@ser_rius

Biochemist. Assistant Professor. Department of Cellular and Fuctional Biology. Faculty of Biological Sciences. University of Valencia.

Joined January 2025
  • Tweets23
  • Following50
  • Followers23
3Media
Redox signaling in the pancreas in health and disease | Physiological Reviews journals.physiology.org/doi/…
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Sergio Rius retweeted
Ruben QC@RubenQC_LabSep 16
It is out! 🎉 Proud to contribute to this team effort by referents in the ROS field. Beyond advancing our understanding of #mitochondria(l) #bioenergetics and #redox, we present a resource with clear workflows to guide research🔬👇 sciencedirect.com/science/ar…
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Sergio Rius retweeted
SEBBM
@SEBBM_esSep 10
Turno para Sergio Rius-Pérez @UV_EG presenta: “Ferroptosis In Pancreatic Disease: Redox Signalling, Inflammation And Mitochondrial Fitness” #48CongresoSEBBM #ReuniónRegulaciónMetabólicaYNutrición @universitatURV
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~Laura🫀~@lauradobuSep 10
El Dr.Sergio Rius-Pérez nos habla sobre “Ferroptosis In Pancreatic Disease: Redox Signalling, Inflammation And Mitochondrial Fitness”#48CongresoSEBBM Muy buena investigación, cargada de colaboraciones top y con unos resultados muy prometedores.
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Excited to share our new study! Uncovering the distinct roles of NOX1 and NOX2 in acute pancreatitis and obesity DIVERGENT ROLES OF NOX1 AND NOX2 IN ACUTE PANCREATITIS AND DOWNREGULAT... sciencedirect.com/science/ar…
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Great collaboration with Dr. Jaime Font de Mora and the Clinical and Translational Research in Cancer group from @IISLaFe! Tumor-educated macrophages promote cytokine-driven lung colonization in triple-negative breast cancer tandfonline.com/doi/full/10.…

Tumor-educated macrophages promote cytokine-driven lung colonization in triple-negative breast...

Triple-negative breast cancer (TNBC) remains one of the most lethal breast cancer subtypes, driven by early dissemination and resistance to therapy. Here, we reveal a macrophage-centered cytokine c...

tandfonline.com
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Very proud of my PhD student Néstor Jiménez for his first research article! Obesity suppresses neutrophil-dependent itaconate signaling promoting ... sciencedirect.com/science/ar…
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New! Online now: Homocysitaconate controls inflammation through reshaping methionine metabolism and N-homocysteinylation dlvr.it/TMk106
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New! Online now: RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation dlvr.it/TLYTBr
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Itaconate modulates immune responses via inhibition of peroxiredoxin 5 go.nature.com/3RsJokJ

Itaconate modulates immune responses via inhibition of peroxiredoxin 5

Nature Metabolism - Itaconate is shown to non-covalently inhibit the antioxidant enzyme peroxiredoxin 5 in macrophages, thereby modulating the production of mitochondrial peroxide and enhancing the...

nature.com
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RESEARCH | AM Casey, MP Murphy et al. (U Cambridge): The study explores the basic mechanisms of superoxide production in #mitochondria and its impact on interleukin-1β production in LPS-treated macrophages 🧫✨ nature.com/articles/s42255-0…

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport...

Nature Metabolism - Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

nature.com
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Review in @physiolrev by @ser_rius & co-authors discusses #OxidativeStress and #redox signaling in the #pancreas under healthy physiological conditions as well as in acute #pancreatitis, chronic pancreatitis, #PancreaticCancer, and #diabetes. ow.ly/EphK50VmvUf
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#NatMetabPicks | In @CellCellPress led by JB Spinelli (@UMassChan) Rhodoquinone carries electrons in the mammalian electron transport chain. cell.com/cell/fulltext/S0092…

Rhodoquinone carries electrons in the mammalian electron transport chain

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors...

cell.com
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🔬Researchers Chadha, Khurana & Schmoller from @HelmholtzMunich explore the link between #CellSize & cell function in this innovative review. Discover more: ow.ly/NtzK50TN2mL
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Subcellular mitochondrial heterogeneity enables opposing metabolic demands: Trends in Endocrinology & Metabolism cell.com/trends/endocrinolog…

Subcellular mitochondrial heterogeneity enables opposing metabolic demands

Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions...

cell.com
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Join our research team at University of Barcelona! We are looking for candidates to apply for a PhD position focused on mitochondria, aging and metabolism. 💡 Requirements: Academic grade >8 📅Deadline: Feb 14th If you are interested, contact me by DM ub.edu/beques/3rcicle/PREDOC…
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nature
@Nature24 Jan 2025
The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences go.nature.com/3WyCUnb
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Another amazing piece of work from @ShivKSingh6 lab with @BarbaraGrnwald 😃 As always, crazy amount of data and provocative results!! Kudos to the team 👏👏. Honored to have contributed a small piece. Don't miss the thread and of course the paper!
Shiv K Singh & Lab@ShivKSingh66 Jan 2025
📢 Excited to share our study in @NatureComms, previously available on bioRxiv by Klein et al. 👉 rdcu.be/d5q9f
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Mitochondrial segmentation and function prediction in live-cell images with deep learning | Nature Communications nature.com/articles/s41467-0…

Mitochondrial segmentation and function prediction in live-cell images with deep learning

Nature Communications - MoDL, a deep learning algorithm, is developed to link mitochondrial morphology and function. Trained on extensive mitochondrial image and biochemical data, MoDL delivers...

nature.com
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Sergio Rius retweeted
Marc Beltrà@BeltraMarc4 Apr 2023
📰 Very proud of our work published in @NatureComms. We demonstrate that muscle and liver NAD+ depletion in cancer #cachexia can be reversed using the NAD+ precursor #niacin (vitamin B3), ameliorating muscle wasting and improving mitochondrial metabolism. nature.com/articles/s41467-0…

NAD+ repletion with niacin counteracts cancer cachexia

Nature Communications - The loss of nicotinamide adenine dinucleotide is reported to be associated with muscle mitochondrial dysfunction in murine cancer models. Here the authors show that niacin...

nature.com
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Sergio Rius retweeted
Eric Topol
@EricTopol14 Jan 2025
This has been needed for a long time! Redefining obesity A new report of @TheLancetEndo commission that overrides current BMI categories and better defines features and pathophysiologic consequences of pre-clinical and clinical obesity thelancet.com/journals/landi… open-access (such as an athlete with no fat excess is not obese, but is according to current BMI based definition)
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