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What's never been done: whole-genome or whole-exome tumor/normal sequencing, whole-transcriptome RNA-seq, germline testing, and IHC for drug targets like CLDN18.2, TROP2, CDH17, Nectin-4, and BRG1. His tissue blocks are available.
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His tumor is microsatellite stable with a low mutational burden, and two DNA panels found no targetable driver. Standard immunotherapy isn't an option. He starts FOLFOX at Duke this week.
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My dad, Rickie Lee Kyle, is 69 and has stage 4 small bowel adenocarcinoma that grew out of decades of Crohn's disease. It's rare, and patients like him are left out of most colorectal cancer trials. As his son and a physician, I'm asking for help. 🧵
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The CEO of Solana single handedly changed the vote last minute
Build this man a statue
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Until recently, Hamideh Soleimani Afshar and her daughter were green card holders living lavishly in the United States.
Afshar is the niece of deceased Iranian Major General Qasem Soleimani. She is also an outspoken supporter of the Iranian regime who celebrated attacks on Americans and referred to our country as the "Great Satan."
This week, I terminated both Afshar and her daughter's legal status and they are now in ICE custody, pending removal from the United States.
The Trump Administration will not allow our country to become a home for foreign nationals who support anti-American terrorist regimes.
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Reuters and Axios are now also reporting that Iranian Supreme Leader Ayatollah Ali Khamenei has been eliminated by an Israeli strike this morning on Tehran.
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BRING HIM BACK
NEW from @WSJ:
@GlennYoungkin shines, delivering Virginia surpluses, economic wins, and an over 50% approval rating in a deep blue state.
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JUST IN: 5 days into the new year, and gas prices are already falling across the U.S.
- Below $3.00/gal in 40 states
- Below $2.75/gal in 26 states
- Below $2.50/gallon in 17 states
- Below $2.00/gallon in 10 states
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Wait, didn’t you & Biden put a $25m bounty on Maduro right before leaving office? (1/10/2025)
Didn’t you try to look strong after deaths from overdose hit record breaking numbers on your watch?
The only difference is he got the job done.
You couldn’t even protect the border.
Donald Trump’s actions in Venezuela do not make America safer, stronger, or more affordable.
That Maduro is a brutal, illegitimate dictator does not change the fact that this action was both unlawful and unwise. We’ve seen this movie before. Wars for regime change or oil that are sold as strength but turn into chaos, and American families pay the price.
The American people do not want this, and they are tired of being lied to.
This is not about drugs or democracy. It is about oil and Donald Trump’s desire to play the regional strongman. If he cared about either, he wouldn’t pardon a convicted drug trafficker or sideline Venezuela’s legitimate opposition while pursuing deals with Maduro’s cronies.
The President is putting troops at risk, spending billions, destabilizing a region, and offering no legal authority, no exit plan, and no benefit at home.
America needs leadership whose priorities are lowering costs for working families, enforcing the rule of law, strengthening alliances, and — most importantly — putting the American people first.
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THE NEXT CHAPTER
As many of you know, Daniel and I have been running the Futurum Equities podcast for six months now covering the 4th Industrial Revolution across names like:
• AI Security | $CRWD, $ZS, $PANW, $RBRK
• Grid & Power | $CEG, $NEE, $VST, $EOSE, $NNE
• AI Data Platforms | $PLTR, $SNOW, $MDB, $NOW
• Nuclear | $OKLO, $SMR, $LEU, $GEV, $CCJ, $BWXT
• AI Cloud | $MSFT, $AMZN, $GOOGL, $DOCN, $ORCL
• AI Utility | $CRWV, $NBIS, $IREN, $CIFR, $WULF, $APLD
• AI Networking | $AVGO, $ALAB, $MRVL, $CRDO, $NET, $ANET
• AI Chips | $NVDA, $TSM, $ASML, $AMAT, $KLAC, $AMD, $MU, $LRCX, $ARM
The momentum has been incredible to see now that our X livestreams is averaging 24K viewers per episode but we’ve decided it’s time for a bigger stage.
We’re officially moving the show to YouTube.
If you want to keep watching our Friday market-open live streams, make sure to subscribe below 👇
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A Final Goodbye : The Last KFC Radio ever out now.
Link : youtu.be/QpORuXbyZYI?si=M2t5…
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The average monthly price of groceries for a family of four in the US is now $1,030…
+30% just since Covid.
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$RIVN to $100.


































