Introducing AlphaProtein Novo, a pipeline for de novo enzyme design! In collaboration with @francesarnold's group, we developed AP Novo and used it to get SoTA "novel-scaffold" activity on 2 benchmark reactions and create enzymes to synthesize the pharmaceutical motif piperidine and degrade the environmental toxin DEHP.
Work led by @ZvxyWu @ZiqiLi0513 with teammates @alexechu_ @kelly_ruijie @schulluc @jacobjinkelly @rosaliags @davidla @solserpens @j_reisenbauer, @pengliu_group, Josh, Thomas, Amy, Tristan, Harshnira, and others. It was a joy and privilege to work with you all!
Preprints and code:
biorxiv.org/content/10.64898…
biorxiv.org/content/10.64898…
github.com/google-deepmind/a…
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMindJun 2
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
We believe AI can be a dedicated research partner to help discover the next breakthrough.
Enter Co-Scientist: our latest Gemini-based multi-agent system that can generate, debate and evolve novel hypotheses for complex scientific problems 🧵
Pushmeet Kohli retweeted
Our team at DeepMind is growing.
We've assembled a world class physics+material science team and are building an experimental lab.
If you want to solve real problems at the intersection of AI + material science to unlock a technological revolution - this is the place. Apply 👇
Pushmeet Kohli retweeted
Gemma 4 outperforms models over 10x their size! (note the x-axis is log scale!)
Pushmeet Kohli retweeted
We are thrilled to announce that Google’s Satellite Embedding dataset, powered by @GoogleDeepMind's AlphaEarth Foundations model, has been updated for 2025. This additional year of coverage now unlocks the ability to look back, compare, and detect change across the planet with unprecedented clarity. Learn more here ➡️ goo.gle/3NdIxWn
Part of Google's Earth AI, the new data represents the state of the planet throughout 2025, distilling petabytes of multi-sensor data into a 64-dimensional embedding for every 10 meter pixel.
What’s new in this update? 🧵👇
- 🌍 2025 Data: The state of the planet throughout 2025 is now available on the Earth Engine Data Catalog and Google Cloud Storage.
- 🔬 Unprecedented Change Detection: Because these embeddings capture subtle spectral, spatial and temporal signatures, they make it easy to spot significant year-over-year changes without the heavy lifting of raw image processing.
- 💚 Long-term Commitment: We are formalizing our commitment to the ongoing production of these annual layers to support your operational workflows.
Since we first launched the Satellite Embedding dataset, we’ve been inspired by how our community is putting this data to work. Applications are ranging from ecosystem mapping and agricultural crop-typing to carbon stock prediction. We can’t wait to see what you do next.
#EarthEngine #GeoAI #DeepMind
Pushmeet Kohli retweeted
Really happy to share our new paper on using AlphaEvolve for mathematical exploration at scale, written with Javier Gómez-Serrano, Terence Tao, and @GoogleDeepMind's Bogdan Georgiev. We tested it on 67 problems and documented all our successes and failures. 🧵
Pushmeet Kohli retweeted
Replying to @brendanbc2 @GoogleDeepMind
We are tackling grand challenges in semiconductors, magnets, energy materials, superconductors, and beyond.
If you want to push the boundaries of what's possible with first-principles simulation, join us in London. 🇬🇧
job-boards.greenhouse.io/dee…
job-boards.greenhouse.io/dee…
Pushmeet Kohli retweeted
At @GoogleDeepMind, our world-class team of quantum materials experts, engineers, and AI researchers is using massive-scale compute and AI to revolutionize materials discovery.
We're expanding! We are looking for truly exceptional computational materials scientists. 👇
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind30 Jul 2025
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
Our new AI model AlphaEarth Foundations is mapping the planet in astonishing detail. 🌏🔍
Scientists will now be able to track the impact of deforestation, monitoring crop health, and more – significantly faster, thanks to our new datasets. 🧵
Pushmeet Kohli retweeted
Pretty pleased with what I’ve seen inside this model (aka sequence rules learned), some of their predictions better recapitulate our CRISPR experiments in mouse than our own, smaller models. Excited to see the release!
Happy to introduce AlphaGenome, @GoogleDeepMind's new AI model for genomics.
AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.
Pushmeet Kohli retweeted

