Longevity scientist / Author of https://xitter.cf/t.co/b7cDbmWGKN / Presenter https://xitter.cf/t.co/ChpWwP9GqY / Co-Founder and Director @longevityinit

Berlin, DE
Joined May 2007
Ageless: The new science of getting older without getting old is out in paperback! ‘A tour de force of anti-ageing science’ – @thetimes ‘A fascinating look at how scientists are working to treat the aging process itself’ – @drsanjaygupta Buy a copy at andrewsteele.co.uk/ageless/
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Andrew Steele retweeted
El científico Andrew Steele, autor de “Ageless: La nueva ciencia de envejecer sin hacerse viejo” y director de The Longevity Initiative, inaugura las ponencias de #ADINBERRI Longevity Forum 2026. @AdinberriFund
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Andrew Steele retweeted
🗣️@joncylus: “Older workers can remain productive as long as they stay healthy. Their work can continue to contribute to the economy” #AdinberriLongevityForum
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Our Director @statto opened the @AdinberriFund Longevity Forum this morning in Donostia / San Sebastián, Spain. Spain has a life expectancy of 84, which is one of the highest in the world—so it’s an especially important place to discuss longevity science and policy.
🗣️ @statto: “I think most of us know that older people are more likely to die, but just how much really shocked me” 🔬 The scientist opens #AdinberriLongevityForum with the latest advances in ageing science and the potential to live longer, healthier lives.
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Andrew Steele retweeted
🗣️ @statto: “I think most of us know that older people are more likely to die, but just how much really shocked me” 🔬 The scientist opens #AdinberriLongevityForum with the latest advances in ageing science and the potential to live longer, healthier lives.
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Excited to speak at the @AdinberriFund Longevity Forum today! Spain has one of the world’s highest life expectancies—and I’m going to be talking about the longevity science that could keep Spaniards even healthier for even longer!
🌊 #AdinberriLongevityForum 2026 hastear da! 🎤 @nerea_melgosa eta @maitepenalopez arduratuko dira irekiera instituzionalaz. Ondoren, @statto-k emango dio hasiera hitzaldi-programari, zahartzeari eta longebiteari buruzko azken aurrerapen zientifikoak aurkeztuz.
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People, including doctors, trust AI too much. It’s automation bias: ‘computer does arithmetic with perfect speed and accuracy’ is a good heuristic, but has transferred across to much fuzzier tasks.
Even with physicians "in-the-loop," in this case experienced specialists, adversarial AI increased the harmful decision rate from 2 to 49%. A randomized assessment of case scenarios, not actual patients, but indicative of the limitation of oversight. preprint medrxiv.org/content/10.64898…
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Andrew Steele retweeted
Now that we know aging interventions can be developed, it makes sense to view aging itself as a root cause of disease It has of course always been…
If they added ‘ageing’ proper to this, rather than somehow separating out the ‘unhealthy’ part, it would dwarf all the other bars…
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If they added ‘ageing’ proper to this, rather than somehow separating out the ‘unhealthy’ part, it would dwarf all the other bars…
This has to be the most interesting and sobering paper of the year. It estimates the global health impacts across all measurable threats to health to 2100 using amenable disability adjusted life years (DALYs). The leading threat to health? Obesity, including high BMI, poor diet, and low physical activity. Food systems are one of the key ways to address obesity and other leading threats to health in the 21st Century. thelancet.com/journals/lance…
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Andrew Steele retweeted
‼️ Azken sarrerak #Adinberrilongevityforum-erako 🗣️ @statto, @joncylus, Cristina Garmendia, Iñaki Gabilondo, Karen Wee eta @Emilio_Duro_ Kursaalen izango dira urriaren 14an eta 15ean. 👉 Eskuratu zure sarrera! 👉🏻labur.eus/1jwrybpf
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The rule for awarding a Nobel to three living recipients makes for some pretty unfair prize-ing…
Nobel Prize for optogenetics shared by 3 (Deisseroth, Nagel and Hegemann). There will 'oh-so-close' feelings at MIT by the first author of Deisseroth's paper, the prominent neuroscientist Edward Boyden. /more
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This is another issue! Just need to wait for two of them to die, which is a bit morbid…and their own therapy might make less likely! xitter.cf/vivienneparry/status/2…
Replying to @statto
The just 3 rule also shuts out some deserved winnners…like for discovery of GLP1s. Dan Drucker and Jens Holst for sure but 3rd place could be one of a cast of at least 5 which may mean none will have Nobel.
