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Joined May 2020
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Sacha retweeted
My first interview with @sachaker, Founder & CEO of Babylon Biosciences.
Babylon is on a quest to cure Alzheimer’s.
1:00 History of Alzheimer’s research
8:09 Why tackle this problem
12:22 Axon degeneration
13:57 Structuring Babylon to survive many failures
15:24 Self-financing Alzheimer’s moonshots
19:01 Viagra
19:59 Swanson linking and Raynaud syndrome
24:16 Most efficacious drugs for Alzheimer’s
27:29 Experience starting Babylon
31:34 Attracting mission aligned people
36:24 Filtering for missionaries vs mercenaries
41:07 Lack of agency causes burnout
46:02 Living without a phone to reduce distraction
49:31 Why the information to cure Alzheimer’s might already be out there
54:19 How AI changes things
55:36 Controversial science
1:03:11 Volunteering at memory clinics
1:04:28 Impact-per-dollar and being scrappy
1:07:55 Internalizing pain when you make a bad decision
1:09:26 Time to last embarrassment
1:10:51 Risk taking
1:12:57 What causes cognitive impairment
1:22:11 What keeps him up at night
Sacha retweeted
Alzheimer's Competitive Landscape 🧠
+ a deep dive into the unmet need and future of treatment:
Sacha retweeted
Where do decisions get made? Decisions about sensory information are thought to arise high in the cortical processing hierarchy. Our @NatureNeuro study challenges this, showing that decision signals consequential for behaviour are found at the earliest cortical processing stages.
it really is incumbent on anyone in a position to effect true change in the world to do so. agreed 100%.
this article really resonated with me. i highly recommend
History is defined by top players pursuing good quests.
Today, we are in a crisis. Silicon Valley's best — our top operators, exited founders, and investors — are almost all on bad quests.
@traestephens and I write about quests in @PirateWires
piratewires.com/p/choose-goo…
the research i was doing with some talented folks at UCL several years ago was published recently.
glad to be a co-author :)
nature.com/articles/s41593-0…
it seems way easier to optimize a scaled process than to scale an optimized process.
why is this not discussed more in SaaS and beyond?
if anyone wants to join a virtual coworking space with me today, i'll be on there all day.
(for anyone who wants a space to just quietly get work done)
meet.google.com/nxk-pvur-hff
Sacha retweeted
This chart shows the proportion of original films to sequels in the worldwide top 50 grossing releases over the last few decades.
Are we running out of ideas? Or is it just nostalgia?
ALT Credit: u/spicer2