@shivanibr

Professor & Director of Research. Studies #orofacialpain, #cancerpain,#oralcancer . Love #travel ( blog at https://xitter.cf/t.co/bqu3Gk64sj), #tennis and singing.

 @UTHealthSA, San Antonio, Tx
uthscsa.edu/academics/dental/profile/ruparels
Joined February 2009
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New research highlights a key sex difference in pain resolution: in males, androgen signaling promotes IL-10+ monocytes that "switch off" pain after inflammation. Congrats to the Laumet Lab team on this fantastic paper! @geoffroylaumet buff.ly/61wyU5C

Monocyte-derived IL-10 drives sex differences in pain duration

Peripheral monocytes and IL-10 are associated with shorter pain duration in males in both mice and humans.

science.org
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Shivani Ruparel retweeted
Pain Research Forum@PainResForumMar 4
How do you think scientists could solve the primary limitation in neuroscience, according to @SuthanaLab – a lack of cross-species dialogue? bit.ly/4qSs6gd #PRF @_TheTransmitter, Illustration by mariacorte.com
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Maybe in my 40s I can say the paper was accepted 🙈
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Science News@SciencNewsJan 2
How to write an introduction section of a scientific article?
Science News@SciencNews31 Dec 2025
Tips on How to Write ‘Good’
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Shivani Ruparel retweeted
NIH
@NIHJan 2
NIH's National Institute on Aging is seeking proposals for compounds to be tested through the Interventions Testing Program (ITP), which measures the ability to extend lifespan and/or delay the onset of diseases. Applications due Feb. 27, 2026. Learn more ➡️ nia.nih.gov/research/dab/int…
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A detailed Script of one of my most elite trips in the US #lovetravel #lovenature #alaska #glaciers #wildlife #summervacations mytripscripts.com/2025/12/29…

A Dreamy Alaskan Summer: An Exquisite Trip through America’s Wildest Landscapes

Alaska had been on my travel wish list for a long time, and when we finally visited during the peak of summer, it turned out to be everything we imagined and more. From snow-capped mountains and ma…

mytripscripts.com
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Center for Pain Therapeutics and Addiction Research. @UTHealthSA is searching for our next tenure-track faculty recruit. Outstanding Enviornment and colleagues. Please apply or share widely. #neuroscience #painresearch #addictionresearch #orofacialpain uthscsa.referrals.selectmind…

CPTAR - Open Rank (Assistant/Associate/Professor) in San Antonio

The University of Texas Health Science Center San Antonio, School Dentistry, is seeking applications for a full-time position of a tenure...

uthscsa.referrals.selectminds.com
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Are you interested in the psychobiological pathways of healing? Register now for this webinar from @Colloca_Lab featuring Karin Meissner bit.ly/43ebAxY #PRF #webinar
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I was extremely lucky to receive two RO1s in the current climate literally just before the fiscal year end and government shutdown🙏 I so wish this was the story of all academic scientists in the US. #savescience news.uthscsa.edu/school-of-d…

School of Dentistry at UT Health San Antonio awarded $6 million total to study treatment, pain...

Three multi-year NIH grants target painful disease with low survival rate Contact: Steven Lee, (210) 450-3823, [email protected] SAN ANTONIO, Nov. 7, 2025 – Researchers at the School of Dentistry at...

news.uthscsa.edu
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Intrathecal administration of the Nav1.7 inhibitor... : PAIN journals.lww.com/pain/abstra… Interesting—this might work, but sympathetic side effects? Long-term use may be impractical. At 30 nM, what’s the exposure? Good to see opioid dependency here, though the controversy continues.

PAIN

Explore PAIN, featuring peer‑reviewed articles, clinical studies, and the latest medical research.

ovid.com
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Our take on the future of pain science in @PAINthejournal Innovating pain research: bridging gaps and shaping the... : PAIN journals.lww.com/pain/abstra…

PAIN

Explore PAIN, featuring peer‑reviewed articles, clinical studies, and the latest medical research.

ovid.com
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Have you ever wondered what it is like to speak with a faculty member at @NAPainSchool? Check out this interview between Daniela Maria Escobar Espinal and Kirsty Bannister today! bit.ly/4gO5TMF #PRF #ScienceCommunicators
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Shivani Ruparel retweeted
Rebecca Seal@lab_seal7 Oct 2025
New episode of The Pain Beat just dropped! A key route to identify new pain treatments is gaining traction. Hear more about it at the Pain Research Form. painresearchforum.org/multim… @PainResForum @IASPpain @psalmotoxin @SutherlandPhD
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ICYMI: Good news! The House rejected the proposed 40% NIH funding cut. The bill released has NIH funded at $48 billion, almost identical to the Senate’s number of $48.7 billion.
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Shivani Ruparel retweeted
Mark Zylka
@MarkZylka28 Aug 2025
Single cell seq studies typically use a single mouse strain. To determine how genetic diversity affects brain cell composition, we performed snRNA-seq on 14 different mouse strains. Found that components of neurovascular unit-pericytes and endothelial cells-show greatest variation across strains. journals.plos.org/plosone/ar…

Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains...

Genetic background influences animal behavior and susceptibility to brain diseases. To evaluate how genetic background influences the relative number and/or types of cells in the brain, we performed...

journals.plos.org
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Check it out! An interview on pain mechanisms and therapeutics with Dr. Clifford Woolf, PhD, MB, Bch of Harvard Medical School by Julia Nickols at the North American Pain School is now posted on PRF! painresearchforum.org @IASPpain @CanadianPain @NAPainSchool @AusPainSoc
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Just posted on Pain Research Forum! Dr. Allan Basbaum's curated list of pain-related papers published August 8-15, 2025 and his choices for Editor's pick. Posted at painresearchforum.org
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NIH
@NIH15 Aug 2025
New NIH research finds that chronic pain has surged 18% since before the COVID-19 pandemic, bringing the total to more than 60 million adults. The findings highlight an urgent need to address this growing public health crisis. bit.ly/4oDid6c
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Do you have questions about advancing outcome measurement development and translational relevance of animal models of #pain? Sign up for this in-person, 2-day workshop in Bethesda, Maryland, USA now bit.ly/460tjek #PRF
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Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine | PNAS pnas.org/doi/10.1073/pnas.25…

Modulation of human dorsal root ganglion neuron firing by the Nav1.8 inhibitor suzetrigine | PNAS

Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX...

pnas.org
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