UW Protein Engineer. Open Science initiate, two-wheeled fundi, cultural enthusiast, drummer and purveyor of rhythm.
Toronto, Ontario
Joined February 2012
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- Following1.5K
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It would seem that, like early attempts to #patent BRCA1 and 2 genes, an #epitope is - as #SCOTUS concluded, a "product of nature and not patent-eligible merely because it's been isolated" Patenting epitopes would chill #innovation and #competition
nature.com/articles/d41586-0…
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Shane Miersch retweeted
A new generation of engineered, tailored #antivenom for treating snake bites is developed using phage display to discover antibodies that neutralize snake toxins. Read more: sophion.com/publications/syn…
#antivenoms #venoms #ionchannels #qpatch #qube384
Shane Miersch retweeted
Our diabody paper was just published today! Thanks to @shanedontgo and Dev Sidhu for the beautiful and fruitful cooperation!
Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies cell.com/cell-reports/fullte…
New work from the #Sidhulab @UofT @TRACantibodies in intl collab w @unitorvergata @NovelliGnovelli @WUSTL @unibs_official showing that #bispecific #tetravalent #antibodies enhance #neutralization and breadth of #specificity against #SARSCoV2 variants
cell.com/cell-reports/fullte…
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Shane Miersch retweeted
Sviluppato un anticorpo monoclonale che si lega alla proteina Spike del virus SarsCoV2 con una potenza 100 volte superiore a quella degli altri anticorpi ora disponibili, neutralizzando molte varianti
@unitorvergata
@unibs_official
@UofWA
@UofT
@MIsocialTW
bit.ly/3t0HbRE
Shane Miersch retweeted
Thurs in #HighPark a motorist used his vehicle to assault & intimidate a cyclist. These common incidents lay bare the fallacy of the cyclist menace. High Park should be closed to motor vehicles @gordperks. Ticket/charge dangerous drivers @TorontoPolice not cyclists going 24km/h – at Toronto, Ontario
New pub showing that potent #toxin-neutralizing #antibodies can be obtained from naive #synthetic libraries. One step closer to recombinant, oligoclonal anti-venoms. Thanks to our collabs in the Tropical Pharmacology Lab at the Technical University of Denmark!
#syntheticbiology
New paper from @TropicalPharLab on synthetic human #antibodies against α-cobratoxin: onlinelibrary.wiley.com/doi/…
Thanks to great collaborators, @shanedontgo, @LLedsgaard, @UofT, @sophionbio, @DTUbioengineer, @DTUtweet, and funders @ERC_Research, @VILLUMscience @VILLUMFONDEN
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Shane Miersch retweeted
A slap in the face. These are the consequences of Cllr Farr's motion. How exactly does increased funding for enforcement even begin to solve houselessness? What could become possible if $400,000 was redirected to social supports? When Hamiltonians cannot afford market rent?
This quoted post is unavailable.
“I wouldn't be surprised if in 10 or 15 years, we can get to the point where [reversing hearing loss] would be similar to Lasik surgery"
news.mit.edu/2022/frequency-…
#regenerativemedicine
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Cyclist Daniel Bertini's killer was doing 125 kph in a 60 kph zone then fled on foot. That got him two years and a 5 yr driving suspension.
Can cyclists be any more expendable in the eyes of the law?
jnyyz.wordpress.com/2022/03/…
#vulnerableroadusers #cycling #murder
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A new agency chaired by #KarimaBawa intended to support #Ontario researchers and businesses in developing #intellectualproperty portfolios that will protect #innovation and bolster #commercialization while trying to keep #IP in Canada
#CIPO
ontario.ca/page/intellectual…
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Dr. Chris Garcia (#Stanford) talks about mechanisms of #cytokine signaling and how structural insights have helped to engineer specificity in to #synthetic #cytokines #QB3 xitter.cf/shanedontgo/status/149…
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Shane Miersch retweeted
@Why_Not_Bikes of @PBOTinfo has a great quote like this:
“Riding a bicycle should not require bravery. Yet, all too often, that is the perception among cyclists and non-cyclists alike.” portlandoregon.gov/transport…
Very proud to see my friend and former colleague - Wilson Endege, from my post-doctoral studies at HMS in Boston, bringing his vision to reality and building self-sufficiency in East Africa with #DaktariBiotechnology youtube.com/watch?v=fIREL5Mg…
Shane Miersch retweeted
As an editor, I can't tell you how many times I see cover letters where I just ... wonder?
The first impression is the most important one, and too many times - it's not the best impression.
How to write a compelling cover letter: a thread.
NB: These are my views and mine only!
"Protein structures are things of beauty, with their complex web of intricately positioned and interlocking elements that fold up precisely to generate a particular biological function" - Ian Wilson
youtube.com/watch?v=Nouv3LTp…
#protein #structures #Influenza
