@smith__giri

Medical Oncologist & Hematologist | PhD candidate @uabsoph | interested in caring for older adults with cancer

 Hamden, CT
linkedin.com/in/smithgiri/
Joined December 2017
  • Tweets526
  • Following156
  • Followers440
4Media
Smit Giri MD MHS retweeted
Rohit
@heyrohitaiJul 16
🚨 Anthropic just showed a 27-minute workshop on how to actually do prompts for Claude. Taught by the people who built it. Free. No registration. No paywall. I've seen $300 courses that don't cover what they teach in the first 8 minutes. Watch the session
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Underutilization of guideline‐rec supportive care among older adults w/ myeloma in US [Aug 5, 2019] @smith__giri et al @JournalCancer ow.ly/s3Kb30pl8yw #mmsm #SuppOnc #IDonc #geriheme #cancerdisparities lower odds of influenza vaccination in 1st yr of Dx if Black & Medicaid

Underutilization of guideline‐recommended supportive care among older adults with multiple myeloma...

Among 1996 older adults in the United States who were receiving multiple myeloma–directed therapy, fewer than two-thirds received bone-modifying drugs within the first year of their diagnosis, and...

acsjournals.onlinelibrary.wiley.com
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Geriatric assessment-identified impairments and frailty in adults with cancer younger than 65: An opportunity to optimize oncology care geriatriconcology.net/articl… @mpergolottiPhD @smith__giri @GrantWilliamsMD @WilliamDale_MD @rochgerionc @myCARG #GeriOnc #OlderAdults #OncoAlert
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Racial differences in body composition and survival among older adults with gastrointestinal malignancies geriatriconcology.net/articl… @MFowlerPhD @smith__giri @GrantWilliamsMD @WilliamDale_MD @rochgerionc @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #RacialDisparities
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T cell exhaustion markers in multiple myeloma patients before and after physical activity intervention - Joseph et al. #ASCO23 Abstract 8060 meetings.asco.org/abstracts-… #mmsm #ImmunoOnc HT @rahulbanerjeeMD
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Smit Giri MD MHS retweeted
Pavlos Msaouel@PavlosMsaouel28 Jan 2024
Replying to @SuyogCancer @ASCO @OncoAlert @DrChoueiri @tompowles1 @montypal @dr_yakupergun @DrYukselUrun
To help find the answer the question will need to be properly reframed: why did pembrolizumab show a signal of efficacy whereas nivolumab was inconclusive? See section 10 “Comparative and Group-specific inferences” here for the tools needed 👇
Pavlos Msaouel@PavlosMsaouel23 Sep 2023
1/4 Just published our review on how to interpret RCTs focusing on key concepts such as sampling & allocation, uncertainty & variability, relevance & robustness, intention to treat & per protocol, potential outcomes & counterfactuals 👉 mdpi.com/2072-6694/15/19/467…
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Smit Giri MD MHS retweeted
NonsparseOncologist@5_utr28 Jan 2024
💯 Real world evidence is marketing terminology for the old “observational evidence” and implies that somehow RCTs don’t happen in the “real world”. Complete BS
Frank Harrell
@f2harrell28 Jan 2024
Replying to @RWJE_BA @elmir1omerovic @yudapearl @GreggWStone @xyu_shi @GiulioGrossi @kaulcsmc @stephensenn @drjohnm @VPrasadMDMPH
RWE is a truly bullshit term. The real world simply does not provide evidence about what would have happened to a patient had they received a different treatment from the one they received, except in cases (that are almost nonexistent) where treatment choices are dictated.
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Effect of home-based resistance training on chemotherapy relative dose intensity and tolerability in colon #cancer: The FORCE randomized control trial. acsjournals.onlinelibrary.wi… @ACS_Research @JournalCancer @DanaFarber #ExerciseOncology #CancerResearch #SuppOnc
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Smit Giri MD MHS retweeted
Pavlos Msaouel@PavlosMsaouel15 Jan 2024
Further discussion on this topic in the #DataMethods forum here: discourse.datamethods.org/t/… @f2harrell @Lester_Domes

Random vs. fixed effects meta-analysis

Extremely helpful again. My informal take on the Ivermectin literature, having been one of the lead statisticians on two Ivermectin RCTs, is that Ivermectin has a beneficial effect that happens to be...

discourse.datamethods.org
Triad sou.@triadsou15 Jan 2024
Appropriateness of conducting and reporting random‐effects meta‐analysis in oncology. Jinma Ren, Jia Ma, Joseph C. Cappelleri. Research Synthesis Methods. onlinelibrary.wiley.com/doi/…

Appropriateness of conducting and reporting random‐effects meta‐analysis in oncology

A random-effects model is often applied in meta-analysis when considerable heterogeneity among studies is observed due to the differences in patient characteristics, timeframe, treatment regimens,...

onlinelibrary.wiley.com
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Smit Giri MD MHS retweeted
Pavlos Msaouel@PavlosMsaouel12 Jan 2024
👇Thoroughly enjoyed this outstanding paper @IanMarschner. Perhaps a useful interpretation of Conf(BENEFIT)=0.94 is that the region of θ values corresponding to BENEFIT has 4 or less bits of information against it as per @Lester_Domes & @dailyzad 👉 bmcmedresmethodol.biomedcent…

Semantic and cognitive tools to aid statistical science: replace confidence and significance by...

