@rowleyresearch

Scientist at the University of Utah studying #platelets, megakaryocytes, and gene expression. All views expressed are my own.

 Salt Lake City, UT
Joined June 2009
  • Tweets76
  • Following156
  • Followers273
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Our AJHG study introduces high-efficiency CRISPR HDR in CD34+-derived megakaryocytes to functionally classify platelet gene variants in their native context. We resolve several challenging Glanzmann Thrombasthenia VUSs in ITGA2B/ITGB3 #Platelets #CRISPR cell.com/ajhg/fulltext/S0002…

Functional classification of platelet gene variants using CRISPR HDR in CD34+ cell-derived megaka...

Using CRISPR-edited CD34+ cells differentiated into megakaryocytes, CRIMSON HD models Glanzmann thrombasthenia phenotypes, providing a robust, lineage-relevant framework for functional testing and...

cell.com
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Functional classification of platelet gene variants using CRISPR HDR in CD34+ cell-derived megakaryocytes: The American Journal of Human Genetics cell.com/ajhg/fulltext/S0002…

Functional classification of platelet gene variants using CRISPR HDR in CD34+ cell-derived megaka...

Using CRISPR-edited CD34+ cells differentiated into megakaryocytes, CRIMSON HD models Glanzmann thrombasthenia phenotypes, providing a robust, lineage-relevant framework for functional testing and...

cell.com
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The Rowley Lab (plateletlab.com) is hiring post-docs! Are you interested in mitochondria, megakaryocytes, platelets, hematopoietic stem cells, or CRISPR/CAS9 functional screens? Message me or apply at utah.peopleadmin.com/posting… .
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Jesse Rowley retweeted
SpaceX
@SpaceX5 Nov 2024
Watch Falcon 9 launch Dragon to the @Space_Station xitter.cf/i/broadcasts/1djGXrAWV…
0:00

SpaceX

CRS-31 Mission

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The In-Press Preview of @alison_livada work is online jci.org/articles/view/181111 A lot of work went into her paper, finished just in time to return to the MD portion of her studies.
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Blocking a relatively unknown #cytokine creates a fountain of youth. #ForeverYoung nature.com/articles/s41586-0…

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Nature - IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.

nature.com
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BDUC (bleeding disorder of unknown cause ) patients show reduced platelet adhesion/ thrombus formation.➡️ To diagnose BDUC, platelet light transmission aggregometry should be performed as a minimum assessment. Platelet transfusions can be a potential treatment option.
JTH@JTHjournal10 Jul 2024
On #Cover #July New @isth SSC paper on bleeding disorders of unknown cause @MahaOthman8 @nikmutch @@Mtl_PlateletLab jthjournal.org/action/showPd…
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Want to learn about platelets, megakaryocytes, hematopoietic stem cells, RNA-seq, CRISPR, and high throughput functional screens? We're hiring a post-doc: utah.peopleadmin.com/posting…
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Andrew Johnson@ADJomics12 Apr 2024
Our new article on factors influencing Platelet assays (e.g., blood draw time, time to test, age, sex, medications, technician, seasonality) and inter-assay correlation in >3,400 people is now online: sciencedirect.com/science/ar… @RPTHjournal @isth
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Jesse Rowley retweeted
Abdullah Khan@AbAttacks27 Mar 2024
Morning everyone! Pleased to share a detailed protocol of our bone marrow organoid approach in @NatureProtocols : nature.com/articles/s41596-0….

Generating human bone marrow organoids for disease modeling and drug discovery

Nature Protocols - This protocol can be used to generate three-dimensional vascularized bone marrow organoids from human induced pluripotent stem cells. The organoids contain key stromal and...

nature.com
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Pre-print of our work led by Chen Li is online at Circ Res. Chen put a lot of data together to identify new ways platelets regulate monocyte immune responses. ahajournals.org/doi/epdf/10.…
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Important step forward in #PrecisionMedicine - Platelet RNA Biomarker of Ticagrelor responsive genes Is associated w #platelet fxn and #cardiovascular events - Collaborative effort betwn @DukeCardiology and @NYUCVDPrevent @TessaJBarrett @nyulangone ahajournals.org/doi/10.1161/…

Platelet RNA Biomarker of Ticagrelor-Responsive Genes Is Associated With Platelet Function and...

BACKGROUND: Identifying patients with the optimal risk:benefit for ticagrelor is challenging. The aim was to identify ticagrelor-responsive platelet transcripts as biomarkers of platelet function and...

ahajournals.org
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Jacob et al found that #MFN2 promotes #mitochondrial fusion in #megakaryocytes to maintain #platelet lifespan, & impacts function, ischemic #stroke, & #lung injury in mice at ahajrnls.org/3S6Skft @rowleyresearch @racampbell04 @FrederikDenorme @IntmedAbel
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Jesse Rowley retweeted
E. Dale Abel@IntMedAbel19 Jan 2024
Here is the next one in @CircRes congrats to @rowleyresearch @jacob_shancy @racampbell04 @RhondaSouvenir @UU_MolecularMed showing #mitochondria dynamics via MFN2 regulating platelet activity. A good week for papers. bit.ly/4aHT8Qo
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Who are the leaders in the field of inherited platelet disorders? This is what ChatGPT said. Paul Bray is retiring this month. He has been a stellar mentor and I have been fortunate to work with him. Shout out to the others too for their work recognized by AI :)
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The PAR4 Thr120 variant influences platelet-neutrophil interactions and stroke outcomes: buff.ly/3sZDTRn @racampbell04 @FrederikDenorme @MaryCushmanMD #Hematology #Neuroscience
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Glad to see Dr. Abel, my former K award co-mentor, featured in Cell. He is an excellent scientist and mentor. cell.com/cell/fulltext/S0092…

E. Dale Abel, MBBS, DPhil, David Geffen School of Medicine, University of California, Los Angeles

Dr. E. Dale Abel is recognized for his significant contributions to our understanding of the interface between metabolic and cardiovascular disease. He is a leader, mentor, and champion of equity,...

cell.com
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Jesse Rowley retweeted
Kim Martinod@kmartinod12 May 2023
. @FrederikDenorme knocks it out of the park once again with a knock-in model investigating a (druggable) key gene variant leading to ⬆️platelet activation ⬆️NETs and ofc ⬆️stroke risk. Definitely highlights the huge need for greater #diversity in clinical trials
Robert Campbell@racampbell0412 May 2023
Outstanding talk from Brinkhous finalist @FrederikDenorme at #vasculardiscovery23. Great session with great talks from @Colin_E_Evans @WSteveHur @AmilyLiGuo
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