📲Explore here the 3D world of #Spirocycles. 🧪 Decoding Structure • Synthesis • Applications in Modern Chemistry. 🧬 Follow for recent #publications📰
Joined December 2024
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Mousanes: three cyclobutanes, two spiro junctions, one highly constrained scaffold. ⚡ A convergent [2+2] strategy delivers versatile dispirodecane building blocks for amino acids, diamines, diols, drug analogues & degraders. @bmsn 🔗chemrxiv.org/doi/full/10.264…
A Stereoretentive Norrish–Yang Photocyclization reported by @MelchiorreGroup @JACS. This method is applied to the synthesis of enantiopure spirocyclic-cyclobutanols.
🔗pubs.acs.org/doi/10.1021/jac…
Spirocycles retweeted
Super-strained spirocycles meet AI-supported target fishing. ⏹️🤝🎣
We introduce a new class of "super-strained" spirocycles which through AI-supported target fishing (@CASChemistry) were found to be agonists for the sigma-1 receptor. 💊
Now in @angew_chem
Link in comments👇
✨Strain meets function
One-step addition/spirocyclization of imines + bicyclobutanes delivers azaspiro[3.3]heptanes—versatile bioisosteres with rapid access to diverse spiro frameworks.
@leitchlab
@uvic
🔗chemrxiv.org/doi/full/10.264…
⚡Hydride abstraction drives the show
Allylic alcohols/silyl ethers enable a Prins–semipinacol cascade to build spirocyclic ethers with high stereocontrol.
pubs.acs.org/doi/10.1021/acs…
🎈CO₂•⁻ powers the cascade
First SET–HAT–SET relay in cyclopropanation delivers spirocyclopropane-γ-lactams—mild, broad scope, and 3D scaffold ready.
pubs.acs.org/doi/10.1021/acs…
Spirocycles retweeted
Registration is now open!
🚨 Don’t miss your chance to join us in Alicante and meet our confirmed plenary speakers!
👉 Stay tuned for more details!
photocat2026.com/registratio…
💡Carbyne reactivity
Light-driven cascade controls radical → nucleophilic → electrophilic steps to forge spirocyclic ethers with three σ-bonds at one carbon—modular, scalable, and highly selective. 🧪
@angew_chem @NUSingapore
🔗onlinelibrary.wiley.com/doi/…
Chiral η⁶-benzene ligands level up ⚡
New binaphthyl–Ben–Ru(II) catalysts enable phenol-directed asymmetric C–H activation, delivering spirocycles with quaternary centers in up to 99% yield & 97% ee. 🧪✨@J_A_C_S @sysu_1924
🔗pubs.acs.org/doi/10.1021/jac…
⚡Nickel unlocks new spirocyclic chemical space ⚡
Divergent arylative cyclization of unactivated alkenes delivers heteroatom-substituted spirocycles with excellent regio- and trans-selectivity—broad scope and drug-relevant scaffolds. @CCSChemistry
chinesechemsoc.org/doi/10.31…
⚡Rh₂(S-p-PhTPCP)₄ enables asymmetric [2+1] cyclopropanation of diazo lactones/lactams → spirocyclopropanes with up to 98% ee and 1.7M TON. Powerful route to 5-oxa/5-azaspiro frameworks.
@EmoryUniversity @j_a_c
pubs.acs.org/doi/10.1021/jac…
⚙️Rigid & bioactive ⚛️
A chiral proton shuttle strategy unlocks enantioenriched spirobarbiturates via barbituric isothiocyanates + enynamides—mild conditions, high ee, and mechanistic insight from kinetics & DFT.
🔗pubs.acs.org/doi/10.1021/acs…
Breaking flat aromatics into 3D 🔥
I(III)-mediated phenol dearomatization unlocks all-carbon spirocycles (3–6 rings!) with tight chemo-/regiocontrol—plus easy access to fused bicyclics. 🧪
🔗pubs.acs.org/doi/10.1021/jac…
Seven steps, >99% ee, multi-hundred-gram scale 💪
Asymmetric allylic alkylation + Mitsunobu magic delivers a chiral oxa-azaspirocycle in 42% overall yield. 🔄
@boehringerus @ACSPublications
🔗pubs.acs.org/doi/10.1021/acs…
Turning stubborn methyl C–H bonds into opportunity ✨
Ligand control unlocks β-methyl C(sp³)–H functionalization, delivering diverse spirocyclic lactones, dihydrocoumarins & ketones, straightforward from cyclic acids. 🧪
@YulabJin @J_A_C_S
🔗pubs.acs.org/doi/10.1021/jac…
💹Enantioselective, organocatalytic, diastereodivergent synthesis of spiro-fused coumarins via trienamine Diels–Alder reactions, with additive-controlled reversible diastereoselectivity and 💻DFT insight.
@JOC_OL @ACSPublications
pubs.acs.org/doi/10.1021/acs…
🟥Spirocycles are sp³-rich, high-value motifs in synthesis and drug discovery. An H-bond-directed photochemical strategy enables access to densely substituted spirocyclic architectures, expanding the toolbox for spirocycle construction.💡
@JOC_OL @ACSPublications
pubs.acs.org/doi/10.1021/acs…
N,O-Spirocycles!
🎯Pd-catalyzed enantioselective dearomatization of bromofurans with N-tosylhydrazones using a newly developed chiral sulfinamide phosphine ligand. @JOC_OL
🔗pubs.acs.org/doi/10.1021/acs…
💡Light-driven Birch-type reduction/spirocyclization unlocks rapid access to sp³-rich spirocycles from simple arenes—under mild, organocatalytic conditions. A powerful new route to medicinally relevant 3D scaffolds. 🧪by @MelchiorreGroup
@J_A_C_S
🔗pubs.acs.org/doi/10.1021/jac…
Spirocycles retweeted
Great highlight in our #Synlett cluster 💠𝗠𝗼𝗱𝗲𝗿𝗻 𝗛𝗲𝘁𝗲𝗿𝗼𝗰𝘆𝗰𝗹𝗲 𝗦𝘆𝗻𝘁𝗵𝗲𝘀𝗶𝘀 𝗮𝗻𝗱 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻💠 edited by @TomislavRovis, @DrLCsquare
#photoredox #spirocycles #radicals #hydroarylation #mostread @Jui_Group 👉fal.cn/3d34P
