@strained_rings

Strain chemistry insights | Recent papers, perspectives & breakthroughs | Where molecular stress meets discovery 🔬 Handled by @HariGroupIISc

 Bangalore, India
Joined January 2026
  • Tweets168
  • Following99
  • Followers753
12Media
Strained Rings retweeted
Gaurang Bhatt, Ph.D.@GaurangMSUSep 23
BCBs continue to surprise us! 🧪 We report a distinct mode of reactivity that harnesses cooperative NHC/Lewis acid catalysis for the controlled strain-release geminal difunctionalization of bicyclo[1.1.0]butanes (BCBs). @strained_rings Pl Read here: lnkd.in/dk-4PjPu
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Is it azetidine or piperidine? Or maybe both? One thing is for sure – this is a stable crystalline solid!
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Strained Rings retweeted
YD Group@YDGroup_IITRSep 17
Recent work appeared in #OraganicLetters@JOC_OL on “Bicyclo[1.1.0]butane Carboxamides to N-Heterocycles via Nickel(II)–Carbene Intermediate” from @ChemIITR @iitroorkee Congratulations to @Akanksha7babbar and @gauravy1006 Thanks to @ANRFIndia for funding pubs.acs.org/orlef7/article/…

Bicyclo[1.1.0]butane Carboxamides to N-Heterocycles via a Strain Release-Enabled Nickel(II)–Carbene...

Abstract. We report the conversion of bicyclo[1.1.0]butane carboxamides into N-heterocycles via strain release, enabling the generation of a novel class of

pubs.acs.org
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Strained Rings retweeted
Wipf Group@wipf_groupSep 12
⚡️⚡️⚡️chiral tetrasubstituted BCBs from alkynes and carbenes⚡️⚡️⚡️Stereoselective polysubstituted bicyclo[1.1.0]butane synthesis by rhodium-catalyzed kinetic resolution | Science science.org/doi/full/10.1126…
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Now online: Enantioselective synthesis of chiral 2-azaspiro[3.3]heptanes and their application as piperidine bioisosteres go.nature.com/4imjXQq 🧪
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Strained Rings retweeted
Nature Synthesis@NatureSynthesisSep 9
Now online: Strain-release strategy for access to diverse azabicyclic bioisosteres go.nature.com/3UCldFn 🧪
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Strained Rings retweeted
Chandra Volla@ChandraVollaAug 31
Please see our recent work on Electron Donor-Acceptor (EDA) driven radical cascade consisting of cyclization, SO2 insertion, radical addition to BCB followed by radical cyclization. Congratulations to @Jatin_Patra5 and @Kousik Saha for steering the work. pubs.acs.org/orlef7/article/…
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Now online: Combining CO2 and bicycloalkanes for polyester production go.nature.com/4qF9bGV 🧪
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Strained Rings retweeted
ATBiju Group@ATBijuLabSep 5
Just out @NatureComms, our work on visible-light mediated double strain-release Alder-ene reaction of BCBs🦋 with cyclohexynes to skipped dienes and remodeling to tetralines. Congrats @123shashankkk for nice work👏, funded by @serbonline👏! @iiscbangalore rdcu.be/TnJW5rg1pHKa
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Strained Rings retweeted
KoenigChemistry@ChemistryKoenigAug 28
Beyond thermodynamics into 3D! @angew_chem Congratulations to @NayanSahaChem and @Rueping_Lab! A de-novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly-Controlled Kinetic Electron Transfer Gating doi.org/10.1002/anie.2936884
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Strained Rings retweeted
ATBiju Group@ATBijuLabAug 14
We can now perform the cross-coupling of electronically different BCBs🦋for selective access to cyclobutyl cyclobutenes, just out in @ACSCatalysis😃! Nice work by @deeptanu_2 & @KamalakshiB1103👏! We thank @serbonline for funding 🙏! @iiscbangalore pubs.acs.org/accacs/article-…
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🦋 Enantioselective single-atom skeletal editing harnesses highly strained bicyclo[1.1.0]butanes for carbene insertion, forging architecturally sophisticated chiral scaffolds through precise molecular reconstruction 🚀 @NatureSynthesis doi.org/10.1038/s44160-026-0…

