@tmchartrand

neuroscience, data, math & computation @alleninstitute.

 Seattle, WA
Joined November 2016
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A couple weeks ago we quietly released a draft characterizing inhibitory neuron types in layer 1 of human cortex using patch-seq, and comparing to mouse! (w/ @KalmbachsCortex and many others) biorxiv.org/content/10.1101/…

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus...

Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary...

biorxiv.org
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More once we're through review - for now, feedback is welcome, including at our poster at #SfN22 4/4
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(and yes, I'm guilty of only tweeting papers😥. Sorry all, I'll try to learn sustainable engagement here soon, just in time for the platform's impending demise!)
On the Human Cell Types team, we study single neurons from tissue removed during surgery (thanks donors 🙏). We don’t usually get to study connections, so I jumped in to help with our SynPhys team’s analysis (science.org/doi/10.1126/scie…). 1/7

Local connectivity and synaptic dynamics in mouse and human neocortex

The temporal dynamics of interneuronal connections and local connectivity are analyzed in mouse and human brain slices.

science.org
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Other interesting species contrasts: human neurons recover faster from depression and have less variable responses. 6/7
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(disclaimer: 🐁 and 🤵 are different in many ways, so let’s not assume these findings are related to intelligence or human-unique. Who knows what we’d find in other species!) 7/7
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Just out in Science! Happy to have contributed to this project with @docseeman @lukecampagnola @timjarsky, thanks y'all.
allen institute@AllenInstitute10 Mar 2022
🧠 Which brain cell types are connected, and what do those connections look like? 🤔 Recording from multiple live neurons simultaneously — our researchers mapped thousands of cortical connections to find out. 🧵 1 alleninstitute.org/what-we-d…

How do our neurons connect? New study probes the details of human and mouse synapses

‘Multipatch’ technique catalogs more than 1700 connections between neurons in publicly released dataset

alleninstitute.org
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restarting this account, hello hello. will be tweeting about exciting science soon!
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