An international partnership to implement a new two-in-one medicine for #helminthiasis. #beatNTDs
Joined August 2023
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#STOP2030 at a glance! ▶ Discover our project and meet the partners with our newly launched presentation video.
All you need to know about our novel co-formulation for #STH in under 5 minutes — watch now!
youtu.be/7khmmuMyEnQ
Thank you to everyone who contributed to this achievement, especially our partners @_GHSofficial | @KEMRI_Kenya | @Chemo_Pharma | @ISGLOBALorg | @bridges2develop | @sangerinstitute | @MundoSano #NTDs #WorldNTDday #globalhealth @EDCTP3
From the start, the STOP projects have aimed to advance an innovative tool to fight STH infections. Now, with our fixed-dose coformulation in Phase IV trials, we’re closer than ever to delivering a new medicine for NTD control goals!
🌍 Learn more👉 stop2030.org/project/
Over 20 countries run national #deworming programmes 🌍These efforts are primarily concentrated in Africa, with several countries targeting millions of children to control #STH infections. These programmes are vital to improving children's healthy development.
Check out our latest interview! 💬 Our coordinator, Dr Alejandro Krolewiecki, was at Contagion Live talking about our co-formulation and the opportunities it can bring to endemic countries! Watch the whole interview here contagionlive.com/view/tackl…
Combining #ivermectin and albendazole outperforms albendazole monotherapy for Trichuris and hookworm, according to a new meta-analysis. The combination shows higher effectiveness against more species while maintaining a similar safety profile. journals.lww.com/md-journal/…
Get the latest data on soil-transmitted helminths (STH) prevalence in Africa
This study takes a deep dive into existing ESPEN data to analyse the spatial distribution of STH across 35 African countries.
By developing geostatistical models, the research highlights the environmental factors that influence STH prevalence.
Check out the full paper for more details! journals.plos.org/plosntds/a…
We are incredibly proud to be highlighted as one of the projects in this story about EDCTP and its 20-year anniversary.
@EDCTP3 embodies what public-private collaboration should be, and enables us to walk the path from research to results.
sciencebusiness.net/news/edc…
Do we need a new approach to STH treatment?
❌ Current treatment used in mass drug administration shows poor efficacy against some species.
⚠️ Using only one drug type increases the risk of resistance emergence—a major challenge in infectious disease control.
Albendazole monotherapy has been the standard for mass drug administration campaigns to control soil-transmitted helminths (STHs) for over a decade — but it’s no longer enough.
Take this recent study from Ethiopia 👇
While albendazole showed strong efficacy against hookworm (94.1% egg reduction), it performed poorly against Trichuris trichiura (just 31%).
This highlights the urgent need for updated treatment approaches that are effective across all STH species.
📄 Read the full study link.springer.com/article/10…
The results of over a decade of progress.
Our journey for a better treatment for soil-transmitted helminths started in 2010, with a pilot project in Northern Argentina.
Since then, several studies, clinical trials, and partnerships have shaped the development of our fixed-dose combination of #ivermectin & #albendazole. Want to see how far we’ve come?
📖 Explore the full scientific timeline here 👉 stop2030.org/publications/
STOP2030 retweeted
How can we simplify drug delivery for #NTDs?
Our @stop2030project analysed data from 700,000+ people across 53 countries showing that fixed-dose ivermectin could make mass drug administration easier, fairer & more efficient.
🔗 journals.plos.org/plosntds/a…
Today we’re presenting our fixed-dose co-formulation of ivermectin and albendazole (FDC) at the Innovation Fair 2025 in Brussels — an event that brings together innovation ecosystems from Europe, Africa, and the Mediterranean.
Alejandro Krolewiecki, our PI, will give a pitch on the innovations behind the combination of these two drugs: a new dosing strategy that simplifies logistics, enabling the control of more species, all in a one-per-person tablet that dissolves with saliva.