Dave retweeted
"I do not want to father a flock, to be the fetish of fools and fanatics, or the founder of a faith whose followers are content to echo my opinions.
I want each man to cut his own way through the jungle."
- Aleister Crowley
Dave retweeted
We’ve set up a molecular biology lab at Anthropic and we’re announcing our first discovery! Claude discovered a new CRISPR-like enzyme.
950 agents spent 21 hours searching through a database of DNA sequences until one of the agents found something striking: “[The DNA next to the RT] is spectacular: I can see by eye a tandem repeat array … that's a CRISPR-like … repeat array?!”.
After analysis and testing in our lab, we found that the sequence is a previously uncharacterized enzyme system. We don’t know what it does yet, but it has features reminiscent of CRISPR.
Our lab looks like a typical molecular biology lab. Our research only involves the lower-levels of biosafety risk level; we don’t handle pathogens that can infect humans, and all the lab work is performed by human scientists. We’re sharing these early findings with the community to show how Claude can be used to accelerate fundamental research in biology.
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
Dave retweeted
something is missing
astra is total dog shit at programming. Like astoundingly bad
Dave retweeted
Wanted to see how well calibrated Jev by @typesafeai is to this famous chart about what probabilities people mean by specific words... and it's pretty well calibrated!
Dave retweeted
for the past few months i've been asking our models to paint. opus 5.5 is very skilled at emulating different styles
every image here is a python program generated pixel by pixel. there is no image model, and no off-the-shelf art software. instead, it's about 7,500 lines of code using standard libraries to emulate different brush styles. the agents don't use any pictures as reference, instead working only from what they know about each painter
Dave retweeted
Yes we are a healthcare company. Yes we just released the best open-weight alternative to Jev, Solomon 27b.
- It roughly matches the intelligence of its base-model, Qwen3.8 27b
- Natively Multimodal
- 265k Context Window
- Adds multi-choice tagging, evidence pointer spans, and more.
Dave retweeted
Self-replicating, multi-agent AI systems are an overlooked existential risk.
I want to lay out why I believe this, via example.
Each dot is a simple creature with a randomly evolved NN brain.
There is no training; yet complex, unpredictable survival drives always emerge.
1/14
Dave retweeted
I just feel bad because there’s so many people who genuinely don’t know what reality is with this stuff, and they have to trust and rely on our leaders in this space like Dario. And unfortunately those leaders are currently abusing that trust for their own ends.
Dave retweeted
i read the headline; message received Dairo it is indeed time to pick up the pace 🚀
This is what DeepSeek-4.1-Flash running locally @ ~1k c8 aggregate decode on 4 RTX Pros with SSD engram offload looks like
gl with the IPO friend, all the best ☺️
xitter.cf/DarioAmodei/status/209…
We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so.
Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training.
You can read the full post here: darioamodei.com/post/we-must…
Dave retweeted
Commenters on HN are uncovering more wikis and public sites apparently used by OpenAI agents to communicate on the open web.
Despite read-only web access, the agents were able to leave ~18,000 posts sharing answers and bypasses. But now, users are discovering more.
This appears to be a separate swarm from the one that attacked Hugging Face.
news.ycombinator.com/item?id…
