@PhysRep

An online only, open access journal publishing peer-reviewed research across all areas of physiology. A collaboration between The PhySoc and the APS.

physiologicalreports.org
Joined March 2013
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Replying to @PhysRep
@physrep.bsky.social @APSPhysiology @physoc @physoc.bsky.social @WileyBiomedical @WileyNeuro
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@PhysRep: #Acetazolamide, an inhibitor of carbonic anhydrase that can induce arteriolar #vasodilation, is shown in this pilot study of acute #braininjury patients to increase brain #oxygenation and #intracranial #pressure. doi.org/10.14814/phy2.70159 @Hypoxia @CerebralVasculature

Effects of acetazolamide on intracranial pressure and brain tissue oxygenation on patients with...

Administration of acetazolamide in patients with acute brain injury resulted in a significant increase in brain oxygenation, accompanied by a concurrent rise in ICP and flow velocities, suggesting...

physoc.onlinelibrary.wiley.com
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@PhysRep: Hearts of #pyruvatekinase M2 KO mice show increased oxidative stress, #inflammation and #fibrosis after #myocardial #infarction, implicating a protective role of #PKM2. doi.org/10.14814/phy2.70193 @Cardiovascular

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart

Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM). We previously identified...

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@PhysRep: In this new paper, #thoracic load carriage in hypoxic conditions to mimic high #altitude is shown to increase physiological strain and interfere with compensatory responses to #hypoxia in healthy males. doi.org/10.14814/phy2.70197 @Respiratory #MuscleFatigue #Hemodynamics

Thoracic load carriage impairs the acute physiological response to hypoxia in healthy males

To assess the impact of thoracic load carriage on the physiological response to exercise in hypoxia. Healthy males (n = 12) completed 3 trials consisting of 45 min walking in the following conditio...

physoc.onlinelibrary.wiley.com
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@PhysRep: This new report shows that regulation of miRNA-1, a #skeletal #muscle specific #miR, is necessary for mechanical overload-induced muscle #hypertrophy in a mouse model doi.org/10.14814/phy2.70166 #myotwitter

miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice

Schematic representation of mice subjected to mechanical overload (via synergist ablation) following miR-1 overexpression to determine its role in skeletal muscle hypertrophy. Muscle tissue samples...

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@PhysRep: Congratulations to all the Authors of our most-read papers of 2024! @physoc @APSPhysiology @WileyBiomedical #Physiology
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@PhysRep: This comparison of #arterial #stiffness at different body sites in swimmers, cyclists and untrained controls indicates swimmers can develop segment-specific reduction in #heart #brachial arterial stiffness. doi.org/10.14814/phy2.70186 @Exercise @Vascular

Investigations of segmental arterial stiffness in a cross‐sectional study on young adult male...

Contrary to cardiovascular risk reductions by aerobic exercise, arterial stiffness, as assessed by brachial-ankle pulse wave velocity (PWV), is higher in swimmers and controls than in other aerobic...

physoc.onlinelibrary.wiley.com
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@PhysRep: Inter-organ #metabolism in @sepsis: this study in a porcine model of acute sepsis investigates the across-organ net fluxes of #gluconeogenesis substrates and the roles of #adipose and #muscle tissue breakdown doi.org/10.14814/phy2.70129

The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudo...

Sepsis leads to an acute breakdown of muscle to support increased caloric and amino acid requirements. Little is known about the role of adipose and muscle tissue breakdown and intestinal metabolism...

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@PhysRep: This study on mice deleted for regulator of #Gprotein signaling proteins reports LV dilation and increased #myocardial #immune cells, without additional effect of sustained #βadrenergic receptor signaling doi.org/10.14814/phy2.70178 @Cardiovascular @Heart #CellSignalling

Germline deletion of Rgs2 and/or Rgs5 in male mice does not exacerbate left ventricular remodeling...

Regulation of Gαi/o by RGS2 and RGS5 of the R4 family of RGS proteins is key to homeostatic control of cardiac structure and function by adenylyl cyclase (AC)-mediated cAMP signaling downstream of...

physoc.onlinelibrary.wiley.com
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@PhysRep: New report on #cardiac, autonomic, #haemodynamic and #biomarker responses in trained men taking 2 Olympic distance, lab. based #duathlon, 7 days apart. Functional and biomarker changes were similar to after #triathlon. doi.org/10.14814/phy2.70154 @Cardiovascular @Exercise
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@PhysRep: Studies on female hormonal responses to #exercise are limited. This report shows that a 30-min exercise #stress test leads to hormonal elevations in saliva and plasma of young healthy females. doi.org/10.14814/phy2.70168 #WomensHealth @Physiology @Endocrinology

Plasma and salivary hormone responses to a 30‐min exercise stress test in young, healthy, physica...