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Andrew Steele retweeted
A failure of the AI consciousness discourse is that people are talking past each other. Opponents of taking AI consciousness seriously focus on arguing against computational functionalism and related theories. But this is not a response to the proponents. The case in favor of taking AI consciousness seriously is not that computational functionalism or related theories are correct, or that AI systems on current architectures are or will be conscious. Most people who work on the topic are uncertain about these claims. The case is instead that, first, whether AI systems are conscious is an important issue. If we get it wrong in either direction, either by treating conscious systems as objects or by treating nonconscious systems as subjects, we could make serious mistakes. Second, this is also a difficult issue. It touches some of the hardest problems in science and philosophy, and humans have been badly mistaken about nonhuman consciousness in the past, as our shameful history of underestimating animal minds illustrates. Together, these points mean that this issue calls for caution and humility. Rather than confidently affirming or denying AI consciousness, we should invest in evidence-based research and policy that can help us avoid both under- and over-attribution. Moreover, we should develop this work with not only current but also future systems in mind. AI development is moving fast, and future systems may have greater capabilities, greater autonomy, and more biology-inspired architectures than current ones. We should prepare for the possible emergence of such systems now, rather than be caught flat-footed if and when they arrive. Rejecting this case thus requires more than showing that consciousness on current architectures is unlikely. It requires showing that AI consciousness on current *and* future architectures is *so* unlikely that we should neglect the topic entirely, notwithstanding its importance and difficulty. This level of confidence is simply not warranted in either direction at this early stage. To be clear, this is not a response to people who are merely skeptical that AI systems on current architectures are or will be conscious. There are good arguments for and against a range of theories, and I share this skepticism myself. It is instead a response to people who dismiss the topic altogether, and who disparage those who take it seriously as naive or as zealots. Here are a few resources that discuss these issues at a high level: aeon.co/essays/an-ant-is-dro… ai-frontiers.org/articles/a-… youtube.com/watch?v=yEfvhjuj… And here are a few resources that discuss these issues in more detail: link.springer.com/article/10… arxiv.org/abs/2411.00986 nonhumanminds.org/studying-a…
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Andrew Steele retweeted
Very cool work. Systematic screening finds a new transcription factor normally on in development. But seems to protect against aging when re-activated.
1/ Excited to share our new preprint from a joint collaboration between @JswLab + @Bruce_Ksander! Aging is marked by a progressive loss of resilience to stress. Can we systematically search the human ORFome for genes that make vulnerable cells more resilient? Performing such a genome-scale ORF screen led us to NKX2-5—a heart transcription factor we engineered to restore vision, and improve health in aged mice. A breakdown🧵 🔗 doi.org/10.64898/2026.09.29.…
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Ageless just hit 1000 ratings on Amazon! (I noticed because someone I got chatting to on a plane whipped out his phone to buy a copy!) Glad to see it’s still moving almost five years after it was first published. :)
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I wish there had been so much progress that it was all totally dated, but alas I think it is still a good general overview of the field. You can find out more, and buy it from Amazon or elsewhere at ageless.link/ :) (Feel free to leave a rating so I can blast past 1k!)
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I guess it’s better than “non-functional”
Put “functional” in front of anything and you have my attention.
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Andrew Steele retweeted
Tip for journos. Don't ask politicians whether they oppose Labour's Triple Lock replacement, ask them what share of average earnings they think pensions should be. If they really support the status quo, they'll say: "Far higher than currently at an essentially random pace."
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I sadly can’t make it, but if you’re in Boston and want to chat longevity policy, regulation, funding and communication, please do grab a meeting with my @longevityinit colleagues Kamen and Sophie! We’re fundraising and looking for collaborators: xitter.cf/longevityinit/status/2…
The longevity science community is converging on Boston for @ARDD_Meeting and @agingbiomarkers, and The Longevity Initiative will be there! Our Director @shoylev and Researcher Sophie Shrimpton will be at the conference to catch up on the latest research, and with the people moving longevity science out of the lab. We’re fundraising, and looking for collaborators to bring regulation and public understanding up to speed with the latest breakthroughs in longevity science. We’d also love to hear your thoughts on the highest-impact things we could be working on. If you’d like to arrange to meet, you can grab a slot here: cal.com/thelongevityinitiati… See you in Boston!
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So…er…do you have any arguments as to why instrumental convergence wouldn’t happen, or is it just that lots of people who disagree with you believe it therefore it must be the tenet of a cult?
Contra @slatestarcodex, my arguments against AI doomerism have never been based on the claim that it is a cult. But the responses to my open letter (together with journalistic digging by NYT and WSJ) have made this more plausible. Foremost is the invocation of tenets in the doomer catechism (particularly "instrumental convergence," the belief that intelligent agents will inevitably seek power, resources, and self-preservation as subgoals) as if they were sacred truths rather than tendentious assumptions. (IC is in fact the not-so-intelligent pursuit of a goal heedless of side effects, and the reckless empowerment of AI, that we un-doomers note are deliberate, hence avoidable, design choices, not intrinsic constituents of intelligence). I feel as if I'm doubting the Second Coming and am being told, "That's naive and ignorant; you seem to be unaware that the Apostles' Creed dictates that it will happen."
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We need to think a lot more seriously about pensions policy, and take into account that many of us might live much longer, healthier lives thanks to longevity science. For a start, the triple lock is problematic:
However high you want the state pension to be, the ‘triple lock’ is awful way to achieve it It ratchets up value of state pension in an unpredictable way - could reasonably be expected to push up spending by anywhere between £5bn & £40bn a year in 2050
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It looks like @TheIFS’s suggestion, except the flat bits are replaced by 2.5%/inflation-sloped bits until earnings catch up.
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I guess the inflation slope is defensible—stuff you’re buying is getting more expensive, so you need more money. The 2.5% seems more arbitrary!
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