@psynautics

Advancing the science of mind and brain

 Los Angeles, CA
psynautics.com
Joined August 2020
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  • Following277
  • Followers472
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We collaborated with ALTERD and UCLA on this new preprint to address the etymology of the word “psychedelic” in relation to cannabis, meditation, and dreams. biorxiv.org/content/10.64898…

Mind-manifesting? Examining naturalistic reports from psychedelics, cannabis, meditation, and...

Altered states of consciousness (ASC) refer to states that differ markedly from normal waking consciousness. ASC may occur spontaneously, such as in dreaming, or through consciousness modifying...

biorxiv.org
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What mechanistic insights into nature are only accessible through internal observation?
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We are (slowly) building a platform to collect and match insights across independent observers to build an extended model of reality. DM if interested in joining our team.
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Breaking down our analysis of altered states of consciousness (ASC) and effort to empirically test “mind-manifesting” effects…🧵 akjournals.com/view/journals…
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Hallucination or observation? “Spinning furiously and gaining momentum down a gaudy plastic colored vortex right into some grotesquely ironic inner dimension at the core of matter, time, space and thought…”
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Amazing time hanging with @AcidForSquares to talk neuroscience of altered states... open.spotify.com/episode/1Fv…

#27 Dr. Conor Murray: The Neuroscience of Altered States

ACID FOR SQUARES · Episode

open.spotify.com
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Microdosing and heart health: 5-HT2B or not to be? “Together, these data provide no evidence of cardiovascular risk associated with prolonged administration of low-dose LSD in mice.” biorxiv.org/content/10.1101/…

Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice

Microdosing, the prolonged ingestion of psychedelics at sub-hallucinogenic doses, has gained popularity for its perceived cognitive and emotional benefits. Psychedelics have high affinity for 5-HT2B...

biorxiv.org
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Update: We now have an IRB-approved protocol to advance the neuroscience of microdosing vs. other mental health treatments in partnership with @InteraXon The work is funded by participants who receive a study kit with EEG headband and a data report at completion. Thanks all!
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Excited this paper from my postdoc at UChicago is out! “Microdoses” of LSD increase complexity, but not other drugs, even at doses that induce altered states (AS). AS was instead related to ⬇️ alpha. How might changes in entropy vs alpha predict outcomes? nature.com/articles/s41386-0…

Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC...

Neuropsychopharmacology - Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine

nature.com
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Metaphysics will become a science in the 21st century
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Happy birthday, Alan Watts
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The Creative Act (Rick Rubin)
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Planning to go to a meditation retreat this summer? Then please join our prospective survey studying the nature and impact of these experiences. Join here survey.alchemer.eu/s3/905248… @Imperial_PRG
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Researchers are getting better at using neuroimaging and AI to "read the mind's" language. Using similar approaches, we aim to reconstruct the ineffable. nature.com/articles/s41593-0…

Semantic reconstruction of continuous language from non-invasive brain recordings

Nature Neuroscience - Tang et al. show that continuous language can be decoded from functional MRI recordings to recover the meaning of perceived and imagined speech stimuli and silent videos and...

nature.com
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No cannabis for two weeks now. Superpowers beginning to activate. More likely than not that it will become a permanent abstinence. Downsides outweigh the upsides, particularly for those who are “well” and looking to further explore the outer reaches of human potential.
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Our group’s first paper will work to address this: On the need for metaphysics in psychedelic therapy and research frontiersin.org/articles/10.…

Frontiers | On the need for metaphysics in psychedelic therapy and research

The essential proposal of this text is that psychedelic-induced metaphysical experiences should be integrated and evaluated with recourse to metaphysics. It ...

frontiersin.org
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nytimes.com/interactive/2023…

A Psychedelics Pioneer Takes the Ultimate Trip (Published 2023)

“Life has been more beautiful, more wonderful than ever,” says Dr. Roland Griffiths, who has stage 4 cancer.

nytimes.com
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Two people in our microdosing study this week have shown significant reductions in experimental markers of Cognition (right broadband power), Emotion (left alpha power), and Awareness (Permutation Entropy) across their protocols. Meditation is a different story. @InteraXon
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The (undesirable) reductions were related to starting protocols at doses that were “too high” resulting in “unfocused” post-acute effects!
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Summing up the Vargas et al., 2023 Science paper with these tiles from Figs 1 and 3... note also that enhanced intracellular 5-HT2A activation by serotonin was sufficient to induce a head twitch response...
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