
Developing thiol compounds that are strong antioxidants for inherited mitochondrial diseases & related metabolic conditions like fatty liver disease etc. $TTI.v
Joined July 2022
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Welcoming Dr. Gilad Aharon (Rosalind Advisors) to the Thiogenesis Board. Continued alignment with specialist institutional capital. newsfilecorp.com/release/301… $TTI.V #cystinosis #leighsyndrome #cysteamine #raredisease #mitochondria . .
. newsfilecorp.com/release/299… Closed an oversubscribed C$9.07M financing.
Advancing TTI-0102 with significant milestones this year. Looking forward to getting into the clinic this summer — grateful for the continued support.
$TTI $TTIPF #Biotech #RareDisease
Excited to have CEO Dr. Rioux present positive MELAS data at Mitocon 2026 - proof of concept, biomarkers and early efficacy signals. $TTI.v $TTIPF #MELAS #Mitocon
newsfilecorp.com/release/281…
Thiogenesis Therapeutics retweeted
Taurine improves literally every metric of insulin resistance.
New review, finding taurine supplementation:
↓ Fasting blood glucose: −5.90 mg/dL
↓ HbA1c: −0.21%
↓ Fasting insulin: ~10-20%
↓ HOMA-IR: −0.57
↓ Triglycerides: −14.42 mg/dL
↓ Total cholesterol: −12.41 mg/dL
↓ LDL-C: −5.08 mg/dL
↓ Systolic BP: −4.38 mmHg
↓ Diastolic BP: −2.54 mmHg
↓ AST: −9.65 U/L
↓ ALT: −8.26 U/L
↓ CRP: 2-5 mg/L
↓ TNF-α: −0.35 pg/mL
Below I cover its protective mechanisms, other benefits and how to get enough in food + supps.
Thiogenesis Therapeutics retweeted
Inflammation is behind nearly every chronic disease—
From stubborn belly fat to heart attacks.
But no one talks about how to actually fix it.
Here are 10 underrated anti-inflammatory cheat codes your doctor won't mention:🧵
TTI-0102 is a precursor to hypotaurine which is oxidized into Taurine -- excellent summary below $TTI.v $TTIPF #taurine #mitochondria #MELAS #Leighsyndrome
Taurine is a sulfur-containing amino acid known for its critical involvement in skeletal muscle, heart and brain function. With high concentrations found in excitable tissues such as muscle, brain, and heart, taurine is essential for maintaining cellular homeostasis. It stabilizes cell membranes, acts as an osmolyte, and plays a central role in modulating intracellular calcium levels and ion channel activity. Taurine also exhibits significant antioxidant and anti-inflammatory properties, enhancing cellular resilience against oxidative stress and inflammation.
Taurine's actions span across multiple tissues and systems, including the central nervous system (CNS), heart, vascular system, immune system, liver, skeletal muscle, and pancreas:
*️⃣CNS: Taurine exhibits inhibitory actions, modulating neurotransmission and supporting neuroprotection.
*️⃣Heart: It enhances inotropy (heart muscle contractility) and provides anti-arrhythmic effects.
*️⃣Vascular System: Taurine contributes to vasorelaxation, blood pressure regulation, and the prevention of atherosclerosis.
*️⃣Immune System: It acts as an immunostimulant, supporting the body's defense mechanisms.
*️⃣Liver: Taurine aids in bile salt synthesis, essential for lipid digestion and absorption.
*️⃣Skeletal Muscle: Taurine enhances muscle performance by regulating calcium homeostasis, membrane excitability, and maintaining muscle phenotype.
*️⃣Pancreas: Taurine promotes insulin secretion, contributing to glucose regulation.
*️⃣Genitourinary System: It may also act as a fertility stimulant, reinforcing its wide-ranging biological importance.
Dosage recommendations, as depicted, range from 1-6 grams per day in clinical studies, with common supplementation protocols using 3-6 grams per day, typically split into two doses.
Taurine's toxicity is remarkably low, with human clinical trials supporting its safety even at high doses. Studies have highlighted taurine’s role in various pathological conditions, including cardiovascular and neurological diseases, making it an amino acid of great interest for its broad therapeutic applications and safety profile
Thiogenesis Therapeutics retweeted
The beauty of taurine beyond everything mentioned here is the fact that it has a sparing effect on nutrients tied to methylation (especially when saturated with all methylation nutrients) due to cysteine's metabolism down the transsulfuration pathway.
This means higher doses of taurine can not only spare magnesium—GABA—inhibitory effects in the central nervous system, but also spare small amounts of glutathione, methionine, choline/betaine, vitamin B2/B3/B9/B12, and glycine.
Not to mention that taurine is also greatly connected to supporting mitochondrial function and redox support. Thus, having an even further effect on this pathway.
Taurine appreciation post.
- It spares magnesium.
- Improves glutamate/GABA balance, shifting neurochemistry towards inhibitory tone - unlocking a calm/zen state.
- Huge benefits in mitochondrial function + redox.
- Supports bile flow (fat-soluble vitamins, fatty acids, detoxification)
- Supports glutathione production (indirectly via the transsulfuration pathway)
- Enhances neurogenesis via BDNF
- Increases blood flow via eNOS
- Organizes water/protein structures
- Optimizes glucose/fatty acid utilization towards a fat-burning/pro-metabolic state
- Reduces effects of blue light toxicity
- Buffers deuterium levels in mitochondrial matrix
3—5 grams, daily.
Eager to add a Phase 3 orphan program to the company's pipeline. $TTI.v $TTIPF #cystinosis #lysosome #orphandrug newsfilecorp.com/release/275…
Exciting news - interim phase 2 MELAS data, update on Leigh syndrome $ the introduction of a new late stage clinical program in cystinosis! $TTI.v $TTIPF #MELAS #cystionsis newsfilecorp.com/release/273…
Thiogenesis Therapeutics retweeted
The FDA has accepted Stealth BioTherapeutics’ third new drug application for its ultrarare disease candidate, providing a planned decision date of Sept. 26. fiercebiotech.com/biotech/fd…
Thiogenesis Therapeutics retweeted
The ORPHAN Cures Act will enable more options for Americans living with rare disease. Congress must pass the #ORPHANCuresAct to ensure continued investment in lifesaving treatments and to protect U.S. #biotech leadership.
Looking forward to filing IMPD for a Ph 2a pediatric MASH trial in the EU - an unserved market for kids with severe liver disease. $TTIV $TTIPF #mito #fattyliver #oxidativestress
newsfilecorp.com/release/256…
Great news today - excited to clear IND for LSS. $TTI.v $TTIPF #mitochondria #Leighsyndrome #cysteine #glutathione #IND newsfilecorp.com/release/255…
















