BioEmu2 is now available on web, API, and MCP!
Equilibrium ensemble sampling for proteins, nucleic acids & ligands — up to ~1,000,000× faster than traditional md simulation
github.com/microsoft/bioemu2
Got a molecular design idea? Send it over and have all work done for you, from concept to ranked candidates.
Use the new form, or DM here or @0xCF88
Join us next Wednesday for a webinar exploring what an AI-augmented research loop actually looks like in practice.
We'll cover which tasks are worth handing to a model, the mistakes that quietly cost people weeks, and how the scientist stays in control of the loop.
The science team at PeptAI will walk through the real architecture behind our peptide design.
RSVP now ↓
🧬 Protenix-v2 is now available on subseq
A high-accuracy all-atom cofolder for challenging antibody–antigen complexes, #3 on CoFold Arena, with optional physics-guided protein–ligand sampling.
github.com/bytedance/Proteni…
Available over web, API & MCP
Sign up for the webinar if you're interested in learning biomolecular design with AI agents and subseq computational tools
Every researcher is being told to use AI, but it can be super difficult to know where and how to begin.
We're hosting a live session with @peptai_ to help you bridge that gap. You'll leave with a working template you can put to use the same day.
Limited spots, RSVP below 🔗
New options for API keys on subseq:
- read-only, vs read/write
- optional project scope
This enables much more programmatic flexibility.
(Applies to all accounts, including teams)
🧬 OpenDDE is now available on Subseq
An open-source, all-atom model bringing IsoDDE-level co-folding accuracy to a reproducible framework—predicting multi-component complexes together.
github.com/aurekaresearch/Op…
AI agents are first-class users on Subseq. Connect your scientific agents to Subseq via MCP in just a few click and begin designing complex protein design campaigns.
Here's a short video connecting with Claude, and having it design a reusable binder design template👇
🧪 Pipelines got a major overhaul.
Run biomolecular campaigns repeatably, end-to-end with shared inputs and reusable templates. Compose from 20+ design, analysis, and simulation programs.
Protein Hunter is now live:
an experimental Boltz-edition workflow for iterative protein design.
Design binders against protein, small-molecule, or nucleic-acid targets, or run target-free generation from the same job interface.
source: github.com/yehlincho/Protein…
New program added: Proteina-Complexa
Recently released by NVIDIA BioNeMo, Proteina-Complexa offers atomistic generative binder design for protein targets, small-molecule ligands, motifs, and AME tasks.
source: research.nvidia.com/labs/gen…
subseq has no walled APIs 🚫
✅All workflows are open source and details can be copied / exported for full repeatability on your own hardware.
🧬 Genie 3 is now available on subseq
Run all-atom protein generation workflows for de novo backbones, motif scaffolding, and binder design from guided setup forms or custom configs.
Available over Web, API, and MCP for AI agents.
🧬 ESMC is now available
Generate protein sequence embeddings and masked-token scoring, useful for comparing proteins, featurizing variants, and ranking sequence plausibility.
Subseq has the tools for biomolecular design.
No subscriptions, just pay what you use. Available on web, API, and MCP server.
Try for free: subseq.bio
🧬 Evo 2 is now available on subseq
Run DNA language model jobs for sequence generation, likelihood scoring, and embedding extraction.
Available through the web UI, API, and MCP for agent-driven workflows.
Shape-Comp is now live
It computes the Lawrence-Colman shape complementarity metric used in Rosetta to assess protein-protein interface quality.
Useful as a fast screening step in protein design workflows.
Announcing subseq's new program interface!
Run any of the latest biomolecular models like ESMfold2 or Boltz-2 from a much nicer web interface.
Below is an example binder design for PDL1 using RFdiffusion3. Easy and fast.
Try it out today, new accounts get free credits.
🎆 Subseq MCP Server now supports OAuth 🎆
Now you can connect subseq directly to ChatGPT, Claude, and improved support for Claude Code and many other chat clients.
For most apps, just copy the mcp address:
subseq.bio/mcp
Full guide: subseq.bio/docs/mcp