Overreaching, a consequence of intensified training, is used by athletes to enhance performance. A blunted hormonal response to a 30-min interval exercise stress test (55/80) has been shown in males...

physoc.onlinelibrary.wiley.com
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@PhysRep: Studies on female hormonal responses to #exercise are limited. This report shows that a 30-min exercise #stress test leads to hormonal elevations in saliva and plasma of young healthy females. doi.org/10.14814/phy2.70168 #WomensHealth @Physiology @Endocrinology

Plasma and salivary hormone responses to a 30‐min exercise stress test in young, healthy, physica...

Overreaching, a consequence of intensified training, is used by athletes to enhance performance. A blunted hormonal response to a 30-min interval exercise stress test (55/80) has been shown in males...

physoc.onlinelibrary.wiley.com
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@PhysRep: This study sets up a new methodology to induce #Cardiac #alternans like contraction status in vitro in human-induced pluripotent #stemcell derived #cardiomyocytes doi.org/10.14814/phy2.70152 @Cardiovascular @iPSC @CellPhysiology

Induction of cardiac alternans in human iPS‐derived cardiomyocytes through β‐adrenergic receptor...

Cardiac alternans (C-ALT) is a phenomenon of alternating strong and weak contractions in the heart and is considered a risk factor for the development of heart failure and arrhythmias. However, no...

physoc.onlinelibrary.wiley.com
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@PhysRep: The editors thank all authors, reviewers, editors, readers and journal staff for their support of Physiological Reports in 2024. Wishing All in our community Happy Holidays and great research in 2025! @APSPhysiology @physoc @WileyBiomedical @WileyNeuro #Physiology
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@PhysRep: Our Editor’s choice paper from November is "Force monitoring reveals single trial dynamics of motor control in a stop signal task" by Surabhi Ramawat and colleagues. Read the paper at: doi.org/10.14814/phy2.70127 #Biomechanics

Force monitoring reveals single trial dynamics of motor control in a stop signal task

The Stop Signal Task (SST) has been the benchmark for studying the behavioral and physiological basis of movement generation and inhibition. In our study, we extended the scope beyond physiological...

physoc.onlinelibrary.wiley.com
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@PhysRep: Also now posting on BlueSky! @physrep.bsky.social @physoc.bsky.social @ThePhysSoc @APSPhysiology @WileyBiomedical
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@PhysRep: This study examines how #hypercholanemia disturbs #pregnancy-related @adipose tissue expansion and mRNA expression in late gestation in mice, with implications for #intrahepatic #cholestasis of @pregnancy doi.org/10.14814/phy2.70141

Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a...

Women with intrahepatic cholestasis of pregnancy (ICP) have hypercholanemia alongside an increased risk of dyslipidemia. We investigated how cholic acid (CA) supplementation in murine pregnancy...

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@PhysRep: This study in a porcine model compares unilateral and bilateral @RenalArtery #stenosis conditions to investigate effects on #Renal pressure-flow relationship and #renin activation doi.org/10.14814/phy2.70082

Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and...

Because renal artery stenosis (RAS) often presents bilateral, we sought to investigate the renal pressure-flow relationship and its relation to renin release, in the presence of a contralateral...

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@physrep: New study comparing #physiological responses of healthy adults to computer-based cognitive or #motor-cognitive training shows motor-cognitive SKILLCOURT to be adaptable for a broad range of #exercise intensities. doi.org/10.14814/phy2.70136 #Heartrate @Respiratory
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@PhysRep: Our Call for Papers on Women’s Health Research in Basic and Translational @Physiology is now open! Find out more at physoc.onlinelibrary.wiley.c… @APSPhysiology @physoc @physoc.bsky.social @WileyBiomedical
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@PhysRep: Study of effects of Fetal #growth #restriction on gene expression during #differentiation of perirenal #preadipocytes implicates target genes that may affect the risk of male FGR for obesity in adulthood. doi.org/10.14814/phy2.70143 #epigenetics @developmentalbiology

Intrauterine fetal growth restriction in sheep leads to sexually dimorphic programming of Preadip...

Fetal growth restriction (FGR) is a risk factor for obesity in adult life. Importantly, growth-restricted females are more prone to obesity than males. The mechanisms involved in this sexually...

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