nature@Nature14 May 2025
United Kingdom!
United KingdomConnected via United Kingdom App StoreLocation may be affected by a proxy or VPN.Account-level information, not a live location or per-post device.
Google DeepMind has used chatbot models to come up with solutions to major problems in mathematics and computer science
go.nature.com/3ZkLEPd
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind8 May 2025
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
We’re celebrating a year of #AlphaFold 3 🧬✨
It’s been used to predict millions of molecular interactions – and scientists are using those predictions to accelerate research across crop immunity, bacterial resistance and more.
And at @IsomorphicLabs, they've been using it with their cutting-edge drug design engine with an ambition to change how new medicines are created. 💊
Find out more about AlphaFold 3 → deepmind.google/technologies…
Pushmeet Kohli retweeted
Excited to share details of AlphaGeometry2 (AG2), part of the system that achieved silver-medal standard at IMO 2024 last July! AG2 now has surpassed the average gold-medalist in solving Olympiad geometry problems, achieving a solving rate of 84% for all IMO geometry problems over the last 25 years, compared to 54% previously! Figure is a crazy problem solved elegantly by AG2 (for the first time according to our knowledge!). Will follow up with more details later in a thread.
Paper: arxiv.org/abs/2502.03544
Nature article: nature.com/articles/d41586-0…
Authors: Yuri Chervonyi, Trieu H. Trinh, Miroslav Olsak, Xiaomeng Yang, Hoang Nguyen, Marcelo Menegali, Junehyuk Jung, Vikas Verma, Quoc V. Le, Thang Luong
Special thanks to Dawsen Hwang, Edward Lockhart, and Steven Creech for contributions to the development of AlphaGeometry2. We would also like to thank Yifeng Lu, Henryk Michalewski, Ed Chi, David Silver, Pushmeet Kohli, and Demis Hassabis for their thoughtful discussions, help and support.
Super thrilled to share that our AI has has now reached silver medalist level in Math at #imo2024 (1 point away from 🥇)! Since Jan, we now not only have a much stronger version of #AlphaGeometry, but also an entirely new system called #AlphaProof, capable of solving many more Olympiad problems. This is a large-scale project that I was fortunate to co-lead at @GoogleDeepMind! See our blog & NYT articel below!
Blog: dpmd.ai/imo-silver
NYT: nytimes.com/2024/07/25/scien…
Pushmeet Kohli retweeted

Sundar Pichai@sundarpichai23 Oct 2024
United States
United StatesConnected via United States Android AppAccount-level information, not a live location or per-post device.
We've open sourced @GoogleDeepMind's SynthID, a tool that allows model creators to embed and detect watermarks in text outputs from their own LLMs. More details published in @Nature today: nature.com/articles/s41586-0…
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind11 Oct 2024
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
After the news was announced, John and Demis reunited with their teams in London.
A snapshot of what they had to say ↓
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind12 Jun 2024
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
Scientists from 120 countries have now used #AlphaFold Server to complete more than 620,000 jobs - to help test multiple hypotheses, predict complex interactions between proteins and DNA, and more. 🔬
Find out more in @Nature ↓
nature.com/nature/volumes/63…
Pushmeet Kohli retweeted
We have a long history of supporting responsible open source & science, which can drive rapid research progress, so we’re proud to release Gemma: a set of lightweight open models, best-in-class for their size, inspired by the same tech used for Gemini blog.google/technology/devel…
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind17 Jan 2024
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
Introducing AlphaGeometry: an AI system that solves Olympiad geometry problems at a level approaching a human gold-medalist. 📐
It was trained solely on synthetic data and marks a breakthrough for AI in mathematical reasoning. 🧵 dpmd.ai/alphageometry
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind14 Dec 2023
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
Introducing FunSearch in @Nature: a method using large language models to search for new solutions in mathematics & computer science. 🔍
It pairs the creativity of an LLM with an automated evaluator to guard against hallucinations and incorrect ideas. 🧵 dpmd.ai/x-funsearch
Pushmeet Kohli retweeted

Google DeepMind@GoogleDeepMind22 Nov 2023
United Kingdom
United KingdomConnected via WebAccount-level information, not a live location or per-post device.
SynthID can now watermark AI-created audio. 🎶
Its first deployment will be through Lyria, our most advanced AI music generation model to date.
How does it work? 🧵 dpmd.ai/synthid-audio
















