Fin Sparre inspected the Fabrikoid artificial-leather factory in Newburgh, New York, in 1910, after DuPont had already signed the purchase contract. He spent two days examining its processes and found inefficient, often dangerous operations. DuPont had committed itself before finding out how the factory worked.
Congressional pressure against the "Powder Trust" had pushed DuPont to find uses beyond powder for its nitrocellulose capacity. Nitrocellulose is cellulose, the polymer in plant fibers, chemically modified with nitrate ester groups. Fabrikoid consisted of a nitrocellulose coating on woven cloth. Irénée du Pont, head of DuPont's Development Department, saw an opening for a premium artificial leather that the company's chemical knowledge could help it make.
In September 1909, DuPont funded an experimental artificial-leather plant at its closing Oakland site. Within six months, chemists and engineers produced the premium grade Irénée wanted. Their key technique was solvent recovery, a process for collecting solvents for reuse. DuPont then assumed that the Fabrikoid Company's use of solvent recovery meant the artificial-leather maker's entire process was advanced. That assumption lay behind the purchase that brought Sparre to Newburgh.
After his inspection, DuPont spent two years repairing the factory and its market reputation. The material still stretched too much diagonally across its woven backing, and its coating wore away at folds and corners. Poor weather resistance threatened its use for automobile tops and upholstery. DuPont also tested shoe uppers, the material above the soles, on about 40 Wilmington mail carriers and sold 150 pairs locally. The shoes looked good and resisted water, but they lacked ventilation, softened, and cracked with repeated bending.
DuPont pursued four years of research to improve the material and try to match genuine leather. Researchers made definite improvements, while the company aimed Fabrikoid at automobile tops and upholstery. As the automobile industry grew in the 1910s, Fabrikoid's business grew with it.
DuPont put $43 million in 2026 dollars into the company purchase, and the business's return on investment rose from 0.5 percent in 1911 to 20 percent in 1919. It made money, with profits averaging about 15 percent over that period, because chemical knowledge and solvent recovery improved production, sustained research improved the product, and automobile growth expanded demand. But the material's remaining physical defects defeated the shoe application: DuPont never produced satisfactory artificial leather for boots and shoes.
Chemists usually handle catalysts carefully because the classic ones stop working on contact with air, so they work in sealed gloveboxes under argon. In 2000 Amir Hoveyda's lab at Boston College reported a ruthenium catalyst that chemists could store in a jar on a shelf and recover from a flask for reuse. His group combined its design with a catalyst from Robert Grubbs at Caltech to create the Hoveyda-Grubbs catalyst.
The catalyst enables olefin metathesis, a reaction that breaks carbon double bonds and swaps their halves to build new molecules. The method earned Grubbs a share of the 2005 Nobel Prize in Chemistry. Today the Hoveyda-Grubbs catalyst is among the most widely used in the field. For example, drug chemists use it to close the oversized molecular rings in drug candidates, and materials labs blend it into epoxy resins that repair their own cracks. US import records list it as a catalyst for making synthetic rubber.
Chemists invented the catalyst in Massachusetts and named it for two American professors, Hoveyda and Grubbs. The US imports about 11,000 pounds of it a year and reports no domestic production.
A yellow dye used to color polyester clothing sells for $147 per gram, 1.5 times the price of gold.
The chemical is a disperse dye. It embeds yellow color into polyester and other synthetic fibers that resist ordinary water-based dyes. Textile makers want purified dye because the shade has to stay consistent from batch to batch.
AK Scientific, Inc. in the US sells 1 gram for $147. A2B Chem LLC in the US sells 1 gram for $159.
This is one of 838 molecules selling today for more than gold per gram. Here's the list:
DuPont kept backing a machine to make black powder, an explosive mixture, at its Experimental Station during the financial panic of 1907. Executives believed that a safer, cheaper way to make it justified years of experiments.
The work began with Alfred du Pont, who in 1902 requested $110,000 in 2026 dollars for experiments in wet mixing. The black powder combined sulfur, a chemical element, charcoal, a carbon-rich solid, and sodium nitrate, a salt made of sodium and nitrate ions. Wet mixing meant combining those ingredients in a slurry, a mixture of solids and liquid, then drying it. Alfred wanted safer, faster production, but earlier inventors had struggled to keep sodium nitrate from crystallizing on the powder. DuPont expanded his idea into a continuous process, with connected operations intended to lower the cost of each unit of powder.
DuPont worked with machinery inventor J. N. Wingett, but development moved slowly from 1903 through 1907. By October of that last year, the Executive Committee had authorized $3.9 million for the project, excluding Wingett's salary. The panic brought instructions to finish the machinery for no more than another $110,000. Yet experiments continued: for the remainder of 1908 and throughout 1909, the committee funded the work at $74,000 per month, excluding the salaries of Wingett and Francis du Pont.
Material caked inside the machinery, and the powder itself had low density and performed poorly when fired. Under a microscope, researchers could still see crystals on the grain surfaces. Despite these problems, the process seemed developed enough for DuPont to begin patent work in mid-1909. Attorneys found almost all 200 of Wingett's claims worthless and unpatentable, so DuPont ended his contract.
