Why do so many people take NAD+ boosters and feel almost nothing?
According to Josh Conway review, quantity matters less than the actual response capacity of SIRT1 under stress. The same levels of SIRT1 or NAD+ can produce very different results depending on where the NAD+ is located, which isoforms are present, and the cell’s stress history.
This brings to my mind iron and copper – and not only them: in many systems, quantity is not the same as functional availability.
Reviewers publishing in Biology have elucidated SIRT1 functional reserve as an aspect of aging, describing how its depletion is an upstream cause of age-related disorders at the cellular level and explaining why many prospective therapies that increase SIRT1 and NAD+ have not had promising results.
👉 Read more: lifespan.io/making-sirt1-and…
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Cholesterol discussions are so popular, but I often notice that bile acids are rarely included, even though they are a major route of cholesterol disposal and regulation. Mind you that even doctors rarely include bile acids reasoning in their clinical practice.
A recent randomized crossover trial in postmenopausal women helps illustrate this matter. Zhang et al. (2026) found that diets higher in palmitic acid (16:0), compared with stearic acid (18:0) or oleic acid (18:1), altered the bile-acid pool and reduced the activity of key regulatory signals (FXR/SHP), that normally help the liver control cholesterol handling.
This is a direct bile-acid-mediated effect that is usually left out of the conversation. ajcn.nutrition.org/article/S…
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The main dietary source of excess 16:0 in many processed foods is refined palm oil.
Beyond the fatty-acid profile, it can carry 3-MCPD esters from high-heat processing, with evidence of restricted fetal growth.
xitter.cf/raquel08/status/210209…
High-heat foods – especially those with refined palm oil – can carry 3-MCPD esters. Gestational 3-MCPD restricts fetal growth via placental vascular senescence: Ezh2 silences Fmo1 and depletes taurine.
Cheap palm oil helped replace trans fats. Now, ~50 Mt go into food yearly, and many companies advertise it as a plus...
pubs.acs.org/jafcau/article-… (He et al. 2026)
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Keep in mind that not all saturated fats act the same. Stearic acid (18:0) comes from palmitic acid (16:0), yet the body handles them differently – including through bile acids, one of the main ways the liver clears cholesterol.
The popular advice still boils down to “cut saturated fat and take a statin.”
Statins mainly slow cholesterol production. They do little to improve how much cholesterol is actually eliminated via bile acids, or how the specific mix of fats you eat influences that pathway.
Lipidomics is teaching us that ratio – and which saturated fat – often matters more than the popular advice.
xitter.cf/raquel08/status/187914…
I wish lipidomics was that simple for quotes! Depending on the cancer = different analysis results... maybe because 18:0 originates from 16:0, dessaturases and FAs ratio, FA/MUFAs are all in play (+ tumor cells accelerate de novo lipogenesis), etc. Rgds PUFAs, n-3s rarely show amplification comparing to n-6s... A strong cofounding factor is different or not sensible protocols used for membrane lipidomic analysis
We just launched the first nanoglutathione complex for transdermal application in Brazil. Not bad not bad at all ☺️
It is not all about the ratio.
The copper/zinc ratio mainly reflects systemic inflammation.
Distribution and functional status is the additional issue. Blood tests can show enough copper (or even excess relative to zinc) while the copper is not properly reaching the enzymes that need it. Residual CF issues has been teaching me nuances up and close @drtaubraun
We need a randomized controlled trial that would include patients with intestinal inflammation (mild-moderate Crohn's disease or ulcerative colitis) and controls without intestinal inflammation.
Does creatine elevate brain creatine independently of, or mediated by, effects on the gut?
JAMA just put out a call for papers on “Women’s Health” for 2027. It mentions biological sex influencing disease and treatment, but frames everything as “women’s health.”
Why not a direct call on sex as a biological variable, looking at the real differences between men and women symmetrically? I mean, we are talking about science, yes?
My American mother mentioned how challenging it is to turn 90 next month. I hear her deeply. One thing is the letting go, the other is the acceptance of that letting go...
"Contrary to hypothesis, longer step lengths did not increase eccentric phase knee and hip extensor activities, but made the returning concentric phase movements more difficult. Thus, a normal step length appears sufficient for ELW [eccentric lunge walking]."
link.springer.com/article/10… (Wijethunga et al. 2026)
The company I work at has been using the word innovation in its marketing. I tried to push it back. We import patented compounds and replicate the latest international production techniques, but I don't think that means innovation… Thing is, while health professionals and consumers let it pass – and even praise how innovative the company is – I won't be heard. From this, what intrigues me the most is how a word that big can travel that far unnoticed.
A practical rule for anyone supplementing zinc chronically is to keep copper in the picture rather than to avoid zinc. Aim to ~10:1 ratio zinc to copper.
"Post Vaccination Syndrome is a cluster of persistent symptoms that can develop after vaccination, often resembling those seen in Long COVID or other post-viral syndromes. Symptoms may include fatigue, brain fog, nerve pain, dizziness, and rapid heart rate."
Register your injury. Your story matters:
react19.org/?utm_source=subs…
"Join Dr. Dale Bredesen and other experts at the Alzheimer’s World Summit, a free online event taking place October 7–11, 2026. This year’s theme, The Brain Longevity Blueprint, brings together perspectives on Alzheimer’s, cognitive health, and the decisions people face when looking for answers." alzheimersworldsummit.com/?u…
It is not yet a definitive efficacy trial. Thirty-one participants and 21 weeks of follow-up say that we still need to keep it in the proof-of-principle category.
Saying that, it is the strongest trial so far about the intermittent use of D + Q (3 cycles of 3 days/week for 3 weeks, each followed by 4 weeks off) on MASH, and results look good! ✨
"Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial" Koning et al. (2026)
nature.com/articles/s42255-0…
