Cell-to-cell DNA transfer LAB Looking at Good Old Bacterial Sex!
Lyon
Joined March 2020
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C. LESTERLIN - TacC LAB retweeted
A recent preprint also from @eugene_koonin discovered that the restriction of HGT by defense systems is species-specific and depends on various ecological and genetic factors
biorxiv.org/content/10.1101/…
For those interested in "The Winding Journey of Conjugative Plasmids Towards a Novel Host Cell"
authors.elsevier.com/sd/arti…
C. LESTERLIN - TacC LAB retweeted
New paper! So pleased to see our Imaging + Deep-Learning way to rapidly detect antibiotic resistance out in Comm Biology rdcu.be/dq48G! Big thanks @AlexZagajewski @PiersTurner_! Wonderful collab w/Nicole Stoesser @OUHospitals & @CNellaker funded by
@oxmartinschool #AMR
New publication from the TacC Lab in collaboration with the Erhardt Lab. A long-awaited proof of DNA transfer via the extended conjugation pilus.
pnas.org/doi/10.1073/pnas.23…
C. LESTERLIN - TacC LAB retweeted
How RNAP keeps E.coli rolling with only a few rRNA "factories"? See our new NAR paper! Big thanks to Jun Fan (now PI at Chengdu) who led this in vivo single-mol work, and to all contributors, esp @HAFEZELSAYYED and @ojp25! academic.oup.com/nar/article…
New preprint from the Lab! Now we know ! The F pilus can serve as a conduit for the DNA during conjugation between distant cells biorxiv.org/content/10.1101/…
New BioRxiv pre-print from the TacC lab reporting the intracellular dynamics of plasmid transfer by conjugation in real-time. biorxiv.org/content/10.1101/…
After reconsidering with the help of my trusted scientific community, I have decided to step down from this guest-editor duty. Thanks to all and sorry for the poor decision timing.
Microorganisms Special Issue "The Stability and Plasticity of Genetic Information in Bacteria" is now open for submission.
mdpi.com/journal/microorgani…
I look forward to your contributions (research and review articles, as well as short communications)
The LAB coordinates the STARS-TAP project funded by the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR-HARISSA 2022-2025)
What about DNA-binding proteins' diffusion before/after chromosome degradation in E. coli cells?
Our new article is online:
authors.elsevier.com/sd/arti…
C. LESTERLIN - TacC LAB retweeted
RecA mediated homology search finds segregated sister locus in minutes after a double stranded break biorxiv.org/cgi/content/shor… #bioRxiv
C. LESTERLIN - TacC LAB retweeted
I think this is a very nice study which highlights both the strength (programmability and efficiency of CRISPR-Cas to kill strains or cure plasmids & protection against transfer of targeted mobile elements) as well as the main current limitation: limited transfer efficiency.
New reprint from our lab. An innovative antibacterial approach using conjugation to deliver CRISPR/Cas9 systems.
Targeted-Antibacterial-Plasmids (TAPs) combining conjugation and CRISPR /Cas systems achieve strain-specific antibacterial activity biorxiv.org/content/10.1101/…
C. LESTERLIN - TacC LAB retweeted
3 weeks to go -- waiting for your applications!
Waiting for your Chair applications, deadline Sept 14! Location? A brand new building, to be completed March 2021 (connected to the New Biochem bldg). Pls RT!
medsci.ox.ac.uk/images/suppo…
C. LESTERLIN - TacC LAB retweeted
The second paper from my PhD is finally out in @NatureMicrobiol! TraDIS on IncC conjugation.
Thanks to @pmduy,
@LabSchembri. Some really cool structural biology by Lou Zhenyao and Bostjan Kobe.
nature.com/articles/s41564-0…