The Station's full-time staff kept working through the first quarter of 1911. Further work nearly eliminated the mechanical faults, but the powder remained unsatisfactory. DuPont narrowed the effort to wet mixing followed by its established batch operations, which handled separate quantities of powder: pressing it, forming grains, smoothing their surfaces by glazing, and drying them.
In January 1912, DuPont ordered the continuous-process machinery scrapped, abandoning a venture that had consumed about $6.9 million in development spending, excluding salaries. The venture lost money because the technical defects left it without a commercial advantage; the limited wet-mix approach offered no savings either, and the Station ended that work too. DuPont had hired Wingett before developing the idea in house, Francis du Pont had managed him poorly, and the Station had taken too long to judge the process.
A whole cucumber has little scent, but within seconds of cutting it, enzymes meet substances that intact cells had kept apart from them and make fresh aroma molecules on the cut surface. One of these molecules is trans-2,cis-6-nonadien-1-ol, a nine-carbon alcohol that perfumers buy as violet leaf alcohol because violet leaves have the same cool, watery-green scent.
The alcohol is so potent that suppliers sell it diluted to 1 percent, a strength used to add cucumber scent to melon flavors and a damp green scent to violet and lily of the valley perfumes. Making violet leaf absolute, the natural extract with this scent, takes about 1,800 kilos of hand-picked leaves from Egyptian fields to yield a single kilo of extract. The synthetic alcohol provides the same watery-green scent in a bottle. The US imports its entire supply of the alcohol and reports no domestic production.
The plant hormone used to size up seedless grapes sells for $453 per gram, 5 times the price of gold.
Gibberellic acid tells plants to grow. A small dose can wake seeds, lengthen stems, and make grape berries bigger, which gives growers control over size and timing.
Labotest KG in Germany sells 1000 milligrams for $453. Princeton BioMolecular Research (SC) in the United States sells 100 milligrams for $290.
This is one of 838 molecules selling today for more than gold per gram. Here's the list:
Divers' watches used to glow with radioactive paint; dial painters used radium into the 1960s and tritium after that. Nemoto, a Japanese company, had supplied watchmakers with luminous paint since 1941. In 1993 four of its researchers heated strontium and aluminum with a boron melting aid and two rare earth elements, europium and dysprosium, to make a new pigment.
A spoonful of the powder could absorb an afternoon's daylight and glow in a dark room until morning, up to ten times brighter than the old zinc sulfide paints. Nemoto patented it in 1994 and sold it as LumiNova. By 1998 Swiss watchmakers had stopped using radioactive paint.
The powder is aluminum strontium borate oxide with small amounts of europium and dysprosium added. It now makes watch hands and exit signs glow, along with stairwell markings that stay visible when a building loses power. The US imports about 42,000 pounds of it a year and reports no production of its own.
A chemical used in numbing injections for medical procedures sells for $1,110 per gram, 12 times the price of gold.
Chloroprocaine hydrochloride is a local anesthetic. It briefly blocks nerve signals near the injection site, so doctors can numb a procedure area without putting the patient fully under. That matters because short procedures need pain control that wears off fast.
A2B Chem LLC in the US sells 100 milligrams for $111. TargetMol Chemicals EU in Austria sells 50 milligrams for $95.
This is one of 838 molecules selling today for more than gold per gram. Here's the list:
Trying to do some obscurant related research for DOD with Opus/Astra. They refuse. So guess what? I have to use a chinese model GLM 5.3. What's the point of this? What's the benefit to ths USA?
Prospectors cursed pyrite as fool's gold because it glittered in the pan but had no value. But in Nevada's big gold deposits, pyrite contains real gold as stray atoms and specks too small for any microscope to see. A prospector could stand over a valuable deposit without knowing the gold was inside the pyrite crystals.
Extracting the gold starts with potassium pentylxanthate, a pale yellow powder miners call PAX. It is the strongest collector in the xanthate family, used to attach mineral grains to bubbles. Mill workers grind the ore to dust and stir it into water before adding PAX. PAX coats the pyrite grains so they catch rising bubbles and reach the top of the tank as a heavy gray froth carrying gold too small to see. In the 1990s Santa Fe Pacific Gold used this process at industrial scale at its Lone Tree mine in Nevada, using nitrogen instead of air for the bubbles because tarnished pyrite stays submerged in ordinary air.
Mines around the world also use PAX to concentrate nickel and copper sulfides, minerals containing sulfur. The US imports about 284,000 pounds of it a year and produces none.
A chemical used to make flame-retardant plastics sells for $151.20 per gram, 1.6 times the price of gold.
Manufacturers use it as a monomer, a small molecule that becomes part of plastic. Once built in, it helps the finished material resist ignition, which matters anywhere plastic sits near heat or electronics.
Angene Chemical in Hong Kong sells it for $756 for 5 grams. Aaron Chemicals LLC in Hong Kong sells it for $758 for 5 grams.
This is one of 838 molecules selling today for more than gold per gram. Here's the list:
