
ALT This figure shows a hypothetical clinical interface in which AI generates diagnostic and management recommendations while the physician evaluates their appropriateness, incorporates patient priorities, and judges when to defer or intervene. Displayed findings and confidence estimates are illustrative.

ALT The image is a series of panels showing antitumor activity, pharmacokinetics, and phenotypic evolution of interleukin-15 and interleukin-21 coexpressing glypican-3–specific chimeric antigen receptor (CAR) T cells. Panel A shows pre- and postinfusion axial CT images of the chest at indicated time points; the red arrows indicate the tumor. Panel B shows alpha-fetoprotein levels in peripheral blood, as measured in the clinical laboratory. Panel C shows the results from samples that were collected at indicated time points to determine the expansion and persistence of the engineered populations of the 15.21.GPC3-CAR T cells. Panels D and E show changes in the T-cell subsets expressing CAR and iC9.15.21 before and after the infusion, as determined by flow cytometry.