BMC Medical Research Methodology - Researchers often misinterpret and misrepresent statistical outputs. This abuse has led to a large literature on modification or replacement of testing thresholds...

link.springer.com
Ian Marschner@IanMarschner11 Jan 2024
Confidence distributions are distributional summaries of evidence. They’re like Bayesian posteriors but without prior distribution assumptions. I wrote a tutorial paper in Statistics in Medicine for clinical trial statisticians @austrim_cre @TrialsCentre onlinelibrary.wiley.com/doi/…

Confidence distributions for treatment effects in clinical trials: Posteriors without priors

An attractive feature of using a Bayesian analysis for a clinical trial is that knowledge and uncertainty about the treatment effect is summarized in a posterior probability distribution. Researche...

onlinelibrary.wiley.com
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Personal reflection: "Clinical prediction models & the multiverse of madness" Thanks to @BMCMedicine for 'getting this' Many reviewers/Eds pushed for writing style & tone changes This thread delves into this & why we stuck to our original vision 1/n bmcmedicine.biomedcentral.co…

Clinical prediction models and the multiverse of madness

BMC Medicine - Each year, thousands of clinical prediction models are developed to make predictions (e.g. estimated risk) to inform individual diagnosis and prognosis in healthcare. However, most...

link.springer.com
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A short 1984 chapter by Richard Peto on "The need for ignorance in cancer research" republished today doi.org/10.1007/s10654-023-0…… foreshadows much of the progress & stagnation in cancer research over the past 40 yrs; a virtuoso piece, with a commentary here link.springer.com/article/10…
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Smit Giri MD MHS retweeted
Pavlos Msaouel@PavlosMsaouel20 Dec 2023
Pleased to share our latest article on why and how drug dose-finding can be tailored to each patient’s risk-benefit trade-offs 👉 journals.sagepub.com/doi/10.…
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Smit Giri MD MHS retweeted
Andrew Yee, MD
@andrew0211415 Nov 2023
Replying to @awechalekar @ash2023
Here's a link to the abstract referenced ash.confex.com/ash/2023/webp… Looking forward to seeing the presentation.
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This trial serves as an important reminder for the fact that ixazomib should have NO role in post-transplant maintenance in the current era! Adds GI toxicities without even a PFS benefit! #mmsm
Blood Journals Portfolio@BloodPortfolio8 Nov 2023
Postransplant maintenance with lenalidomide and dexamethasone resulted in a 6-year PFS of 61.3%, with no benefit of adding ixazomib. loom.ly/hYnTFYQ #clinicaltrialsandobservations #lymphoidneoplasia #multiplemyeloma #transplantation
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Smit Giri MD MHS retweeted
Cecilia Lund@cecilia_lund310 Nov 2023
Halv the older patients with gi cancers experience dizziness and walking impairments after chemotherapy, but it is underreported, as we never ask them! @KatrinePiper #SIOG2023 #gerionc
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Smit Giri MD MHS retweeted
Enrique Soto@EnriqueSoto824 Oct 2023
Hot off the press the new @ASCO @myESMO global curriculum recommendations for Cancer Care in Older Adults #gerionc Every oncologist should have key competencies in geriatric care! We hope this gets integrated in programs globally @HansWildiers @SIOGorg ascopubs.org/doi/full/10.120…
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In a couple of years we will talk about risk factor studies -- putting in a bunch of covariates in a multivariable regression model and declare the significant factors as important "risk factors" for health -- as one of the biggest mistakes in health research
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Smit Giri MD MHS retweeted
Mohamad Mohty
@Mohty_EBMT19 Oct 2023
1/⚠️Important need to knowℹ️ for using BCMA-directed agents in #MultipleMyeloma @NoopurRajeMD and myself have u covered 👇#MedTweetorial🧵gets u what u need 🏆🆓#CME 👉🏼 bit.ly/RRMM-TW5-CME Supported by edu grants from @JanssenUS & @Pfizer 📍What’s your specialty?
76%Hem/Onc MD/DO
4%MedOnc MD/DO
7%Other MD/DO
13%APP, RN, PharmD, OtherHCP
110 votes • Final results
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