Real life is a group chat. Mine: 14 people, one house in Maine, and at least one family member who never answers texts. We built @heyollieai from day 1 to be in that group chat. This summer, Ollie took my role as family travel coordinator off my plate so I could enjoy the trip.

I’m very happy to announce that @multiplylabs 𝗵𝗮𝘀 𝗿𝗮𝗶𝘀𝗲𝗱 𝗮 $𝟳𝟱𝗠 𝗦𝗲𝗿𝗶𝗲𝘀 𝗕, led by @NantWorks, with the participation of new investors @AstraZeneca, Lingotto, Ora Global, @Teradyneinc , and Strange Ventures. Thank you also to our returning investors, including @fiftyyears, @cascapital, @Lux_Capital, and @foundersfund. Tens of billions of dollars are flowing into AI drug discovery, and AI is now designing more drug candidates (including personalized therapies!) than the industry will ever be able to manufacture with old-fashioned manual processes. It’s crazy that some of the most advanced medicines on the planet are still made largely by hand! I don’t think it’s acceptable that, while the science works so well, it’s still not possible to make enough therapies at an affordable price. The Multiply Labs team and I believe that 𝗿𝗼𝗯𝗼𝘁𝗶𝗰𝘀 𝗶𝘀 𝘁𝗵𝗲 𝗼𝗻𝗹𝘆 𝘄𝗮𝘆 to enable the next generation of biological medicines to reach truly industrial scale. This round enables us to turn this future into reality, by scaling our supply chain and the automated learning capabilities of our robots. A warm welcome to @IleanaPirozzi, who joins our Board. And the biggest thank you to the @multiplylabs team, who build & train these robots every single day! We are super excited to keep building, and we will have a lot more to show you very soon! Coverage in the thread below!

