biosciences/-tech, politics & debating
Joined June 2017
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Our new preprint on high-throughput PBK modelling for #dermal exposure is now available 📄👇
“High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics” doi.org/10.1101/2025.11.12.6…
whether this is due to greater variability in the underlying PK data and clinical study protocols, or because dermal absorption is inherently more complex. Still, we conclude that despite the challenges in capturing absorption dynamics, the method offers a pragmatic and...
Still thinking that Drug-Induced Liver Injury (DILI) is hard to foresee? That LogP and Dose are good DILI predictors? Wondering why DILI often manifests idiosyncratically?
Then you should read our new preprint! 📄👇
𝗛𝗼𝘁 𝗼𝗳𝗳 𝘁𝗵𝗲 𝗽𝗿𝗲𝘀𝘀: the second peer-reviewed paper of my PhD “Potential Systemic Availability (PSA) Classification of Chemicals for Safety Assessment” has just been published in Environment International and it’s fully open access.
🔗 doi.org/10.1016/j.envint.202…
Huge thanks to my co-authors Andrew Worth, Alicia Paini, Lars Kuepfer and Stephan Schaller, and to everyone who debated these ideas at the NAM Designathon workshop in Ispra 🇮🇹. Your insights were invaluable!
🤝 Interested in applying PSA to your own chemical portfolio? Let’s connect and chat!
#OpenAccess #ExposureLed #NGRA #ChemicalSafety #NAMs #PBK #RiskAssessment #Toxicology #RegulatoryScience