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What are the relationships between childhood trauma, inflammation, metabolic health, and mental health in a community sample of adults?
Wallace et al., showed that:
#ChildhoodTrauma #MentalHealth #Inflammation #MetabolicHealth
@STAR_BrownDPHB, @BrownPsychiatry
Childhood trauma was associated w/ higher inflammation, which was linked to both mental health symptoms and poorer metabolic health
• Higher physical activity was associated with lower insulin resistance + fewer depressive symptoms
📖 Read the article:doi.org/10.1017/neu.2026.100…
🧠 Can neuropsychological tasks improve our understanding of depression and anxiety in adolescents?
A recent scoping review examined the use of three widely used paradigms:
• Emotional Go/No-Go (EGNG)
• Delay Discounting Task (DDT)
• Balloon Analogue Risk Task (BART)
Associations between task performance and symptoms of depression or anxiety were inconsistent
It highlights important gaps in the field and emphasizes the need for + longitudinal and intervention studies.
📖 Read the review: dub.sh/27zWac4
A 25-year longitudinal birth cohort study from Estonia reveals how genes, biomarkers, environment, and family shape behavior, mental health, and life trajectories. Findings offer key insights into neurodevelopment, psychiatric risk!
Some papers carry more than scientific weight: they carry legacy.
This study honors a deeply respected contributor to Acta Neuropsychiatrica and a leading figure in psychiatry, whose impact continues to shape the field.
Authors also explore the mechanistic basis of these effects, including receptor interactions.
The review points to a compelling possibility: that ibogaine’s therapeutic value may extend beyond symptom relief to supporting neural repair.
doi.org/10.1017/neu.2026.100…
How effective are music-based interventions for mental health in young adults?
In this systematic review of clin trials in young adults, found that music therapy, binaural beats & rhythm-based auditory stimulation are associated w/ moderate improvements across multiple domains:
– Anxiety and mood regulation
– Sleep quality
– Stress-related physiological markers
– Cognitive performance
Effect sizes indicate clinically meaningful, though not large effects.
These non-pharmacological, technology-delivered approaches offer accessible support and align with young adults' lifestyle.
A promising step toward scalable mental health support. Check the study for more info: doi.org/10.1017/neu.2026.100…
Acta Neuropsychiatrica retweeted
The latest perspective on ibogaine's potential to facilitate white matter repair in CNS injury @scnpjournal doi.org/10.1017/neu.2026.100… Published with icons Beni Lerer, Steve Shoptaw and the late Dan Stein, the kindest giant in (cape) town. RIP 😢
🧠🧬 Autoimmunity as an underexplored contributor to neuropsychiatric symptoms in 22q11.2 deletion syndrome
A recent study synthesizes evidence linking autoimmune processes to the neuropsychiatric phenotype observed in 22q11.2 deletion syndrome (22q11DS).
📄 Individuals with 22q11DS may develop
• increased circulating autoantibodies & elevated inflammatory markers
• increased BBB permeability
• Converging evidence shows that antibodies targeting neural proteins can induce psychiatric symptoms
🧩 Findings suggest
Autoantibodies may represent an under-recognized source of vulnerability, acting alongside the genetic deletion
🔬 This perspective opens new directions for research and clinical consideration, including immunological screening
doi.org/10.1017/neu.2025.100…
How prevalent are behavioural addictions among adolescents?
A newly published study in Acta Neuropsychiatrica suggests insights by examining multiple behavioral addictions simultaneously.
It identifies strong links to underlying mental health:
• Food addiction was tied to depression, anxiety, and stress.
• Problematic internet use was linked to depression and stress.
• Internet gaming disorder was associated with anxiety.
The high rate of problematic internet use reflects the digitally immersive world.
Findings underscore the deep connection between behavioral patterns and mental well-being.
doi.org/10.1017/neu.2026.100…











