PhD at Cellular Systems Genomics Group-@CarrerasIJC. Interested in #Cancer and #Immunology through #Singlecell🧬💻
Joined February 2021
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PhD✅
Another thesis successfully defended 👏
Congratulations to Aina Rill (@eli_mereu's lab) with her work on "Mapping Inflammation and T cell Dynamics with Single-Cell Genomics" 🧬💻
Well done, new doctor!👩🔬🎓
Aina Rill retweeted
We have now written up a preprint on this!
biorxiv.org/content/10.1101/… @theHumanBorch
Aina Rill retweeted
It took 3 years, 4 rounds of reviews, 96 VISIUM samples, 10 cancer types, and 1 clinical trial, but it's finally out:
The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity
Here's what's new 👇
cell.com/cell-reports/fullte…
Aina Rill retweeted
🏆Congratulations to @rill_aina for winning a Molecular Oncology prize at the 2024 @CarrerasIJC Symposium, with her poster "Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias"👏
Very honored to have received one of the Molecular Oncology Poster Session Awards last week from #IJCSymposium “Updates on Genetics and Epigenetics of Haematological Malignancies: From Knowledge to Applications” at @CarrerasIJC ✨
Aina Rill retweeted
So i'm very happy to say that my very talented honours student has reimplemented the entire trajectory workflow in R, intersecting with @theHumanBorch's scRepetoire! Code is now live github.com/tuonglab/dandelio… but lacking vignette; will be up shortly!)
Aina Rill retweeted
Published today @NatureBiotech: @CarlHJune and I reveal how CAR T cells are finally tackling solid tumors!
@PennPPA @PennMDForum
nature.com/articles/s41587-0…
My first first-author paper is out!! Check out this incredible science done in collaboration with @MerGuMu and @Menendez_Lab @eli_mereu 🧬🧫💻💖
🚨Researchers from the @Menendez_Lab and @eli_mereu Lab, @MerGuMu @trincadojl @rill_aina describe at @CellRepMed the molecular features making a CAR-T cells infusion successful 💪
Read the news piece at 👇
carrerasresearch.org/en/news…
Results show objective features in the infusion product may predict future therapeutic success, advocating for a more precise quality control.
Also, characteristics of the CAR-T expansion within the patient are related to efficacy and could be used as early warning.
Thanks to funders 🫶 @contracancerINV @FundlaCaixa @unoentrecienmil @fcarreras
Check out how we found intrinsic factors of CAR-T cells that may play a major role on its clinical success by single-cel multiomics!! 🧬💻💖
Paper available in Cell Reports Medicine:
cell.com/action/showPdf?pii=…
Aina Rill retweeted
🚀 New research alert! Dive into the single-cell multi-omics of CD19-CAR+ and CAR- T cells! A promising step in #CARTcell therapy for better outcomes! Led by @MerGuMu, @rill_aina & @trincadojl from @Menendez_Lab and my lab! Enjoy! cell.com/action/showPdf?pii=…
Aina Rill retweeted
STAMP is OUT!
Sequencing-free #singlecell RNA and Protein profiling.
Game-changing approach for scalable and cost-efficient analysis of single cells.
The future starts today!
Amazing @LGMartelotto @DrJasPlummer
biorxiv.org/content/10.1101/…
Aina Rill retweeted
Brilliant ✨ #YoungResearchers Seminar yesterday with Aina Rill, from @eli_mereu’s lab!
We have learnt more about her project "Integrative #SingleCell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias". Great work! 👏
Aina Rill retweeted
📢Our lab at the @CarrerasIJC is looking for candidates for the competitive PhD INPhINIT incoming fellowship from La Caixa Foundation. We work on the application of #singlecell genomics and ML to improve cell-based immunotherapy in Myeloma and others B-cell neoplasms. Plz RT!🔁 – at Barcelona, Spain
Aina Rill retweeted
Our multimodal model to combine TCR sequences with scRNA-seq is finally out. The most interesting part for me was observing a clear case where the combination of TCR sequence and cell state (RNA) preserved both clonotype and cell type information, leading to a more holistic cell representation that captures phenotype and functionality. We also decompose the contribution and importance of each modality. This was a really fun project spearheaded by @DrostFelix, whose amazing perseverance during a long review period, and collaboration with @schubert_benni and other fantastic collaborators, made it possible.
Read the paper :nature.com/articles/s41467-0…
Aina Rill retweeted
Really glad to see our work published in @Nature @CommsBio: nature.com/articles/s42003-0….
This analysis of 39 fragment screening experiments sets the scene for our future work on function prediction for ligand sites across the @PDBeurope. @gjbarton @bartongrp @stuartmac44 @CallumMIves
Our new paper: "Classification of likely functional state for ligand binding sites identified from fragment screening" by @JavierUtges @CallumMIves @stuartmac44 now available as a preprint - poster at #ISMBECCB2023 on the next step in this work: doi.org/10.21203/rs.3.rs-318…
Aina Rill retweeted
Excited to share my first first-author paper: T-FINDER! 🎉 We've crafted a super-sensitive TCR signaling reporter with an innovative antigen processing system. Explore how we identify unknown peptide:HLA ligands - Check it out here on @ScienceAdvances: doi.org/10.1126/sciadv.adk30…
Aina Rill retweeted
Very happy to share our #singlecell #multiomics analysis of #MDS patients and clinical response to #HMA in @CRC_AACR @ManelEsteller
Check it out!✨ aacrjournals.org/cancerresco…
📚 Excited to dive into the world of single-cell multi-omics!!🧬🔬
You can check out now our manuscript: "Integrative single-cell multi-omics of CD19-CAR+ and CAR- T cells suggest drivers of immunotherapy response." #SingleCell
#Tweetorial coming 👀biorxiv.org/content/10.1101/…
Key Takeaways from our CAR-T Study:
⚖️CD4/CD8 ratio's impact
😮💨Exhaustion in IP
🔬CD8+ cytotoxic T cells' significance
👀Gamma delta T cells' role
With this knowledge, we strive to enhance treatments and pave the way for improved patient outcomes.
🙏 Thank you for reading my first co-author paper! For a detailed explanation, check the entire paper to uncover the secrets revealed by sc multiomics. Feel free to read and share ♥️✨
And of course, this project couldn’t be done without the collaboration of @MerGuMu @trincadojl