DO AGENTS HAVE NETWORK EFFECTS? We are seeing a new wave of general purpose consumer-friendly agents, and it’s causing many thousands of AI startups to re-evaluate their place in the market. Will these new horizontal players take over completely? Will it be winner take all? Can products that focus vertical use cases survive? The new wave of products - Muse, Town, Instinct, Grokbot, etc - come from taking the power and magic of Openclaw/Hermes but wrapping it in polished, secure, consumer-friendly experience. This is only the beginning, and soon every major tech company will throw their hat in the ring and thousands of startups that have been working on vertical agents in X (travel, shopping, family, work, SMB, etc etc) have big existential questions to answer. The simple case against winner-take-all dynamics: These agents are tools, not networks. They inherently provide a solo experience, and although packaged as chat experiences, they don’t have network effects the way that Whatsapp or phone networks do. They’re more like email clients - I can use Superhuman and someone else uses Outlook and someone else is on Gmail, but in the end we just send email to each other. In that metaphoi, if a Muse agent encounters a Instinct agent, they will just figure out how to talk to each other by building APIs, or using email/messaging/etc., so that there’s no advantage to everyone running the same thing. Further, you can swap out the underlying LLM - as we saw in the Claude vs Clawdbot saga - things will still work. The memory and underlying context are just text files, and AI are great at porting things from one system to another. So where’s the moat? Just because they are tools today doesn’t mean they can’t evolve into networks. As I’ve written about in the past, instead of discussing “network effects” as a vague/amorphous concept, let’s instead overlay it against core KPIs each product has to build against: - Acquisition network effects: More users** = lower CAC, higher virality, more signups - Engagement effects: More users = higher retention, deeper usage, more frequency - Monetization effects: More users = higher ARPU, higher conversion, more share of wallet (**PS. and by “more users” of course I actually mean, of course, higher network density with more interconnection within/across networks. Not scale effects) So looking at these sub-categories of network effects, you might ask: What are the features that you’d build to actually create network effects in agents? How does this category become winner-take-all? Acquisition: In the pre-AI world, network effects in customer acquisition were driven by users taking actions that then bring in even more users - whether that’s sending an invite, sharing a piece of content, or getting mentioned in a comment. Those users would then join the network, repeat the same actions, creating more viral loops that would throw off more users. In the post-AI world, both users and agents can initiate these loops. An agent might suggest, “hey, do you want me to help organize a New Years celebration with family” and then might pull together a group chat with your siblings, in-laws, and parents. It might build a microsite for the event and ask people to sign up and RSVP, creating an opportunity to generate a signup. Or for work, you might finish a slide deck and your agent asks if you want to pull together a meeting to present it to your team. When it does that, it might create a prep doc, take notes, and host it all on a microsite that engaged others. These types of agentic viral loops need a few things to work: They need to be able to plug into your contacts, and to have enough context to know when to loop which people into which projects/events/activities. They need access to communication channels like email/messaging/otherwise, specifically where they can reach potential users, as this serves as the viral substrate for propagation. The magic will be how to get all of these things without being creepy, and to create enough trust to reach out to friends/colleagues/etc on your behalf, without being too push. No one wants an agent that says, “hey Andrew would like to get lunch next week” followed by “and sign up for this agent to agree!” - it has to be better and more subtle than that. Many viral loops in the pre-AI era, particularly in the workplace, were built on a content creation loop - you use Google Slides to make a thing, you share a link, and then people would view it. Eventually they might make their own. Many products like Figma, spreadsheets, Notion, Canvas, are all built on this loop, and so are YouTube, Instagram, etc. In the agentic world, you might start by talking to your agent about interior decoration ideas, and it might ultimately build you a Pinterest-like board and make it easily shareable with others. It might build you a spreadsheet mini-app with a budget, a schedule, etc., and again, make it easily shareable. It might volunteer to do this inside a group chat with your friends, and if they want to view it, they should sign up and get their own agent too. If the content creation loop works for agentic virality, I think it means there’s a big incentive for every agent to volunteer to make visually-appealing, shareable content, do this often. AI is so good at codegen that creating a one-off disposable artifact will probably be more useful than not. And there’s a big incentive to drive virality by building/owning the content yourself as the agent. In the interior decoration example, it would be more viral to create a standalone version hosted by the agent, rather than building an actual Pinterest board, or to build a self-contained mini-spreadsheet rather than creating a GSheet. A properly tuned agentic viral loop will do the former because it helps spread the agent, rather than helping spread Pinterest/GSheets. This might all sound like horrific spamminess to you, but I think it might be done tastefully. If an agent is high-retention and high-usage, you’ll have many shots on goal to gradually invite your friends onto the same platform as you. The first shot might come from an invite loop that says your colleague/friend wants to set up a place to share photos/coordinate calendars/etc., and even if you say no, over time, your friend might share very useful microsites for projects or events or research that’s relevant, and you might decide that you want to sign up to leave a comment, but then eventually you might try the other functionality as well. Engagement: It’s easy to imagine that in a world where everyone by default has super intelligent agents that product engagement in agents would go up. The simple argument is that the ubiquity of agents would lead to more successful task completion, making agents more useful and applicable to more problems. Routine tasks like scheduling something or summarizing/sharing notes from a meeting, would happen instantly if it ran through agents and you removed humans completely. As agents become more successful over time, not only with your own tasks but in coordinating larger and more complex multi-user decisions, you’d end up using them more. However, this does not answer the question of network effects. The question there is, does your agent get better when other people are all using the SAME agent? As I said earlier, the argument for NO is if each type of agent runs on a frontier AI model, can talk to other agents (all different types) in real-time via email/messaging/APIs/connectors/etc. Then there’s not much leverage. If you’re just organizing a meeting or a dinner party or meeting the agents just ask each other in real-time - and even if they are heterogeneous - they can use email and calendars and figure it out. But some tasks do benefit from everyone running the same agent, because you get the benefits of centralization: Trust, speed, identity, discovery, etc. Some examples: - “Who are 10 people in San Francisco that I should meet?” - agents can’t just ask each other to find an optimal solution - “Find me a VP of Engineering who isn’t publicly looking for a new job, but would leave for a fast-growing startup that pays X in stock” - there’s a mix of private and public info here, and an agent of a passive jobseeker might lie if the asking agent is not trustworthy - “Who’s a trustworthy seller of X that I should buy from?” - reputation might be gamed, and it might be better to have a global source of truth - “Help me pick out the best dinner in the next 5 minutes that my friends and all their +1s would like, incorporating allergies/schedules/locations” - real-time solution incorporating a bunch of shared context - … and even more so, if you imagine that there may be agents that lie, exaggerate, or otherwise to benefit their humans For the above examples, you could imagine Muse/Town/Instinct/whatever building a shared network+context layer that understands the network, its relation to public/private data, acts as a system of record for identity/trust, does multi-sided marketplace matching, etc. Then it would allow only its agents access to this platform, and agents outside of the network wouldn’t have access. If you’re part of this network, and are contributing data, your agent gets more useful over time. The network gets more powerful over time. The counterpoint to this counterpoint is that perhaps new startups will fill the void as a series of agent-facing point solutions, making it possible for people running agents of all times to interface with each other. Perhaps Muse creates a proprietary ecommerce marketplace that only Muse agents can use, but perhaps there will just be a next-gen eBay for any agent to sell to any other agent, and this service maintains central reputation/identity at that layer. In other words, perhaps the centralization will still happen, but just at a layer above agents. Most likely both will happen - every large tech company adds chat, commerce, search, etc, but also there are pure play versions of each of these. But this feels like more fragmentation than a true winner-take-all. Some parting thoughts: My argument in this writeup is simple: Agents don’t inherently have network effects. If all we build are super-intelligent assistants that can use tools and talk to each other, then the category might look surprisingly fragmented. Your agent can talk to my agent, just as Gmail can send email to Outlook, and there’s no particular reason we need to use the same one. Better models, UX, integrations, memory, and distribution might create very large companies, but those are not network effects. But the next gen of agents have a big opportunity design network effects in their interactions. On acquisition, they can turn the things they create—documents, events, websites, research, group chats, plans—into viral objects that naturally pull other people in. And on engagement, they can create shared networks of identity, reputation, relationships, private context, and intent that make the agent increasingly useful as more of the people around you join. There’s many ways for these network effects to instantiate. If we’re lucky, things will look more like the open web - mostly decentralized, with bits of centralization to make certain tasks smoother. Identity could become an open protocol. Reputation could live in marketplaces. Commerce could happen through an agent-native eBay. Professional discovery could happen through an agent-native LinkedIn. Agents could remain interchangeable clients sitting on top of a constellation of networks and marketplaces, much as browsers and email clients do today. In that world, enormous network effects emerge around agents without producing a winner-take-all market for the agents themselves. My guess is that we’ll see a fight over exactly this boundary. Every major horizontal agent will try to pull valuable network functionality inside its walls: host the artifact instead of creating a Google Doc, execute the transaction instead of sending you to Amazon, make the introduction instead of searching LinkedIn, create the event instead of using Partiful. Every time it does this successfully, it converts somebody else’s network effect into its own. Meanwhile, every incumbent network and a new generation of startups will have the opposite incentive: make their networks universally accessible to every agent so that no horizontal agent can recreate and capture them. This is why I don’t think the interesting question is simply, “Will agents have network effects?” Of course some will. The much more consequential question is: Where will the network effects live? If they live primarily in open protocols and specialized networks, we may end up with thousands of agents competing on intelligence, personality, UX, specialization, and price, all interoperating with the same underlying ecosystem. Vertical agents can thrive in this world. But if a few horizontal agents successfully accumulate identity, relationships, private context, reputation, latent intent, and distribution - and keep those assets proprietary - then switching agents starts to mean leaving your network behind. Next couple years will be very fun to see how this plays out.

