What’s stopping you from buying this Detroit home for only $1,999,000?

About 15% of ~40,000 people who developed cancer have pathogenic (disease-causing) genome variants (PVs) when their DNA was sequenced. That's a big proportion of cancer that would set up prevention or very early detection which is completely missed today @AACR @CD_AACR aacrjournals.org/cancerdisco…

This is insane. THREE different Hurricane forecast cones are now simultaneously aiming at the North American continent.

“Fires break out” “Fight between pilots” The BBC, ladies and gentlemen.

AGENT WARS We asked 5 top AI models to design, engineer and 3D print a bridge to with the goal of holding the most possible weight. 🇺🇸 Anthropic: Claude Opus 5.5 (High) 🇨🇳 Kimi: Kimi K3 (High) 🇺🇸 Meta: Muse Spark 1.3 (High) 🇺🇸 OpenAI: GPT 6 Astra (High) 🇺🇸 SpaceXAI: Grok 4.7 (High) Each bridge had specific parameters. It had to span 2 feet, use a maximum 500 grams of filament, and it had to be under 18 hours of printing time. We specified what type of weight and where we would place it on the bridge. The Score: • Claude Opus 5.5 held an estimated 130 lbs! It took 9 hours and 11 minutes to print 17 parts and used 441 grams of filament. • Meta Muse Spark 1.3 held 26.5 lbs. It took 13 hours and 12 minutes to print 49 parts and used 478 grams of filament. • OpenAI GPT-6 Astra held an estimated 17.5 lbs. It took 15 hours and 44 minutes to print 29 parts and used 442 grams of filament. • SpaceXAI Grok 4.7 did not finish. On assembly it could not stand up by itself. It took 12 hours and 22 minutes to print 29 parts and used 460 grams of filament. • Kimi K3 did not finish. It wasn’t engineered correctly so the bridge could not even be assembled. It took 11 hours and 19 minutes to print 35 parts and used 446 grams of filament. That means our champion for this episode is Claude Opus 5.5. Not only did it hold the most weight (by FAR) it also took the least time to print, used the least amount of parts and used the least amount of filament. This was episode 02 of Agent Wars, stay tuned for episode 03.

A Flock of Altruists - Hit The Breaks Except For Me

NEW: Reed Jobs, a prominent biotech investor (and son of another Jobs you may have heard of), calls for a doubling of the NIH budget to $100 billion. Via @statnews statnews.com/2026/09/21/nih-…

In a new collaborative study publish in @ScienceMagazine today, researchers at 23andMe and @DanaFarber used data from more than 3.3 million 23andMe consenting research participants to characterize a rare inherited EGFR variant that significantly elevates lung cancer risk, while also exploring its relationship to smoking, polygenic risk, ancestry and geography. We found that the EGFR T790M genetic variant is carried by about 1 in 15,000 people in the United States, and is associated with a 25-fold increased risk of lung cancer. Among people who never smoked, carriers had a 60 fold higher odds of developing lung cancer than non-carriers. Illustration credit: @oliveruberti Learn more about the study and work here: 23andme.org/blog/articles/eg…

🆕💥🔴Phase III clinical trial evaluated Silevimig, a bispecific anti-rabies monoclonal antibody targeting antigenic sites I and III, as a substitute for human rabies immunoglobulin (HRIG) in post-exposure prophylaxis. Silevimig is safe and effective alternative for passive rabies post-exposure prophylaxis #idxposts academic.oup.com/cid/article…

Chipotle has gone all in on AI. It has an AI CV recruiting tool (“Ava Cado”) which reduces screening time by 75%. Also, an automated avocado-peeling and coring machine (“Autocado”) that reduces time to make batch of guacamole from 50 mins to 25 mins.

The FDA just approved a myostatin inhibitor for a rare muscle wasting disease to prevent muscle loss. Guaranteed this will be approved soon to be taken with GLP-1s. Myostatin inhibitors will be as big as GLP-1s.

A 25-year-old flew to Shanghai with lymphoma that had beaten everything New Zealand threw at it. He paid less than half of Australia's $600,000 quote. On August 18, his cancer was in complete remission. That's not a miracle story. It's a market forming. The wow isn't "China is cheap." It's this: cancer treatment is splitting into two industries. The old one sells protocols — chemo, radiation, off-the-shelf drugs. The new one sells design — a one-patient factory that re-engineers your immune system and ships it back into your vein. China just industrialized the second one. Patients are already buying the plane ticket. I'm a cardiologist. Here's the deep dive — the breakthrough, the business, and the part that should scare you. 🧵

Verified U.S. clinicians can get free GPT-6 Astra (Pro) access today via ChatGPT for Clinicians. Sign up: chatgpt.com/plans/clinicians…

Holy shit. Anthropic caught Iran using Claude to target Navy bases, automate dossiers on Americans, and run influence campaigns on US social media. Details are insane. The morons uploaded everything including the organization plans of the Ayatollah's funderal lmao

The Houthis will try and take control of Bab-el-Mandeb strait, when they take control, they will probably be additional players getting involved, this water way is strategic to Europe and Asia. Iran wants both chokepoints.

Video circulating on social media appears to show a U.S. Navy Saildrone unmanned surface vessel (USV) on fire, reportedly in the Strait of Hormuz earlier today. The Islamic Revolutionary Guard Corps (IRGC) has claimed that its forces targeted and destroyed the unmanned vessel near the entrance to the Strait. U.S. Central Command (CENTCOM) has not publicly confirmed the loss, and the circumstances surrounding the incident remain unclear. Saildrone USVs are designed for persistent maritime surveillance and can carry sensors supporting maritime domain awareness, undersea detection and ocean mapping. Their ability to operate autonomously for extended periods makes them particularly useful for monitoring chokepoints and other contested maritime environments.

This vial contains a new drug called PAC-3310. It was designed by ChatGPT, and I synthesized it in a chemistry lab I built in my garage. PAC-3310 is a new selective M4 muscarinic receptor agonist for treating schizophrenia - similar to the recent breakthrough drug Cobenfry, but improved. (1/7)