Pluripotent stem cell scientist developing next-gen β islet therapies.
Boston, MA
Joined January 2015
- Tweets332
- Following314
- Followers278
- Likes1.7K
Leonardo Velazco-Cruz retweeted
🚨Preprint alert #1🚨AI-driven spatial transcriptomics for a SC-pancreas transplant test case - fantastic collaboration with @ganoopyliujia @wenbowang11 @ZuwanLin - checkout the youtube demo!
Thrilled to share our latest preprint regarding STAgent, a multimodal AI agent for spatial transcriptomics.:
(1/9) Check our manuscript at: biorxiv.org/content/10.1101/…
and demo at: youtu.be/aEUop05RINY
Leonardo Velazco-Cruz retweeted
Sana Biotechnology's first-in-human study of hypoimmune-engineered deceased donor islets shows insulin production & immune evasion without immunosuppression #Diabetes #T1D #CellTherapy ir.sana.com/news-releases/ne…
Leonardo Velazco-Cruz retweeted
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s42255-024-0…
A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.
Leonardo Velazco-Cruz retweeted
Online @Cell_Metabolism - a Focus on Humanislets.com. Views on data accessibility, sharing, quality, and general thoughts on the field.
“HumanIslets.com: Improving accessibility, integration, and usability of human research islet data”
authors.elsevier.com/a/1jsQ9…
Leonardo Velazco-Cruz retweeted
The classic hourglass structure of paper writing
#academicx #phdchat
ALT Two hourglass shapes for paper writing, one for the abstract and one for the full paper.
Leonardo Velazco-Cruz retweeted
🧬 Exciting new study out in @NatureComms! We identify cell-type-specific responses in pancreatic islets to stress, shedding light on diabetes progression. It is #OpenAccess for all to download for free! #DiabetesResearch @WUSTLmed @WUDeptMedicine nature.com/articles/s41467-0…
Leonardo Velazco-Cruz retweeted
Hey, that's me! :)
#FacultyFriday: For over eight years at WashU, Dr. Millman has spearheaded a groundbreaking research program centered on the utilization of stem cells to study and combat diabetes. Read more about his work at bit.ly/4b8M6Dv. @JeffreyRMillman
Leonardo Velazco-Cruz retweeted
Thrilled to announce we just got funded by @novonordiskfond Research Leader program!! We will explore the mechanisms behind islet cell maturation using human pluripotent stem cells. Recruiting PostDocs and PhD students really soon, get in touch ;) @STEMMProgram @helsinkiuni
Leonardo Velazco-Cruz retweeted
Congrats to Millman lab alumni @ericamarquez95 and her @American_Heart fellowship!
Congratulations to #WashUBME doctoral student Erica Marquez on receiving an @American_Heart fellowship! Marquez studies cardio-electrophysiology in the lab of @JonSilva_StL and will study ion channels in the heart with the fellowship. engineering.wustl.edu/news/2…
Leonardo Velazco-Cruz retweeted
Our most complex biologic system—immunity—is reviewed in 3 new @CellCellPress papers, open-access
Adaptive
cell.com/cell/fulltext/S0092…
Innate
cell.com/cell/fulltext/S0092…
New insights
cell.com/cell/fulltext/S0092… @RMedzhitov
Leonardo Velazco-Cruz retweeted
Endocrine-metabolic research at #WashUMed can be traced to the Nobel Prize-winning work of Drs. Carl and Gerty Cori. Among their trainees were Drs. William H. Daughaday and David M. Kipnis, who molded and led our division during the 1950s-1970s.
Read more: endocrinology.wustl.edu/abou…
ALT Drs. Carl and Gerty Cori
Leonardo Velazco-Cruz retweeted
We previously performed a study demonstrating AMX0035 improves in Wolfram Syndrome patient iPSC-derived islets with @FumihikoUrano. @amylyxpharma just announced interim clinical trial data with AMX0035 showing improved diabetes and vision! Congratulations! amylyx.com/news/amylyx-pharm…
Leonardo Velazco-Cruz retweeted
Great work from the lab and a thorough characterization of pig pancreas development and comparison to other species! Congrats to @Carina_K_YANG @HannahSpitzer1 and all authors for the highly collaborative project! See tweetorial from the boss below for more details on the work!
Thrilled to share our work “A multimodal cross-species comparison of pancreas development”.
doi.org/10.21203/rs.3.rs-415…
A tremendous collaborative effort led by @Carina_K_YANG & @HannahSpitzer1, and other members of @LickertHeiko @fabian_theis, Eckhard Wolf labs.
Leonardo Velazco-Cruz retweeted
🗺️ Scientists charted a high-resolution roadmap with scRNA-seq to investigate pathogenesis of wolfram syndrome #βcell failure, revealing two distinct cellular fates along pseudotime trajectory: maturation and stress branches.
#OpenAccess in @cddpress:
🔗 go.nature.com/3UKP24i
Leonardo Velazco-Cruz retweeted
New from @HuisingLab @ucdavis The physiological role of δ cells and SST is to provide tonic feedback inhibition that reduces the β cell glucose threshold and consequently lowers the glycaemic set point in vivo #islets #diabetes @NatMetabolism nature.com/articles/s42255-0…
Leonardo Velazco-Cruz retweeted
A thing I ❤️ about my job is I'm lab-active. Semester is done; winter project going! 60 F1 hybrids; 500 plates poured for some F2s…time for some genetics! This will be a multi-day 🧵, which might become cautionary, about chasing an interesting observation w/dubious impact 1/n
ALT A computer monitor showing a microscope image of larval worms; stacks of petri dishes in the foreground
ALT Stacks of petri dishes on a laboratory benchtop
Leonardo Velazco-Cruz retweeted
Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets | Science Advances science.org/doi/10.1126/scia…
Leonardo Velazco-Cruz retweeted
Drs. Z. Ian Hu at @MDAndersonNews and Eileen O’Reilly at @MSKCancerCenter highlight contemporary areas of research for pancreatic cancer, including poly(ADP-ribose) polymerase inhibitors, KRAS-targeted therapies, and #immunotherapies.
nature.com/articles/s41575-0…
Leonardo Velazco-Cruz retweeted
Dr. Leete provides an overview of pancreatic anatomy, and the importance of research focused on the pancreas in #type1diabetes, which ranges from histological breakthroughs to briefly discussing the challenges associated with characterizing the organ.
onlinelibrary.wiley.com/doi/…