Hey @bryan_johnson, the Rejuvenation Olympics is raising awareness of longevity, yes, but there is much progress to be made before we can call it trustworthy. I've seen numerous red flags with the RO leaderboard as of late - One month ago when @WSJ was interviewing me and others for this story, 9 of top 10 on RO were suddenly removed from the list; the 1 who remained was you. Somehow you went from #7 to #3. The ruleset has changed multiple times without explanation or transparency. Participants were dismayed. If you really want this to be a legit and fair competition as you claim it is, you should not be making the rules and overseeing it – you have a blatant conflict of interest. Instead, an independent body of scientists with no conflicts of interest should be – that's what the community deserves. I'd be happy to work with you on revamping the RO in the vein of transparency, and to reach out to respected Omics scientists and make that happen if you're willing to hand over the reins to them. I think it's great that you're bringing awareness to the field and I believe that you have the right intentions. Think of the public benefit something like the RO could have when we really can trust in it.

Muscle loss alone doesn’t fully explain why metabolism slows as we age. Using indirect calorimetry and DEXA scans across adults aged 20 to 80+, researchers found resting energy expenditure declines by roughly 63 calories per day per decade, even after adjusting for lean muscle mass, fat mass, and body size. That’s a cellular and mitochondrial shift, not just a loss of muscle volume. And it means preserving metabolic health span requires addressing mitochondrial function, physical activity, sleep, and hormonal signaling alongside progressive resistance training. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Longevity claims mean little without double-blind, placebo-controlled human evidence. In a six-month university-led trial, Novos Core demonstrated statistically significant support for arterial flexibility, vascular responsiveness, and healthy blood pressure maintenance—outperforming magnitudes typically reported for exercise, diet, or nitrate supplements. That’s an organ-level clinical outcome, not an indirect biological estimate. And it means nutritional support can measurably optimize vascular biology and system-level function to support long-term healthspan trajectories. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Standard lipid panels often miss critical cardiovascular risk. While traditional testing focuses on total cholesterol and LDL-C, measuring ApoB particle concentration and Lp(a) provides a far more precise assessment of atherogenic burden. That’s a direct particle concentration metric, not a basic lipid estimate. And it means incorporating advanced lipid biomarkers like ApoB and Lp(a) gives a clearer, actionable picture of long-term cardiovascular healthspan. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Most peptides marketed for anti-aging aren't longevity interventions - they're experimental appearance or performance compounds. GLP-1s have rigorous clinical evidence for specific populations. Many gray market peptides push growth hormone, IGF-1, or immune signaling pathways with little to no human data behind them. That's a pathway-based caution, not a blanket anti-peptide claim. And it means feeling or looking younger is not the same as aging slower. Demand human data before stacking any compound - no matter what a clinic calls it. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments - I'll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Aging gracefully is one thing. Aging well is another. How you age - not just that you age - determines your capacity to live independently, stay active, and experience life on your own terms. That's a healthspan outcome, not just an aesthetic one. And it means the latest science on aging isn't just for researchers. It's information everyone deserves access to, translated into approaches they can actually use. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments - I'll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Your afternoon energy crash isn’t just a lack of caffeine. High-glycemic meals trigger sharp glucose and insulin spikes, exacerbating the natural circadian dip and leading to reactive hypoglycemia later in the day. That’s a metabolic signaling issue, not a stimulant deficiency. And it means stabilizing blood sugar through lower-glycemic meals, protecting sleep quality, and using post-meal movement will effectively sustain daily energy. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Most fitness supplements aren’t designed for long-term longevity. While typical pre-workouts and fat burners rely on high stimulation for acute performance, true healthspan interventions target mitochondrial function, NAD metabolism, and vascular health. That’s a cellular mechanism, not a short-term sensation. And it means evaluating supplements based on biomarker impact and long-term biological safety rather than immediate physical perception. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Biological aging isn’t driven by a single pathway. Novos Core was engineered to address all 12 hallmarks of aging through a coordinated multi-pathway formulation supporting cellular repair, metabolic signaling, and mitochondrial health. That’s a multi-system biological approach, not a single-ingredient solution. And while cardiovascular function was the initial benchmark measured in human research, supporting vascular health serves as a foundational lever for whole-body longevity. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Standard exercise programs aren’t designed for lifelong healthspan. Focusing on VO2 max, muscle mass, and recovery builds physiological reserve, protecting cardiovascular fitness, glucose regulation, and overall mobility over decades. That’s a long-term structural adaptation, not a short-term aesthetic transformation. And it means sustainable longevity training requires balancing engine capacity and muscle preservation with joint health and recovery. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Frailty doesn’t happen overnight. Muscle loss quietly accelerates starting in your 30s, compromising metabolic regulation, insulin sensitivity, and physical reserve. That’s a metabolic and functional decline, not just an aesthetic change. And it means resistance training, progressive overload, and adequate protein intake are essential proactive levers to preserve strength, balance, and endurance. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