.@OpenRouter co-founder Alex Atallah on personal agents: 10 specialized chiefs of staff beat one universal agent. One job each means you can see exactly where it's failing. "The worst part about doing cross-domain joins with your personal agent is that the more work you give it, the more understanding of what's going on you're sacrificing." "And no one is taking responsibility for that sacrifice. Agents don't have any responsibility." "With a universal agent that's doing all things, I can't adjust how much understanding I'm sacrificing." "It points me towards: maybe down the road, the sub-agents people use will be very vertically focused, and we have a chief of staff type agent that coordinates between them." "You need vertically focused agents where this agent is more responsible, psychologically, for these things. I want quality checks that make sure it's doing those things correctly. It doesn't need to focus on anything else, it has one focus area." "I wonder if that's going to help people get at least a loose sense of responsibility on top of agents." @alexatallah

Google just led a $20m round into a complete rip-off of my startup, Fastlane. (skip to 55 seconds to skip context) This isn’t something I’d normally talk about, but a line has been crossed. This disgusting and egregious behavior honestly makes me sick. Fortunately, there is nothing anyone could do to stop us from winning. Especially not some unimaginative NPC’s. Good luck fellas.

I want a neighborhood dive bar that charges a $120/year membership and pours $3 beers

The Consupocalypse Consumer commerce is having its own SaaSpocalypse moment thanks to Muse, Instinct and personal agents. (eg: Month to date Booking share price is -21%, Expedia is -18%, and Airbnb is -18%) IMO, when the dust settles, companies that will be left standing will have some or all of the following: 1. Differentiated physical (not just digital) infrastructure and fulfillment 2. Hard to access supply 3. Powerful local network effects 4. Proprietary data loops that allows better personalization than a general purpose agent can 5. Differentiated Membership / reward programs that drive true loyalty 6. Consumer trust We will go beyond theoretical moats discussions and truly see which moats are durable.

.@benthompson gives his recommendation on how Meta should market Muse: "The way to frame this is to say: 'We're not helping you be more productive, we're helping you get rid of annoying crap in your life.'" "It needs to be framed more as a pain relief as opposed to this aspirational, 'I'm gonna be so productive and get things done.'" "People don't care about being productive. Employers care about their employees being productive. But once you're off the job, you just want to go home and watch TikTok." "The way I think this is going to land is through Instagram Reels or TikTok with people actually showing stuff they do and people say, 'That's amazing. That would make my life so much easier.'" "It really is a show-not-tell sort of technology."

Google needs to buy Instinct, they need that product DNA, Notebook isn't going to cut it. Instinct, Muse, Grok Bot, etc., are social ai. I've seen this play out before... I was at Google+ for 3-months running mobile, I tried buy instagram but I was two steps down from Larry, so I didn't have the pull (Kevin had told me Zuck was sniffing around), my SVP said it was 'too expensive.'.. killed me. I bounced to Google Ventures.