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Very glad to have contributed to this paper, which David Eisenberg (citing Churchill) called "the end of the beginning" in the fight to cure Alzheimer's - just published in @NatureComms!
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nature.com/articles/s41467-0…
Our new pre-print is out! The result of a wonderful collaboration with the Tanaka lab at RIKEN Center for Brain Science.
We investigate the question: what can yeast prions teach us about the connection between amyloid polymorphism and phenotype?
researchsquare.com/article/r…
David Boyer retweeted
How short peptides disassemble tau fibrils in Alzheimer’s disease: nature.com/articles/s41586-0…
David Boyer retweeted
FDA OKs the first blood test for #alzheimersdisease diagnosis. ow.ly/ths650VVlBf
David Boyer retweeted
First month as #newPI is in the books. Check out my lab website to learn more about the lab and opportunities. We have openings at all levels. If you are interested in cryoEM/cryoET to work on stress signaling pathways, please reach out.
sites.northwestern.edu/sangw…
Just created a “mock” grant on treating AD by eliminating or suppressing senescent cells. Now that I know what they are, I look forward to reading more about them. Seems like an interesting systemic approach to treatment.
There's keen interest in getting rid of senescent cells in the body to slow the aging process. One little problem: there are many types of these cells, some are quite beneficial, essential for repair or regeneration
cell.com/cell/fulltext/S0092… @CellCellPress
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I’ll be at #SfN24 for the next few days. If anyone who knows me is going, let’s meet up 😁
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Had a great time working with my group at the @_BrightFocus Alzheimer’s Disease Fast Track conference!
BrightFocus org, community, and mission are inspiring 😊
David Boyer retweeted
Divisions over lecanemab: keeping an open mind - The Lancet. Found myself nodding along to this editorial piece that takes a realistic and optimistic position about where we are and what is likely to happen re treatments. Refreshing. thelancet.com/journals/lance…
The hyperlink on citations that pulls up the source on the side bar on journal websites is one of technology’s greatest accomplishments.
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I believe it was shown that APOE does not adopt the helix bundle depicted in the image below under its physiologically-relevant lipidated state (cell.com/neuron/fulltext/S08…).
Going to read the review, but might need to be careful drawing conclusions from the helix bundle structure.
The latest on the APOE4 gene and #Alzheimer's disease, summarized so well @ScienceMagazine by @jocelynkaiser open-access
science.org/content/article/…
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Also, the Trump retort “so why didn’t you do it already” when responding to Kamala’s plans falls flat when even after 3 elections and 1 Presidency, Trump only has the “concepts of a plan” for improving health insurance.
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David Boyer retweeted
It's out in Cell!!! Super proud bug- and structural virologist moment; my paper about using CryoEM to discover, diagnose, characterize, and mitigate a nationwide agricultural pandemic is now published online 😄🐛🪲
cell.com/cell/fulltext/S0092…
My fiancé is making a short film called Aptitude about a future with AI-driven standardized testing with a beautiful human story at the center. If you have a few minutes, you can help her and her team raise funding by signing up and voting on this site: artizen.fund/index/p/aptitud…
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David Boyer retweeted
Clinical use of anti-amyloid antibody Leqembi is growing fast, and may soon overwhelm the capacity of dementia clinics to take on new patients. #alzheimersdisease ow.ly/9Ixg50QuWh5
David Boyer retweeted
We are thrilled to present a new #enzyme to the world, the first shown to break the man-made carbon-silicon bonds in #siloxanes, which are persistent in the environment.
caltech.edu/about/news/teach…
David Boyer retweeted
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation: sciencedirect.com/science/ar…
David Boyer retweeted
Science communication is treated like DEI (no funding, not respected by the boys’ club) and it’s a hugeeeee mistake we will all regret in 20 years.
David Boyer retweeted
Just in time for Sunday's CicLAvia, UCLA Bike Shop is back and better than ever. Stop by UCLA Recreation's shop on the north side of the John Wooden Center for DIY and full-service fixes. newsroom.ucla.edu/stories/uc…
David Boyer retweeted
I stand in strong solidarity with @sagaftra.