
M5 @CleClinicLCM. CS '21 @michiganstateu. Interested in artificial intelligence, health tech, and entrepreneurship. Always a student.
Cleveland, OH
Joined December 2022
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Sameed Khan retweeted
I think AI will be a transformative technology like the internet by which I mean it will buy us another 2-3 decades of 2.5% GDP growth.
Sameed Khan retweeted
I have a new favorite editor/IDE: Zed. Open-source, blazing fast, built-in AI operability, easy to use. Heard that lots of developers are dropping Visual Studio Code for Zed. Has R and Quarto extensions. zed.dev
Sameed Khan retweeted
93 million CT scans were performed in the United States in 2023. About a third covered the abdomen and pelvis. The colon is in the picture on every one of them, and almost nobody was looking at it.
A model published in Annals of Oncology this spring reads the colon on the noncontrast CT that was ordered for something else. In 18,419 consecutive real-world scans, it ran at 86.6% sensitivity and 99.8% specificity, with a positive predictive value of 63.4%. Five cancers nobody had found. About 30 seconds a scan. Ten radiologists using it gained 20 points of sensitivity.
This is not a colon story. Next month it will be a different finding on a different scan, and the month after that another one. Each arrives as a paper, then a vendor, then a question for a radiology department that answered the same question last month for a different tool. Departments deciding tool by tool cannot keep up, and most have stopped trying.
Hospitals already have the structure for a stream of new capabilities that each need an evidence bar, local validation, a pathway before adoption, monitoring after, and a process for removal. It's called a formulary. New drugs arrive every month and no hospital relitigates whether to have a pharmacy. Radiology needs the same committee for algorithms. The platforms to plug them in already exist. The committee mostly does not. Then the part I care about. I order the scan for a kidney stone. At 2 am the read comes back: stone, and a flag. Probable colorectal mass, model-detected. What do I do with that?
Today the honest answer is that I tell the patient, I write "follow up with GI" on the discharge paperwork, and the loop closes some of the time. The ED already has a process for results that arrive after the patient leaves. Positive cultures get a callback, a nurse, a list, a phone call until someone answers. A model-detected mass belongs in that process, with an owner and a tracking list. Referral is the easy part. Whether the scope happens is the system.
One more thing radiology will have to contend with. A local validation takes months. The model's successor ships in three. Validating once and deploying forever cannot work at this cadence. The tool has to be checked the way a lab analyzer is checked, continuously, against known results, with an alarm when it drifts.
A model can now find a cancer on a scan nobody ordered it for. Who owns that result?
Takeaway: stop working on verifiable, pure-digital-world, well-known tasks. These tasks are going to be solved by those with maximum compute and most intelligent models. Three ways out:
- Non-verifiable tasks, e.g., writing, art, designing a new product, etc.
- Tasks involving physical world or humans, e.g., robotics, manufacturing, sales, education, etc.
- Niche domains, e.g., Quant where public information is rare (but nothing stops AI from self-evolving in Quant given its verifiability)
We congratulate Levent Alpöge and Tristan Buckmaster on their remarkable mathematical work.
We (the researchers and the agents) did not see any of their work through any means until they released it publicly — in particular, no specific user data was accessed in order to solve this problem.
While unlikely, we cannot rule out that de-identified data derived from their usage of our products helped improve our models.
However, our proofs differ significantly and even the precise results proved are different in the Euler case (forced vs. unforced).
Sameed Khan retweeted
arXiv -> quickarXiv
Papers are often written in convoluted language that is hard to understand
Swap arXiv -> quickarXiv on any paper URL to get an instant blog with figures, insights, and explanations. Now extracted with @Zai_org's GLM OCR 🚀
Also includes code + author tweet
Sameed Khan retweeted
🚢 Marin 535B-A23B started training this week! As usual, the whole process is open.
Voyage plan: pretraining (80%) + midtraining (20%) on 18.75T tokens on 11 x GB200 NVL72 for ~3 months (2.7e24 FLOPs). Post-training will follow.
Before kicking off the run, we trained a 4-rung scaling ladder from 1.6B-A61M (48B tokens) to 27.7B-A1.2B (926B tokens) to debug issues, and to make a forecast of our hero run. This is by far our biggest run, so definitely expecting the unexpected.
