We investigate diverse aspects of #immunometabolism, #immunology, #macrophages, #ferroptosis and #aminoacids
Martinsried, Germany
Joined December 2021
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Peter J Murray retweeted
A great study by the Hoffmann lab in @JExpMed shows innate immune memory can be propagated in a cell-extrinsic way via local cytokine trapping. In our Insight, Luca Frosio and I discuss how these findings suggest spatial niche-specific contron of trained immunity 🎯
Insights: Frosio and Ostuni @MyUniSR discuss study by Gorin et al. (hubs.la/Q043CjJY0) which reveals an unexpected mechanism by which IFN-γ sustains trained immune states through prolonged signaling driven by cytokine retention at the cell surface. hubs.la/Q043CjzR0
Peter J Murray retweeted
We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @ImmunityCP @DIB_UNIL
sciencedirect.com/science/ar…
Peter J Murray retweeted
Abstract Submission, Travel Award Applications, and Early Fee Deadline Extended to February 28. Join us at the 21st International Conference on #Innate #Immunity
in #Sissi #Crete #Greece May 22-27, 2026 #InnateImmunity aegeanconferences.org/src/Ap…
65 years ago, the stability liver enzyme that controls tryptophan metabolism (TDO2) then called tryptophan pyrrloase, was shown to be regulated by substrate amounts (using “ancient” but clever biochemistry esp. by the late and legendary Bob Schimke).
TDO2 stability is controlled by CK2-FBXW11 that recognizes phosphodegrons exposed when tryptophan is limiting. Tryptophan blocks this process, ensuring a balance between substrate and the enzyme that degrades it. 65 years later, well done Alina and team!
Peter J Murray retweeted
REMINDER: Submit your abstract, trainee award application, and online registration to the 21st Int'l Conference on #InnateImmunity held in #Sissi, #Crete, #Greece from May 22-27, 2026 aegeanconferences.org/src/Ap… #innate #immunity #Neuroimmunology #immunometabolism #Pathophysiology
ALT The specific topics include: Evolution of the innate immune system, Host-microbe interactions, Interactions with adaptive immunity, Neuroimmunology, immunometabolism, trained immunity, Pathophysiology-Inflammation, Structural biology, and Therapeutic applications. Abstracts are invited from the international community for all these topics.
Many people played key roles in the iDeg-IDO1-KLHDC3 story from Brenda Schulman's lab, @TengTengXu1 from my group, brilliant work from the chemists and especially Natalie Scholes and Danny Scott (@StJudeResearch)
Out today: the results of a multi-lab collaboration led by Herbert Waldmann and Georg Winter that shows the iDeg class of IDO1 inhibitors developed by Waldmann's lab have a dual function: they inhibit IDO1 but also promote Ub-mediated degradation.
Peter J Murray retweeted
Out today 🙌 new work from the lab in which we show that p53-driven senescence enables phospholipid headgroup recycling to help sustain the increased synthesis of membrane phospholipids of senescent cells nature.com/articles/s41556-0…
Today is Three Kings Day (Epiphany) in southern Germany and outside my lab at 11 am it was -18°C. Even on our pond at @MPI_Biochem (normally guarded by a badger and some ornery geese, it was possible to skate
To add to the excellent debate initiated by @LocasaleLab, I was cleaning up seminar slides and found a few gems from my "Mentoring" talk I give every now and again. Starting with 2009...
