The amazing group of people who support our research aimed at reversing aging in order to treat diseases and dramatically extend healthy lifespan
Boston, MA
Joined September 2025
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After a decade of work, it’s exciting to see the labs’ cellular reprogramming tech going into patients. Thank you to all the scientists who worked hard to make this possible and congrats to the entire @lifebiosciences team! 🚀
FDA greenlights Life Biosciences' human clinical trial on a "near total reset"
endpoints.news/exclusive-fda…
FriendsOfSinclairLab retweeted
Everyone’s excited about GLP-1s extending mouse lifespan. Does this mean patients might live longer?
The science explained, what this means for you, plus an interview with lead scientist Dr. Danica Chen📖
lifespan.com/blogs/magazine/…

FriendsOfSinclairLab retweeted
I’m incredibly proud & excited to finally share what we’ve been building for the past 3 years…
Lifespan.com is now live 🚀
In a world of conflicting health advice, how can anyone distinguish between what’s supported by science and what’s just opinion?
I wanted to build something new. A place where scientists, engineers, industry leaders, and the public come together, where people can understand what the science actually says, and where we move healthcare beyond treating sickness toward extending healthy lifespan well beyond what’s currently possible.
Explore the new Lifespan Magazine. Watch the Lifespan show. Ask scientists questions. Join a global community. And help support research and the next generation of scientists working to extend healthy human lifespan.
I believe we’re at the beginning of a revolution in our understanding of human aging, and perhaps one day, our ability to change it. I want everyone to be part of it.
Built by scientists. Built for you. Lifespan.com
Life’s too short. Let’s change that, together! 👊
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Note: The views of Lifespan & its team are their own & do not represent the views of Harvard, Harvard Medical School, or their affiliates✌️
FriendsOfSinclairLab retweeted
What if the future of healthcare isn’t just about treating disease, but reversing the aging process so our organs can cure themselves?
That future is beginning to take shape.
Today, Lifespan.com is live 🚀
It’s taken us 3 years to build a home for the science of living longer and healthier, bringing scientists, engineers, and the public together to separate evidence from hype, make cutting-edge research understandable to everyone, and make these new medicines a reality.
Explore the new Lifespan Magazine. Watch the Lifespan show. Ask scientists questions. Join a global community. And help support research and the next generation of scientists working to extend healthy human lifespan.
This is only the beginning!
Built by scientists. Built for you. Visit Lifespan.com
As we say at Lifespan: Life’s too short. Let’s change that, together!
——
Note: The views expressed by Lifespan & its team are their own and do not represent the views of Harvard University, Harvard Medical School, or their affiliates✌️ – at Boston, MA
FriendsOfSinclairLab retweeted
How can a tree live for 1,000 years?
Lifespan recently visited Shunkaen Bonsai Museum in Tokyo, where world-renowned master Kunio Kobayashi preserves trees that have been cared for by generations of bonsai masters
Their longevity may come from something trees do exceptionally well: renewal
A centuries-old bonsai is not made entirely of centuries-old tissue. Its leaves, roots, bark, and vascular tissues are repeatedly replaced. Plant stem cells, found in regions called meristems, continue producing new growth throughout life
Research on ancient trees suggests these stem-cell systems can remain active for centuries, supported by powerful repair and stress-response mechanisms
That may be relevant to human longevity. We also depend on stem cells to renew blood, skin, muscle, and other tissues. As we age, that regenerative capacity declines
Bonsai do not preserve every old part. They preserve the ability to renew. Perhaps this is due to epigenetic stability that preserves stem cell function – at Tokyo-to, Japan
So exciting to see our work in humans now! 🙏
New episode of Lifespan: Inside the World’s First Age Reversal Trial. New updates on how the trial is going & how to maximize vision!
youtu.be/VZDgTe5NDkQ?si=BeRf…
FriendsOfSinclairLab retweeted
Great to be back!
m.youtube.com/watch?v=rXLCug…
FriendsOfSinclairLab retweeted
Scientists stopped muscle aging in mice.
Blocking Hmgb1 in middle-aged mice with antibodies had remarkable results: senescent markers dropped, muscle regeneration improved, physical performance increased, and inflammation decreased.
FriendsOfSinclairLab retweeted
Congrats @lifebiosciences team. Big thanks to our investors. Well done Jerry McLaughlin, Michael Ringel, Amit Shashank, Sharon Rozenzweig-L, Ivan Kaplan, @Serenapoon & team. Go ER-100🤞
Not sure we qualify as “startup” after 8 yrs & being in the clinic 😉
endpoints.news/david-sinclai…
FriendsOfSinclairLab retweeted
Can’t wait for you to see the new episodes of Lifespan. Sign up & receive early access & bonus material. Launch April 2026 Lifespan.com ✌️
FriendsOfSinclairLab retweeted
Can’t wait for the first robot to present their findings at lab meeting
We built this demo in collaboration with a clinical pathology lab. It shows a single system doing real lab tasks: tool use, precision manipulation, and high level planning.
This was done in one take with no teleop and uses our skills based AI to enable generality while staying deterministic and reliable for real world workflows.
See more here: kyberlabs.ai/demos
👏 👏 👏
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG.
Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry.
In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward.
Michael also sits on the US board of @hevolution_f and on the board of the @AFARorg.
Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech!
0:00 Intro
2:30 Why aging is an optimization by evolution
15:10 Why scientists miss the role of evolution in aging
19:31 Evidence that aging is a regulated process
24:40 Hormesis and adaptive stress responses
28:55 The promise of partial epigenetic reprogramming in humans
35:08 Life Bio's first therapy proceeding to clinical trials
47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice
52:03 The pharma industry's perspective on anti-aging research
56:39 The importance of public engagement for funding and policy change
1:05:42 Reasons for optimism in longevity
1:08:26 Advice on how to have an impactful and interdisciplinary career
1:11:54 The ethical case for longevity
1:17:34 Concrete steps for audience members to support longevity research
FriendsOfSinclairLab retweeted
Oh wow — so cool to see two of my favorite examples that I’ve been using in my talks for close to a decade (rockfish lifespans spectrum from 10 to 200 years and the black garden ant queen’s 30-year lifespan vs. the worker’s 1-year [rather than a month — I think Michael misspoke]) getting wider airtime as evidence that aging is a programmed adaptation. The more people making this case, the better!
Here’s a video with relevant excerpts:
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG.
Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry.
In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward.
Michael also sits on the US board of @hevolution_f and on the board of the @AFARorg.
Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech!
0:00 Intro
2:30 Why aging is an optimization by evolution
15:10 Why scientists miss the role of evolution in aging
19:31 Evidence that aging is a regulated process
24:40 Hormesis and adaptive stress responses
28:55 The promise of partial epigenetic reprogramming in humans
35:08 Life Bio's first therapy proceeding to clinical trials
47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice
52:03 The pharma industry's perspective on anti-aging research
56:39 The importance of public engagement for funding and policy change
1:05:42 Reasons for optimism in longevity
1:08:26 Advice on how to have an impactful and interdisciplinary career
1:11:54 The ethical case for longevity
1:17:34 Concrete steps for audience members to support longevity research
FriendsOfSinclairLab retweeted
Every week, I tell one of my students to increase the font size on their slides, especially numbers. Here’s how you know you’re good:
Take 5 steps back from your laptop or monitor. If you can still read every letter & number clearly, you’re probably good 👍
Be discerning about companies whose mailing address is the someone's home and the office is in a mall
FriendsOfSinclairLab retweeted
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility
In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁
New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet
Why's that important? 🧵
