@simakali1

#BreastCancer #ProstateCancer #Hormones #TherapyResistance, targeting transcription in cancer. @simak.bsky.social 🔗https://nitter.cf/t.co/KLEBuEuDQa

 Imperial College London
imperial.ac.uk/department-surgery-cancer/research/cancer/groups/breast-cancer/
Joined November 2015
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🚨This short film exposes the true story of Israel's creation, entirely through the words of its own founders For decades, Israel’s lies have been carefully designed to demonize its victims. To ensure that no matter the crimes it commits, the children it slaughters, the world remains incapable of empathy for Palestinians, or at best, treats it with the same apathy that has allowed this to go on for as long as it has On the 78th anniversary of its creation, it's time the world knew that Israel's past is not different from the brutal present the world is finally seeing

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Can specific gene mutations drive CDK7 inhibitor resistance in #ProstateCancer? A brilliant team led by @simakali1 @imperialcollege share exciting new findings in @embojournal. Grab a ☕ and read: doi.org/10.1038/s44318-025-0…
Scientific Paper Published in The EMBO Journal, titled: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells. Written by Lai et al.

ALT Scientific Paper Published in The EMBO Journal, titled: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells. Written by Lai et al.

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Great way to finish the GRC Hormone-Dependent Cancers Conference by seeing our collaboration with the Wilbert Zwart lab published in PNAS. Glad to have contributed to this work. Read the paper here: pnas.org/doi/10.1073/pnas.25…

TRIM24 as a therapeutic target in endocrine treatment–resistant breast cancer | PNAS

While Estrogen receptor alpha (ERα)+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since ERα is still...

pnas.org
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So is the implication of this item that reviewers are uploading manuscripts into LLM? Does uploading manuscripts to LLMs by reviewers break confidentiality of the peer-review process? Scientists hide messages in papers to game AI peer review nature.com/articles/d41586-0…

Scientists hide messages in papers to game AI peer review

Nature - Some studies containing instructions in white text or small font — visible only to machines — will be withdrawn from preprint servers.

nature.com
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Calling all friends in the North and fellow Yorkshirepersons: Join me at Kemps bookshop in Weatherby on the 24th. when I’ll be talking to design guru David Swann about Superveloce and much more lnkd.in/eYgbc4ar

LinkedIn

This link will take you to a page that’s not on LinkedIn

lnkd.in
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I read this Cell paper that argues to have discovered a molecule (betaine) that mimics the geroprotective effects of exercise. This is a very valuable multi-omics resource, but the authors seemed to get caught in the rabbit hole of chasing a high-impact narrative🧵
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Where were the editors for this book? Where was the proofreading by the publisher? The publisher is clearly also at fault here.
Retraction Watch@RetractionWatch
28 Jun 2025
University “to investigate how AI text was part of book written by senior academic.” irishexaminer.com/news/arid-…
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So enjoyed your last two books on the British car. Looking forward to reading the italian story.
Peter Grimsdale@petergrimsdale
28 May 2025
The Times likes the cover. A big thank you to @timlayzellart for making his image available. One week to go...
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I am delighted to share our new paper published in Molecular Cancer! molecular-cancer.biomedcentr… As always, the credit goes to my great team and to all our collaborators! Interested in joining our lab: glare.bio/ #breastcancer #Immunotherapy #exosomes @SussexUni

LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte...

Molecular Cancer - Lemur Tail Kinase 3 (LMTK3) promotes cell proliferation, invasiveness and therapy resistance, and its expression correlates with poor survival in several different malignancies,...

link.springer.com
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If we want real progress we must protect those who speak out, not single them out goodlawproject.org/andy-geor…

Andy George called out police racism – so the police investigated him | Good Law Project

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The danger for the government is that it fails to control the things voters worry about - small boats and asylum hotels - while curbing the types of immigration that are popular and beneficial like scientists and care workers - my piece for @ObserverUK observer.co.uk/news/politics…

The UK is paying the price for world’s most expensive visas

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

observer.co.uk
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We describe how to perform Oligo-seq, a new method to map DNA motifs targeted by base editors. Validated with APOBEC3A and APOBEC3B, but adaptable to AID, CRISPR-Cas9, and more. 🧬 Full protocol 👉 sciencedirect.com/science/ar… Thanks to @RemiBuisson @AmbrocioSanchz at @UCIrvine!
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“Israeli forces have now dropped more explosives in Gaza than fell on London, Dresden, and Hamburg combined during the Second World War” says @NewYorker
The New Yorker
@NewYorker
18 Apr 2025
Clayton Dalton asked paramedics in Gaza what was hardest about their work. Responding to an airstrike and discovering that it’s your own family, one said. Recovering the bodies of children, said another. newyorkermag.visitlink.me/87…
A quote from a paramedic in Gaza: “It is strange that the world has allowed this to happen to us.”

ALT A quote from a paramedic in Gaza: “It is strange that the world has allowed this to happen to us.”

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Simak Ali retweeted
Tora Lab@LaszloTora
21 Mar 2025
Read our collaborative paper @longchrom, @molina_lab showing that disruption of NuA4 and ATAC coactivator complexes cause gene-specific transcript buffering, suggesting that cells dynamically adjust RNA export/degradation to sustain cellular homeostasis.10.1126/sciadv.adr1492
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(1/n) The first preprint from our lab is now out in @NatureGenet! We tried to tackle a key challenge in spatial biology to quantitatively characterizing cellular niches by learning spatial gene programs using NicheCompas led by @SebastianBirk_. Paper: shorturl.at/b4Hjk
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Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for many breast cancer scientists: biorxiv.org/content/10.1101/… @MCRCnews @MCRBreastCentre @LobularBCUK @FBMH_UoM

Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Gene expression is tightly controlled by DNA elements called enhancers by associating with lineage-specific transcription factors. These enhancers transcribe non-coding RNAs (called enhancer RNAs or...

biorxiv.org
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[1/2] Have a passion for cancer research? Want to understand how obesity drives lethal prostate cancer & grow your career at a world-leading University? 2x 3-year PhD studentships are available @imperialcollege, funded by @ProstateUK and PCF/ John Black Charitable Foundation.
Researcher looking down a microscope.

ALT Researcher looking down a microscope.

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The last 30 days has seen 2746 visitors to the Estrogene website (estrogeneii.web.app/). Please keep spreading this free and user-friendly resource for interrogation and visualization of estrogen and anti-estrogen action in breast cancer #BCSM
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Join the Virtual Cell Cycle Club virtual meeting on March 4, keynote Prof. David Pellman (Harvard) + short talks! 🔹 Free registration: events.abcam.com/cellcyclecl… 🔹 Abstract deadline: Feb 14 (talks), Feb 21 (breakouts) www-eur.cvent.com/c/abstract… #CellCycle #Science #CCCMeeting
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