The environmental pressures on a modern gut are undoubtedly different from those of our hunter-gatherer ancestors. The microbiomes would reflect this. What does this mean for us today? The paleo vs plant-based debate shows this is complex. More data would help!

We now have clear guidance from JCVI on those patients eligible for a 3rd primary dose of COVID vaccine. This includes IBD patients on infliximab, adalimumab, ustekinumab, tofacitinib, prednisolone and some on high-dose aza/mp/mtx. Details here & below gov.uk/government/publicatio…

The impact of Crohn's disease and UC on a person's life can be devastating. With 1 in 125 of the population living with #IBD it is important we realise what they might be going through. It isn't just physical; here 👇 are just some of the ways IBD affects people.

We are developing and testing increasingly targeted therapies for Crohn's disease & ulcerative colitis. New molecules will hopefully bring increased efficacy with minimal / no safety issues. Not all will make it to market - some have already failed. But there is more to come.

Prevention and cure are big words with a big impact. But are they possible in IBD? I've mapped out some of the key steps to move us to preventing IBD. Data are coming ... #ship30for30

Day 13 of #ship30for30 paging all @predicct participants and requesting you complete the final follow-up questionnaire please xitter.cf/charlie_lees/status/14…

What happens when the delicate balance between environment, genes and microbiota is disrupted? Inflammatory bowel disease (IBD) can develop Crohn's disease and ulcerative colitis now affect 1 in 125 people in the developed world. The numbers are going up fast elsewhere.

I have a big favour to ask. Have you taken part in the @PREdiCCt study? Then we need your help. Please log into the PREdiCCt portal and complete the final questionniare. Here is why this is so important and a big thank you. @crohnscolitisUK @crohnscolitisc3

Multiple environmental factors impact the gut in health and inflammatory bowel disease: • diet • sleep • travel • stress • surgery • hygiene • exercise • smoking • geography • emulsifiers • medications Important to take a HOLISTIC approach to health and disease.

These data were presented as an e-poster at the DDW and ECCO meetings this year by our IBD clinical fellow turned consultant @SSiakavellas Here is the full poster [👇] @predicct @UoE_CGEM @LauranneDerikx

What causes disease flares in IBD? We asked the 2639 participants of the @PREdiCCt study in their baseline questionnaire. 1946 replied - these were their top responses • stress (69.8%) • dietary changes (46.8%) • alcohol (19%) • sleep disturbance (17%) #ship30for30

I've started to think about life for our patients post-pandemic. We face many challenges but I'm optimistic. Advances in drug development, genomics, digital health, AI & more. This is the start of a new series on Innovations in IBD & the story of the innovators. #ship30for30

We asked 1946 patients with Crohn's and UC in remission about fatigue: here's what we found. 40% of patients were fatigued >50% of the time. Factors associated with fatigue • depression & anxiety • clinical disease activity • female sex and higher BMI @PREdiCCt #Ship30for30