@sevan_belian

PhD student at Institut Pasteur, working on the mecanism of formation of tunnel in nanotubes.

 Paris, France
Joined March 2023
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In this paper, we review the spread of neurodegenerative pathologies, with a special emphasis on tunneling nanotubes (TNTs).
Extracellular Vesicles & Circulating Nucleic Acids@VesiclesAcids9 Mar 2023
New review - Hijacking #intercellulartrafficking for the spread of protein aggregates in #neurodegenerative diseases: a focus on #tunneling #nanotubes (TNTs) from @_ranabir and Professor #ChiaraZurzolo of @univ_paris_cite @UnivParisSaclay @UninaIT evcna.com/article/view/5498
TNTs facilitate the transfer of NDs-causing protein aggregates. A: Unhealthy cells containing protein aggregates can form TNTs with a naïve, healthy cell, eventually spreading aggregates such as PrPSc (Prion’s disease), Tau and Amyloid-β (AD), α-Syn fibrils (PD), and mHtt (HD). B: Such transfers can happen between the same type of cells via homotypic TNTs (left panels), or between different cell types via heterotypic TNTs (right panels).

ALT TNTs facilitate the transfer of NDs-causing protein aggregates. A: Unhealthy cells containing protein aggregates can form TNTs with a naïve, healthy cell, eventually spreading aggregates such as PrPSc (Prion’s disease), Tau and Amyloid-β (AD), α-Syn fibrils (PD), and mHtt (HD). B: Such transfers can happen between the same type of cells via homotypic TNTs (left panels), or between different cell types via heterotypic TNTs (right panels).

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