Enantioselective single-atom skeletal editing of bicyclo[1.1.0]butanes by carbene insertion

Nature Synthesis - Owing to competitive strain-induced ring-opening and isomerization side reactions, enantioselective single-atom skeletal editing of saturated carbocycles, particularly bridged...

nature.com
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Strained Rings retweeted
Waser Group@LcsoLabJul 10
"Strained ring preprint hat trick" at @LcsoLab with the last work of @CarloBalda97 with @IBMResearch @NCCR_Catalysis on the aminoarylation of cyclopropanes using complementary photo- and copper-catalyzed approaches now available at @ChemRxiv doi.org/10.26434/chemrxiv.15…
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🦋Radicals and diradicaloids harness the latent energy of strained cycloalkanes, revealing how diradical character and strain release dictate reactivity, selectivity, and molecular complexity 🧪🚀 @J_A_C_S @GargLab @houk1000 pubs.acs.org/doi/10.1021/jac…

Reactions of Strained Cycloalkanes with Radicals and Diradicaloids: The Roles of Diradical Charac...

Abstract. Ring-opening reactions of strained cyclic alkanes are powerful methods to construct complex organic molecules. Strain release, quantified by the

pubs.acs.org
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🦋 Tunable Pd catalysis exploits vinylbicyclo[1.1.0]butanes to orchestrate divergent [2π+2σ] cycloaddition/Alder-ene pathways, forging architecturally sophisticated, strain-rich heterocycles with precision ⚡️ @JOC_OL doi.org/10.1021/acs.joc.6c00…

Tunable Palladium-Catalyzed [2π + 2σ] Cycloaddition/Alder-Ene Reactions of Vinylbicyclo[1.1.0]but...

Abstract. A condition-controlled regiodivergent [2π + 2σ] cycloaddition/Alder-ene reaction of vinylbicyclo[1.1.0]butanes with cyclic N-sulfonylimines enabl

pubs.acs.org
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Strained Rings retweeted
Nature Catalysis@NatureCatalysisJul 9
Triple energy transfer-enabled dearomative cycloaddition/rearrangement cascade of bicyclic azaarenes to structurally complex products dlvr.it/TTQv91
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Strained Rings retweeted
Waser Group@LcsoLabJul 1
A convergent access to medium-size rigidified nitrogen heterocycles: Have a look at the last work of Stefano Nicolai and Daphne Lucidarme on the annulation of bicyclobutanes and azadienes to give azabicyclooctanes now as a preprint at @ChemRxiv chemrxiv.org/doi/full/10.264…
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🦋 Enantioselective diastereodivergent coupling of aldehydes with highly strained bicyclo[1.1.0]butanes unlocks precise access to architecturally complex cyclobutanes with exceptional chemo- and stereoselectivity 🚀 @OrgChemFront doi.org/10.1039/D6QO00662K

Enantioselective diastereodivergent reactions between aldehydes and bicyclo[1.1.0]butanes

Developing diastereodivergent and enantioselective catalytic reactions to access structurally and stereogenically diverse molecules from identical starting

pubs.rsc.org
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C═C/N═O metathesis enables oxidative decarboxylation, rapidly forming strain-rich molecular intermediate via elegant bond reorganization and expanding the horizons of modern synthetic chemistry ✨ @J_A_C_S @morandilab doi.org/10.1021/jacs.6c08509

C═C/N═O Metathesis Enables Oxidative Decarboxylation

Abstract. Metathesis reactions proceeding through a (2 + 2) cycloaddition – (2 + 2) cycloreversion sequence are of great importance in synthetic chemistry.

pubs.acs.org
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🦋⃤ Cyclopropene–allene metathesis exploits the exceptional reactivity of strained cyclopropenes to forge axially chiral skipped ene–allenes bearing quaternary stereocenters with remarkable diastereocontrol ⚡️ @angew_chem onlinelibrary.wiley.com/doi/…

Diastereoselective Synthesis of Axially Chiral Skipped Ene–Allenes Containing a Quaternary Stereo...

Catalytic ring-opening metathesis between mesomeric cyclopropenes and terminal allenes yielded skipped ene–allenes featuring a diastereogenic axis and an acyclic quaternary stereocenter. These...

onlinelibrary.wiley.com
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