Sameed Khan retweeted
The gold standard for producing PDF documents (especially books and journal articles) has been LaTeX. @typstapp re-engineered the entire process in an incredibly elegant extensible way. On my MacOS LaTeX (TexLive) takes 9.1GB of disk space. Typst takes 43MB. Not a misprint.
Sameed Khan retweeted

Chubby♨️@kimmonismusAug 16
Germany
GermanyConnected via Germany App StoreAccount-level information, not a live location or per-post device.
watermarks-remover for AI content reaches ~11k stars on github.
People really hate the watermarks. And i fully understand them.
WATERMARK STRIPPER HITS 10,000 STARS DAYS AFTER ANTHROPIC SHIPS PROVENANCE
Anthropic detailed how Claude's text watermark works last week.
By this morning a MIT-licensed repo that strips it has 10,000 stars, targeting Claude, SynthID-Text and OpenAI marks, plus C2PA and EXIF in images and PDFs.
github.com/guillaumemeyer/wa…
Today we're opening up the DoorDash CLI in limited beta.
`dd-cli` lets you order DoorDash directly from your agent: search stores, find the best deals, check out, and more.
Early access for US/Canadian macOS developers by waitlist. Excited to see what folks build!
Sameed Khan retweeted
Coincidentally, 3 out of the last 4 weeks I could not include a link to Spotify when releasing my podcast episode, b/f Spotify was down.
2x an outage in publishing the podcasts, 1x the complete web player down
Have not experienced such poor reliability from Spotify in forever
Sameed Khan retweeted
You can now give your agent deep knowledge of millions of papers in one line with #paperclip!📎
>8 million papers natively indexed for agents.
Much more thorough + often 10x faster than standard deep research.
Just add the paperclip mcp (instruction below).
Sameed Khan retweeted
Scrap the journals and formal peer review. A better system could be a dynamic arXiv-like document (including a verification system similar to arXiv) where new versions are assigned new DOIs, coupled with a comment section.
Comments get DOIs. Helpful comments are incorporated into the living manuscript as edits or citations. Substantive additions are given co-authorship in updated version. Substantive critiques or re-analysis of data by another group get cited because they have DOIs and become part of the record of knowledge in this topic.
Comments can be anonymous, but if you want credit and H-index growth, it has to be under your name.
Sameed Khan retweeted
This is a big deal. Frequentist statistics have done a lot of damage to medical science. People rely on P values without really understanding what they mean. Many faulty conclusions have been made because of them.
Once you understand Bayes methods, you’ll never rely on frequent tests again. Bayes methods are completely aligned with clinical thinking and should be the standard methodology used for statistical analysis in clinical research.
This is a big step forward in improving the efficiency of clinical trials of drugs and biologics, and a big day for @US_FDA which I've been dreaming of for decades : fda.gov/news-events/press-an… #bayes #RCT #clinicaltrial #pharma
Sameed Khan retweeted
Utah has become the first state to allow AI to renew medical prescriptions with no doctor involved. The company, Doctronic, also secured a malpractice insurance policy for their AI. Their data also shows that their system matches doctors treatment plans 99.2% of the time.
Sameed Khan retweeted
We need a shorthand way of saying:
"An AI did the work, but I vouch for the result"
Saying "I did it" feels slightly sketchy, but saying "Claude did it" feels like avoiding responsibility
Sameed Khan retweeted
We just published a model that does automated data extraction from Cardiac MRI reports. Let AI help make chart reviewing easier and the data collection process faster.
Thank you Drs. @DebbieKwonMD & Chen for your mentorship on this project!
doi.org/10.1016/j.jocmr.2025…
Today I handed Claude a document that I've been growing for...years on building an orchestrator/distributed runtime that I had only purely theorized possible. One we've been working towards.
It would have taken me probably months to code by hand. Building on 5 years of work and 10 years of experience.
Claude wrote all the code in Golang in 4 hours. I'd always actually wanted it in Rust cause I thought it would be easier to express, so I threw it in a loop with a "Rewrite it in Rust and make it as succinct as possible"
I went and ate a burrito. I came back and it was done.
That's the world we live in now.































