants, Food, and Healthy Ageing🌱🥙🦠🧫 @BabrahamInst Thanks to the wonderful students from BI and the EDESIA program @NorwichResearch @ClarkIM1965 for sharing their science - the future is bright!
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CLOSING TOMORROW: Join the @trefely lab as their new postdoc! The lab is focussed on the links between diet-derived metabolites and epigenetic regulation. Details: ow.ly/iW6250MKK9N #ScienceJobs #Careers #PostDocPosition
Postdoctoral Research Scientist (Epigenetics/Signalling) Starting salary is £33,970 per annum to £36,724 per annum

ALT Postdoctoral Research Scientist (Epigenetics/Signalling) Starting salary is £33,970 per annum to £36,724 per annum

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We are looking for a postdoc to join our team @BabrahamInst Join us to study the novel metabolic factors driving macrophage responses using iPSC models Details below, please share 🤗 babrahaminstitute.livevacanc…
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Happy to share my postdoc article @Nature from the Metallo lab @salkinstitute on the role of serine in the development of diabetes and its complications. It was an enjoyable and truly collaborative project @KnightLabNews @SatchinPanda @AChaix_UofUtah nature.com/articles/s41586-0…
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Trefely Lab retweeted
Rutter Lab
@RutterLab13 Jan 2023
Our latest Review on Metabolites as signaling molecules is now available @NatRevMCB. Co-Written by the incredible Steve Baker (@BakerLabUtah) @UofUPathology @ARUPLabs go.nature.com/3GGLRCk open access:rdcu.be/c3h4g @HHMINEWS @UofUBiochem

Metabolites as signalling molecules

Nature Reviews Molecular Cell Biology - Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic...

nature.com
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