@sidichen

Gene editing. Technology. Cancer. Immunology. Cell and gene therapy. Antibody. mRNA vaccine. @ Yale Genetics & Systems Biology. ## CRISPR in vivo ##

 New Haven, CT
sidichenlab.org
Joined December 2010
  • Tweets53
  • Following246
  • Followers1.1K
3Media
Excited to share our new Nature paper on in vivo CAR-NK CRISPRa screen + discovery of a hyperbooster for solid tumor nature.com/articles/s41586-0… Tx to Luojia, Paul, Drs Peng, Gunel, Moliterno, J Chen. #NK cell therapy @Yalegenetics @yalewestcampus @yalemed @yalecancer @yneurosurgery

OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours

Nature - The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell...

nature.com
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Proud to share our new work at Nature biomedical engineering on mRNA vaccine platform innovation! nature.com/articles/s41551-0… @Carolina Lucas @zane_zhenhao Fang @Yale @YaleGenetics @YaleWestCampus
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Proud to present our work at #KCRS25 on CAR-T screens, cell therapy and kidney cancer from @YaleMed @YaleGenetics @YaleWestCampus @YaleCancer Honored to be in session with Drs. Chuck Drake at JnJ, Nadal Rios at Hutch & Patrick Ott at Farber, hosted by David Braun &Hans Hammers.
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Sidi Chen retweeted
KidneyCAN
@kidneycan18 Jul 2025
#KCRS25 Session 6 highlighted how researchers are pushing the boundaries of what immunotherapy can do for kidney cancer patients. Engaging Native Immunity with ENPP3 with Chuck Drake TCR-Engineered Cell Therapy with @RosaNadalrios Next Generation T-Cell Engineering with @sidichen Future of Cancer Vaccines with Patrick Ott #AcceleratingCures
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🎉 CRI is proud to announce the 2025 CLIP and Technology Impact Award projects, a new class of high‑potential studies and tools designed to push cancer immunotherapy further and faster! Explore: bit.ly/4lzfuZi #Immunotherapy #CancerResearch #CancerResearcher
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Organizing an AI symposium on 6/20 with SAPA-CT at Yale. Please check it out and all are welcome to register/attend! @YaleWestCampus
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Excited to present our new work on multiplex immune gene therapies for cancer @ASGCT 2025 @NOLA @YaleMed @YaleCancer @YaleGenetics @YaleWestCampus
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.@sidichen co-chairs a symposium highlighting the transformative field of adoptive cell therapies for #cancer treatment #AACR25 with Dr. Daniel Powell @PennMedicine @AACR @SmilowCancer @YaleWestCampus @YaleGenetics
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Our lab generated 4 new lines of Cas12a transgenic mice and demonstrated utility in immune engineering, tumor modeling, and genetic disease treatment. Around to share w the field & community! @YaleMed @YaleWest @YaleGenetics @YaleData Also @LabWinslow nature.com/articles/s41551-0…

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering

Nature Biomedical Engineering - Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome...

nature.com
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Our new “MUCIG” therapy @FF Zhang ⁦@ScienceChow⁩ @GW ⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy | Nature Biotechnology nature.com/articles/s41587-0…
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Our team’s new work “MUCIG” cancer therapy - Multi-target approach counters tumor growth in several cancers | Yale News @Feifei Zhang ⁦@ScienceChow⁩ @Guangchuan Wang ⁦@Yale⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ news.yale.edu/2025/01/16/mul…

Multi-target approach counters tumor growth in several cancers

Yale scientists have developed a treatment approach that simultaneously targets multiple immune-suppressing genes and inhibits growth in four types of cancer.

news.yale.edu
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Honored to serve on the panel of #AI for drug discovery in biomedicine at #AIME 2024 Utah. Very stimulating discussions on future of medicine, challenges etc, with experts and audience. @YaleData @yaledatascience @YaleGenetics @YaleCancer @Yale_Ventures
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Our first in vivo primary NK screen that discovered new NK cellular checkpoints. Kudos for team for their 5 years of work. nature.com/articles/s41587-0… @YaleGenetics @YaleMed @YaleWestCampus @YaleCancer @YaleData

In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints...

Nature Biotechnology - The antitumor efficacy of chimeric antigen receptor natural killer cells is enhanced by genetic engineering.

nature.com
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“Building a community and paying attention to that community is the essence of getting things done.” Today #JameelClinic Advisory Board Chair and Nobel laureate Phil Sharp celebrated the 50th anniversary of his lab, “The Sharpies” — half a century of sharp minds!
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Our new high fidelity enhanced AsCas12a/Cpf1 transgenic mice after five years of work. Generated by Matt Dong and colleagues here in lab at @YaleGenetics @YaleCancer @YaleMed @YaleWestCampus Anyone who want to try them out feel free to please contact us. biorxiv.org/content/10.1101/…

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease...

The advancement of CRISPR gene editing technology, especially the development of Cas9 knock-in mice, has significantly boosted the functional discovery of various genetics factors in diverse fields...

biorxiv.org
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Our new piece of tools for gene delivery and cell therapy.nature.com/articles/s41551-0… westcampus.yale.edu/news/yal… @YaleGenetics @YaleMed @YaleWestCampus @YaleData @YaleCancer

AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the...

Nature Biomedical Engineering - A gene-delivery system relying on a Sleeping Beauty transposase encoded into an mRNA delivered by an adeno-associated virus enhances the stability and efficiency of...

nature.com
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Got the cover for this one as well at Nature Biomedical Engineering :)
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Congrats for Ariel Xiaoyu Zhou my postdoc in @YaleCancer @YaleGenetics @YaleMed @YaleWestCampus @YaleData getting an NIH/NCI K99/R00 award starting this month to study T cells and engineer next generation CAR-T cell therapy for cancer!
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🤩🤩 Beautiful cover art @NatureBiotech depicting new paper led by Xiaoyun Dai @sidichen lab 👇🏽👇🏿👇
Nature Biotechnology
@NatureBiotech13 Sep 2023
The September issue is live nature.com/nbt/volumes/41/is… On the cover, Dai et al. screen a large pool of differentially mutated CAR-T cells for genetic perturbations that enhance function go.nature.com/3WPqyEM
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We are thrilled to announce the official launch of Genome Editing in Cancer and Immunology, a specialty section journal led by Prof. @sidichen of @YaleMed. Ready to receive your submissions. Discover more here: fro.ntiers.in/GECancerandImm…
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Our work at Nature Immunology on a new way of cell therapy engineering. Proud of 1st author Ariel & team. Special Tx to Dr. Levchenko. @Yale @YaleGenetics @YaleCancer @YaleWestCampus @YaleData @YaleMed nature.com/articles/s41590-0…
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