The Mediterranean diet isn’t effective because of a single ingredient. Epidemiological and clinical trial data show its benefits stem from a complete whole-food matrix rich in polyphenols, fiber, and unsaturated fats, alongside a reduced intake of ultra-processed foods. That’s a systemic dietary pattern, not a single-molecule intervention. And it remains the single strongest evidence-based nutritional framework for supporting cardiovascular, metabolic, and cognitive healthspan. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Navigating longevity shouldn't mean turning your life into a self-experiment. In placebo-controlled human research, Novos Core demonstrated statistically significant support for validated markers of cardiovascular function in midlife and beyond. That’s a human clinical outcome, not a theoretical supplement stack. And it means multi-year, university-validated R&D provides an evidence-based foundation so you don't have to rely on influencer trends or unverified protocols. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Aerobic fitness and strength training aren’t interchangeable. Cardiorespiratory markers like VO2 max strongly correlate with overall mortality risk, while muscle mass provides a critical buffer for glucose regulation and metabolic health. That’s a dual-system physiological requirement, not a preference for one discipline over the other. And epidemiological data consistently demonstrates that combining cardiovascular training with resistance exercise yields greater healthspan benefits than relying on either alone. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Looking fit isn’t a guarantee of biological health. Visual appearance often acts as a lagging indicator, while metrics like insulin sensitivity, vascular function, and chronic inflammation reflect true cellular age. That’s a physiological assessment, not an aesthetic evaluation. And it means optimizing long-term healthspan requires measuring internal biomarkers rather than relying solely on body composition or physical appearance. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Peptides aren’t just biological signals—they’re complex medical compounds. Many grey-market and compounded products lack regulatory oversight for purity, sterility, or precise dosing controls. That’s a real manufacturing and safety risk, not a minor bureaucratic detail. And while specific peptides show clinical promise, using unverified research chemicals without human trials or physician guidance is not evidence-based longevity medicine. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Vascular aging isn’t captured by cholesterol alone. Biomarkers like pulse wave velocity and flow-mediated dilation directly reflect arterial stiffness and endothelial function. That’s a structural and physiological metric, not just a lipid panel snapshot. And while consumer wearables offer useful trend tracking, clinical measurements remain the standard for evaluating vascular health. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Most brands pretend to be scientific just enough to get away with it. Real science is slow, expensive, and risky. Most experiments fail. We chose that path anyway. I've taken NOVOS every day for six years. So has my family — because I'd never give them something I wasn't personally confident in. That confidence comes from controlled human clinical research showing statistically significant support for cardiovascular function with effect sizes that outperform most published studies of commonly used supplements and lifestyle interventions. This is what we built. And it's why we keep going. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I'll cover them in future videos. #chrismirabile #novos #longevity #healthspan #aging #supplements #biohacking

Metabolic decline isn’t caused entirely by muscle loss. In a clinical study using indirect calorimetry and DEXA, age independently predicted lower resting metabolic rate even after accounting for lean body mass and fat mass. That’s a cellular and mitochondrial shift, not just a muscle mass problem. And it means preserving muscle is essential, but optimizing broader systems—like sleep, movement, and mitochondrial function—is required to address metabolic aging. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #Longevity #HealthOptimization #AgingScience #MetabolicHealth #CardiovascularHealth

Resveratrol gets all the attention — but its lesser-known cousin, pterostilbene, may be more interesting to scientists. Chemically similar but more bioavailable, pterostilbene shows up across preclinical research on oxidative stress, inflammation, mitochondrial function, and nitric oxide signaling. Most of the data is preclinical, so we shouldn’t overstate it. But when the same biological effects appear across multiple models, it’s worth paying attention to. Eat deeply colored berries. Protect your blood vessels. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I’ll cover them in future videos. #chrismirabile #novos #longevity #healthspan #aging #supplements #biohacking

Most people train for what they can see. But one of the most important things exercise does is invisible — it maintains your mitochondria. As we age, mitochondrial quality control declines. Damaged mitochondria accumulate, contributing to fatigue, inflammation, and metabolic dysfunction. Zone 2, HIIT, and resistance training each target different parts of that system. The best longevity plan isn't one-dimensional. Don't just train to look better. Train to keep your cells better maintained. Follow @slowmyage for more tips on optimizing your health! 💬 Drop your questions in the comments — I'll cover them in future videos. #chrismirabile #novos #longevity #healthspan #aging #fitness #zone2 #mitochondria #biohacking